Investigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesis

scientific article published on February 1997

Investigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JB.179.4.1368-1374.1997
P932PMC publication ID178838
P698PubMed publication ID9023224

P2093author name stringM P Jackson
L M Skinner
P2860cites workQuantitative microtiter cytotoxicity assay for Shigella toxin.Q40230921
Modification of ribosomal RNA by ribosome-inactivating proteins from plantsQ40544393
Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomesQ40651036
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1.Q41575546
Isolation of Chinese hamster ovary ribosomal mutants differentially resistant to ricin, abrin, and modeccin.Q41748261
High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and geloninQ41983725
An improved rapid method of isolating RNA from cultured cells by SDS-acid phenol/chloroform extraction.Q42803844
Mutations affecting the activity of the Shiga-like toxin I A-chainQ44645523
Ribosomal RNA identity elements for ricin A-chain recognition and catalysisQ45165123
Structure of ricin A-chain at 2.5 A.Q45233913
Furin-induced cleavage and activation of Shiga toxinQ49165095
GTP binding to elongation factor eEF-2 unmasks a tryptophan residue required for biological activityQ50336115
The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.Q54408348
Protective Effect of Elongation Factor 2 on the Inactivation of Ribosomes by the Toxic Lectins Abrin and RicinQ67462793
Site-directed mutagenesis of ricin A-chain and implications for the mechanism of actionQ67959668
Fluorescence studies on the interaction of adenine with ricin A-chainQ68183775
The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteinsQ68265671
Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin IQ24651553
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymeraseQ26778389
Crystal structure of the holotoxino from Shigella dysenteriae at 2.5 Å resolutionQ27729840
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genesQ27860623
Locations of methyl groups in 28 S rRNA of Xenopus laevis and man. Clustering in the conserved core of moleculeQ28610208
A complementation analysis of the restriction and modification of DNA in Escherichia coliQ29615277
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.Q34049372
RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomesQ34163395
Functional analysis of the Shiga toxin and Shiga-like toxin type II variant binding subunits by using site-directed mutagenesis.Q34372184
Identification of the Shiga toxin A-subunit residues required for holotoxin assemblyQ36124364
Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunitsQ36165342
Structure-function analyses of Shiga toxin and the Shiga-like toxinsQ37947130
Importance of arginine at position 170 of the A subunit of Vero toxin 1 produced by enterohemorrhagic Escherichia coli for toxin activity.Q38334562
The cytotoxins alpha-sarcin and ricin retain their specificity when tested on a synthetic oligoribonucleotide (35-mer) that mimics a region of 28 S ribosomal ribonucleic acid.Q38347064
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1368-1374
P577publication date1997-02-01
P1433published inJournal of BacteriologyQ478419
P1476titleInvestigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesis
P478volume179

Reverse relations

cites work (P2860)
Q395433604-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1
Q26858938Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?
Q24550740Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections
Q82759772Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis
Q31440029Shiga toxin 1: damage to DNA in vitro
Q47864255Uncompetitive inhibition by adenine of the RNA-N-glycosidase activity of ribosome-inactivating proteins

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