Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?

scientific article

Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/TOXINS7051467
P932PMC publication ID4448158
P698PubMed publication ID25938272
P5875ResearchGate publication ID275953053

P2093author name stringDebaleena Basu
Nilgun Tumer
P2860cites workShiga toxin receptor Gb3Cer/CD77: tumor-association and promising therapeutic target in pancreas and colon cancerQ21090050
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Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages fromEscherichia coli933Q57563895
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Interaction of elongation factor eEF-2 with ribosomal P proteinsQ77773230
The C-terminal end of P proteins mediates ribosome inactivation by trichosanthin but does not affect the pokeweed antiviral protein activityQ80725838
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Yeast ribosomal P0 protein has two separate binding sites for P1/P2 proteinsQ83013729
Pokeweed antiviral protein accesses ribosomes by binding to L3.Q54107189
Solution structure of human P1*P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosomeQ27679227
The Crystal Structure of Shiga Toxin Type 2 with Bound Disaccharide Guides the Design of a Heterobifunctional Toxin InhibitorQ27680604
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Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2BQ28207582
Differential tissue targeting and pathogenesis of verotoxins 1 and 2 in the mouse animal modelQ33343579
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Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coliQ33388849
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Overview and Historical PerspectivesQ33419782
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Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humansQ33505189
Biophysical properties of the eukaryotic ribosomal stalkQ33522691
Comparison of the relative toxicities of Shiga-like toxins type I and type II for miceQ33605233
Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a modelQ33753680
Comparison of binding platforms yields insights into receptor binding differences between shiga toxins 1 and 2Q33801217
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.Q34049372
Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteinsQ34166278
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.Q34172482
Human intestinal tissue and cultured colonic cells contain globotriaosylceramide synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide.Q34290908
Shiga toxinsQ34298388
Pentameric organization of the ribosomal stalk accelerates recruitment of ricin a chain to the ribosome for depurinationQ34438778
Nucleotide sequence of the Shiga-like toxin genes of Escherichia coliQ34633814
Structure and Dynamics of Ribosomal Protein L12: An Ensemble Model Based on SAXS and NMR RelaxationQ40625926
Role of verotoxin receptors in pathogenesisQ41052833
The large ribosomal subunit stalk as a regulatory element of the eukaryotic translational machinery.Q41096585
Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activationQ41627064
Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analysesQ41934174
A mode of assembly of P0, P1, and P2 proteins at the GTPase-associated center in animal ribosome: in vitro analyses with P0 truncation mutantsQ42039672
The catalytic subunit of shiga-like toxin 1 interacts with ribosomal stalk proteins and is inhibited by their conserved C-terminal domainQ42648942
Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptorQ42920438
Three binding sites for stalk protein dimers are generally present in ribosomes from archaeal organismQ43023215
Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activationQ43116255
Kinetic analysis of binding between Shiga toxin and receptor glycolipid Gb3Cer by surface plasmon resonanceQ43738152
Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalkQ44572057
Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.Q44838252
RIBOSOME-INACTIVATING PROTEINS: A Plant PerspectiveQ44875240
The primary structure of rat ribosomal proteins P0, P1, and P2 and a proposal for a uniform nomenclature for mammalian and yeast ribosomal proteinsQ48220438
Promiscuous Shiga toxin 2e and its intimate relationship to Forssman.Q48691738
Furin-induced cleavage and activation of Shiga toxinQ49165095
Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiaeQ34663367
Shiga toxin subtypes display dramatic differences in potencyQ34739913
Revising the taxonomic distribution, origin and evolution of ribosome inactivating protein genesQ34988582
Acute renal tubular necrosis and death of mice orally infected with Escherichia coli strains that produce Shiga-like toxin type IIQ35109009
Comparisons of native Shiga toxins (Stxs) type 1 and 2 with chimeric toxins indicate that the source of the binding subunit dictates degree of toxicityQ35132357
The puzzling lateral flexible stalk of the ribosomeQ35179486
Glycolipid binding preferences of Shiga toxin variantsQ35199053
Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2Q35501790
Investigation of ribosome binding by the Shiga toxin A1 subunit, using competition and site-directed mutagenesisQ35620166
Antiviral activity of ribosome inactivating proteins in medicineQ35794009
Ribosome-inactivating proteinsQ35859613
Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesisQ35946837
Delivery into cells: lessons learned from plant and bacterial toxinsQ36091291
Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunitsQ36165342
Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclatureQ36172302
Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1.Q36194407
The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cellsQ36296036
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.Q36459565
Targeting ricin to the ribosomeQ36901746
Comparison of the glycolipid receptor specificities of Shiga-like toxin type II and Shiga-like toxin type II variantsQ36977977
In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activityQ37006892
The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiaeQ37088333
A two-step binding model proposed for the electrostatic interactions of ricin a chain with ribosomes.Q37180842
Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalkQ37234010
Monoclonal antibody 11E10, which neutralizes shiga toxin type 2 (Stx2), recognizes three regions on the Stx2 A subunit, blocks the enzymatic action of the toxin in vitro, and alters the overall cellular distribution of the toxin.Q37256478
Shiga toxins--from cell biology to biomedical applicationsQ37659792
RNA toxins: mediators of stress adaptation and pathogen defenseQ37910091
Facing glycosphingolipid-Shiga toxin interaction: dire straits for endothelial cells of the human vasculatureQ38024274
Ribosome-inactivating proteins: from toxins to useful proteinsQ38086669
Ribosome-inactivating proteins: potent poisons and molecular toolsQ38144759
Free energy determinants of binding the rRNA substrate and small ligands to ricin A-chainQ38329838
Importance of arginine at position 170 of the A subunit of Vero toxin 1 produced by enterohemorrhagic Escherichia coli for toxin activity.Q38334562
Detecting ricin: sensitive luminescent assay for ricin A-chain ribosome depurination kineticsQ38355109
Structures of eukaryotic ribosomal stalk proteins and its complex with trichosanthin, and their implications in recruiting ribosome-inactivating proteins to the ribosomesQ38365820
Tumor-specific targeting of pancreatic cancer with Shiga toxin B-subunitQ39501025
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectenzymeQ8047
protein subunitQ899781
bacterial proteinQ64923821
P304page(s)1467-85
P577publication date2015-04-29
P1433published inToxinsQ15724569
P1476titleDo the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?
P478volume7

Reverse relations

cites work (P2860)
Q43196106Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells
Q61697249Enterohemorrhagic (Shiga Toxin-Producing) Escherichia coli
Q42695863Enterotoxins: Microbial Proteins and Host Cell Dysregulation
Q40774571Identification of Shiga toxin-producing (STEC) and enteropathogenic (EPEC) Escherichia coli in diarrhoeic calves and comparative genomics of O5 bovine and human STEC.
Q42251450In silico analysis of Shiga toxins (Stxs) to identify new potential vaccine targets for Shiga toxin-producing Escherichia coli.
Q33426867The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.

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