Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle

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Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1047359179
P356DOI10.1186/S13567-015-0175-2
P8608Fatcat IDrelease_ks6liqgaizftrgljnord7kqdlm
P932PMC publication ID4391668
P698PubMed publication ID25889651
P5875ResearchGate publication ID274732720

P50authorStefanie BarthQ41292171
P2093author name stringChristian Menge
Katharina Kerner
Hermann Willems
Georg Baljer
Julia Fröhlich
Rolf Bauerfeind
Gabriele Köpf
Philip S Bridger
P2860cites workEvidence that glutamic acid 167 is an active-site residue of Shiga-like toxin IQ24651553
Effect of Shiga toxin and Shiga-like toxins on eukaryotic cellsQ33337469
Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptomsQ33340303
Infection by Shiga toxin-producing Escherichia coli: an overviewQ33358878
Phenotypic and functional characterization of intraepithelial lymphocytes in a bovine ligated intestinal loop model of enterohaemorrhagic Escherichia coli infectionQ33360834
Neutralizing activity of bovine colostral antibody against verotoxin derived from enterohemorrhagic Escherichia coli O157:H7 in miceQ33373297
Protection against Shiga toxin 1 challenge by immunization of mice with purified mutant Shiga toxin 1.Q35012362
Bovine immune response to shiga-toxigenic Escherichia coli O157:H7Q35216120
Serum antibody responses of cattle following experimental infection with Escherichia coli O157:H7Q35493730
Enterohaemorrhagic Escherichia coli: emerging issues on virulence and modes of transmissionQ36104071
Enterohaemorrhagic E. coli in veterinary medicine.Q36291977
Epithelial and mesenchymal cells in the bovine colonic mucosa differ in their responsiveness to Escherichia coli Shiga toxin 1Q36949959
An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swineQ36957798
An investigation of the expression and adhesin function of H7 flagella in the interaction of Escherichia coli O157 : H7 with bovine intestinal epithelium.Q53438323
Non-toxic Stx derivatives from Escherichia coli possess adjuvant activity for mucosal immunity.Q54265531
Escherichia coli Nissle 1917 for probiotic use in piglets: evidence for intestinal colonization.Q54404636
Isotype-specific antibody responses against Escherichia coli O157:H7 locus of enterocyte effacement proteins in adult beef cattle following experimental infection.Q54438442
Vaccination of calves with EspA, a key colonisation factor of Escherichia coli O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation.Q54444786
Escherichia coli Shiga toxin 1 enhances il-4 transcripts in bovine ileal intraepithelial lymphocytes.Q54458662
Decreased shedding of Escherichia coli O157:H7 by cattle following vaccination with type III secreted proteins.Q54514056
A long-term study on the prevalence of shiga toxin-producing Escherichia coli (STEC) on four German cattle farms.Q54538848
Generation and functional characterization of bovine bone marrow-derived macrophagesQ72756559
Detection of colostrum-derived alloantibodies in calves with bovine neonatal pancytopeniaQ83312501
Maternally and naturally acquired antibodies to Shiga toxins in a cohort of calves shedding Shiga-toxigenic Escherichia coliQ37204311
Bovine colostral antibody against verotoxin 2 derived from Escherichia coli O157:H7: resistance to proteases and effects in beagle dogs.Q37243829
A systematic review of vaccinations to reduce the shedding of Escherichia coli O157 in the faeces of domestic ruminantsQ37913560
Bovine innate and adaptive immune responses against Escherichia coli O157:H7 and vaccination strategies to reduce faecal shedding in ruminantsQ38053703
Importance of arginine at position 170 of the A subunit of Vero toxin 1 produced by enterohemorrhagic Escherichia coli for toxin activity.Q38334562
Escherichia coli O157:H7 colonization in cattle following systemic and mucosal immunization with purified H7 flagellin.Q39023163
Shiga toxin 1 from Escherichia coli blocks activation and proliferation of bovine lymphocyte subpopulations in vitro.Q39610465
Quantitative microtiter cytotoxicity assay for Shigella toxin.Q40230921
Regulation of proinflammatory cytokine expression by Shiga toxin 1 and/or lipopolysaccharides in the human monocytic cell line THP-1Q40564019
Bovine ileal intraepithelial lymphocytes represent target cells for Shiga toxin 1 from Escherichia coliQ40705289
Shiga toxin 1-induced activation of c-Jun NH(2)-terminal kinase and p38 in the human monocytic cell line THP-1: possible involvement in the production of TNF-alpha.Q40758329
Globotriaosylceramide (Gb(3)/CD77) is synthesized and surface expressed by bovine lymphocytes upon activation in vitro.Q40774338
Globotriaosyl ceramide modulates interferon-alpha-induced growth inhibition and CD19 expression in Burkitt's lymphoma cellsQ40835280
Detection and characterization of diarrheagenic Escherichia coli from young children in Hanoi, VietnamQ41041264
Subunit vaccines based on intimin and Efa-1 polypeptides induce humoral immunity in cattle but do not protect against intestinal colonisation by enterohaemorrhagic Escherichia coli O157:H7 or O26:H-.Q42084913
The mode of action of Shiga toxin on peptide elongation of eukaryotic protein synthesisQ42856082
Genetically modified Shiga toxin 2e (Stx2e) producing Escherichia coli is a vaccine candidate for porcine edema diseaseQ43654014
Immunization of pigs with a purified Shiga-like toxin II variant toxoidQ43813100
Bovine lymphocytes express functional receptors for Escherichia coli Shiga toxin 1.Q44258652
Verotoxin 1 from Escherichia coli affects Gb3/CD77+ bovine lymphocytes independent of interleukin-2, tumor necrosis factor-alpha, and interferon-alphaQ44387597
Analysis of the phenotype and phagocytic activity of monocytes/macrophages from cattle infected with the bovine leukaemia virusQ45755281
Neutralizing antibodies against Shiga-like toxins from Escherichia coli in colostra and sera of cattle.Q49232754
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectEscherichia coliQ25419
P304page(s)38
P577publication date2015-04-10
P1433published inVeterinary ResearchQ15761008
P1476titleEvaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle
P478volume46

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cites work (P2860)
Q52668818Decreased STEC shedding by cattle following passive and active vaccination based on recombinant Escherichia coli Shiga toxoids.
Q40730550Effect of lactoferrin on release and bioactivity of Shiga toxins from different Escherichia coli O157:H7 strains.
Q61717619Efficacy of a recombinant Intimin, EspB and Shiga toxin 2B vaccine in calves experimentally challenged with Escherichia coli O157:H7
Q36238457Immune Response in Calves Vaccinated with Type Three Secretion System Antigens and Shiga Toxin 2B Subunit of Escherichia coli O157:H7

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