Disruption of an internal membrane-spanning region in Shiga toxin 1 reduces cytotoxicity

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Disruption of an internal membrane-spanning region in Shiga toxin 1 reduces cytotoxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.66.11.5252-5259.1998
P932PMC publication ID108656
P698PubMed publication ID9784530

P2093author name stringC J Hovde
M L Suhan
P2860cites workEvidence that glutamic acid 167 is an active-site residue of Shiga-like toxin IQ24651553
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Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
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Molecular cloning and nucleotide sequence of another variant of the Escherichia coli Shiga-like toxin II familyQ34050888
Vero response to a cytotoxin of Escherichia coliQ34177128
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Nucleotide sequence of the Shiga-like toxin genes of Escherichia coliQ34633814
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Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swineQ36215407
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Shigella dysenteriae 1 cytotoxin: periplasmic protein releasable by polymyxin B and osmotic shock.Q36342126
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Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicityQ37664951
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Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperatureQ39948895
Endocytosis and intracellular sorting of ricin and Shiga toxinQ40764137
Role of verotoxin receptors in pathogenesisQ41052833
On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.Q41094039
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1.Q41575546
Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coliQ42657348
Furin-induced cleavage and activation of Shiga toxinQ49165095
Insertion and orientation of a synthetic peptide representing the C-terminus of the A1 domain of Shiga toxin into phospholipid membranes.Q50537524
Interaction of Shigella toxin with globotriaosyl ceramide receptor-containing membranes: a fluorescence study.Q50888903
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Efficient production of heat-labile enterotoxin mutant proteins by overexpression of dsbA in a degP-deficient Escherichia coli strain.Q54567334
Purification of recombinant Shiga-like toxin type I A1 fragment from Escherichia coli.Q54632708
The role of tyrosine-114 in the enzymatic activity of the Shiga-like toxin I A-chain.Q54648744
Proteolytic cleavage at arginine residues within the hydrophilic disulphide loop of the Escherichia coli Shiga-like toxin I A subunit is not essential for cytotoxicity.Q54650779
Construction and expression of diphtheria toxin-encoding gene derivatives in Escherichia coli.Q54676822
Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulumQ59097697
A hydrophobic region of ricin A chain which may have a role in membrane translocation can function as an efficient noncleaved signal peptideQ70800465
Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin moleculeQ70875563
Purification of recombinant shiga-like toxin type I B subunitQ71363666
Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocationQ71735154
Role of processing and intracellular transport for optimal toxicity of Shiga toxin and toxin mutantsQ72210047
Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cellsQ73248328
Orientation in lipid bilayers of a synthetic peptide representing the C-terminus of the A1 domain of shiga toxin. A polarized ATR-FTIR studyQ73940499
Toxin entry: how reversible is the secretory pathway?Q75292684
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)5252-5259
P577publication date1998-11-01
P1433published inInfection and ImmunityQ6029193
P1476titleDisruption of an internal membrane-spanning region in Shiga toxin 1 reduces cytotoxicity
P478volume66

Reverse relations

cites work (P2860)
Q44402969A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation.
Q34007607Antiviral activity of shiga toxin 1: suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation
Q34531637Antiviral activity of shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells
Q34663367Identification of amino acids critical for the cytotoxicity of Shiga toxin 1 and 2 in Saccharomyces cerevisiae
Q73285682Intracellular trafficking and membrane translocation of pertussis toxin into host cells
Q28476692Modulation of toxin stability by 4-phenylbutyric acid and negatively charged phospholipids
Q39625812Polyclonal antibodies to glutathione S-transferase--verotoxin subunit a fusion proteins neutralize verotoxins
Q42065084Shiga toxin is transported from the endoplasmic reticulum following interaction with the luminal chaperone HEDJ/ERdj3.
Q34407346The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect
Q34492828The cholera toxin A1(3) subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosol
Q54400239Towards an attenuated enterohemorrhagic Escherichia coli O157:H7 vaccine characterized by a deleted ler gene and containing apathogenic Shiga toxins.
Q34426721Toxin instability and its role in toxin translocation from the endoplasmic reticulum to the cytosol

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