R. John Collier

American microbiologist and biochemist

DBpedia resource is: http://dbpedia.org/resource/R._John_Collier

Abstract is: R. John Collier (born August 6, 1938) is an American microbiologist and biochemist. He is the Maude and Lillian Presley Professor of Microbiology and Immunobiology, Emeritus at Harvard Medical School.

Born 1938-08-06 in Wichita Falls (Q128349)

R. John Collier is …
instance of (P31):
humanQ5

External links are
P2381Academic Tree ID17943
P11496CiNii Research ID1140000791878369792
P6178Dimensions author ID0637515620.19
P968email addressjcollier@hms.harvard.edu
P646Freebase ID/m/0gm5wtd
P6594Guggenheim fellows IDr-john-collier
P269IdRef ID112210309
P213ISNI0000000037265636
P3874Justia Patents inventor IDr-john-collier
P244Library of Congress authority IDn85263153
P6366Microsoft Academic ID2276864183
P271NACSIS-CAT author IDDA06364779
P5380National Academy of Sciences member ID59399
P1006Nationale Thesaurus voor Auteursnamen ID299001202
P856official websitehttp://micro.med.harvard.edu/faculty/collier.html
P496ORCID iD0000-0002-2427-4239
P1153Scopus author ID7202591916
P4012Semantic Scholar author ID2166180
P214VIAF ID6381890
P10832WorldCat Entities IDE39PBJbM9MCxvCmH4rT888wXBP

P512academic degreeDoctor of PhilosophyQ752297
P1416affiliationHarvard Medical SchoolQ49121
P166award receivedPaul Ehrlich and Ludwig Darmstaedter PrizeQ458338
Guggenheim FellowshipQ1316544
Selman A. Waksman Award in MicrobiologyQ2268592
Fellow of the American Association for the Advancement of ScienceQ5442484
Bristol-Myers Squibb Award for Distinguished Achievement in Infectious Diseases ResearchQ30123947
Fellow of the American Academy of Arts and SciencesQ52382875
P27country of citizenshipUnited States of AmericaQ30
P69educated atHarvard UniversityQ13371
University of GenevaQ503473
Rice UniversityQ842909
P108employerHarvard UniversityQ13371
Harvard Medical SchoolQ49121
University of California, Los AngelesQ174710
UCLA Division of Life SciencesQ105427200
P734family nameCollierQ16865687
CollierQ16865687
CollierQ16865687
P101field of worktoxinQ184651
anthrax toxinQ1935986
P735given nameRobertQ4927937
RobertQ4927937
JohnQ4925477
JohnQ4925477
P1412languages spoken, written or signedEnglishQ1860
P463member ofNational Academy of SciencesQ270794
American Academy of Arts and SciencesQ463303
P1559name in native languageR. John Collier
P106occupationbiologistQ864503
biochemistQ2919046
microbiologistQ3779582
P39position heldprofessor emeritusQ1240569
P21sex or gendermaleQ6581097
P937work locationBostonQ100

Reverse relations

author (P50)
Q347126232001: a year of major advances in anthrax toxin research
Q35978682A dually active anthrax vaccine that confers protection against both bacilli and toxins
Q42575392A hybrid toxin containing fragment A from diphtheria toxin linked to the B protomer of cholera toxin
Q34684419A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation
Q34721109A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1
Q42932650A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore
Q28610278A quantitative study of the interactions of Bacillus anthracis edema factor and lethal factor with activated protective antigen
Q40056223A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor
Q46090423A soluble receptor decoy protects rats against anthrax lethal toxin challenge
Q30160407Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin
Q57214158Active-Site Mutations of Diphtheria Toxin: Role of Tyrosine-65 in NAD Binding and ADP-Ribosylation
Q43761887Active-site mutations of diphtheria toxin: effects of replacing glutamic acid-148 with aspartic acid, glutamine, or serine
Q54633625Active-site mutations of the diphtheria toxin catalytic domain: role of histidine-21 in nicotinamide adenine dinucleotide binding and ADP-ribosylation of elongation factor 2.
Q46476517Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin
Q44186485Amino acid sequence homology between the enzymic domains of diphtheria toxin and Pseudomonas aeruginosa exotoxin A.
Q42060301An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen
Q57213891Anthrax Toxin
Q44534485Anthrax delivers a lethal blow to host immunity
Q30481474Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature
Q36987540Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells
Q47594951Anthrax protective antigen: efficiency of translocation is independent of the number of ligands bound to the prepore
Q30175382Anthrax protective antigen: prepore-to-pore conversion
Q33764677Anthrax toxin as a molecular tool for stimulation of cytotoxic T lymphocytes: disulfide-linked epitopes, multiple injections, and role of CD4(+) cells
Q34341387Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously
Q34001191Anthrax toxin entry into polarized epithelial cells
Q30830672Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation
Q28572283Anthrax toxin receptor 2-dependent lethal toxin killing in vivo
Q33750314Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin
Q37242580Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo
Q33846416Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers
Q36750138Anthrax toxin: receptor binding, internalization, pore formation, and translocation
Q34714854Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host
Q36401049Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells
Q36579365Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus
Q41737111Assembly and disassembly kinetics of anthrax toxin complexes
Q39365433Assembly of anthrax toxin pore: lethal-factor complexes into lipid nanodiscs
Q41453913Association of polyomavirus middle tumor antigen with 14-3-3 proteins
Q54188364Binding of transfer factor II to ribosomal RNA and inhibition of the binding by guanosine nucleotides.
Q24320977Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen
Q37374866Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells
Q40990167Characterization of membrane translocation by anthrax protective antigen
Q42733846Chemical dissection of protein translocation through the anthrax toxin pore
Q38352596Circular dichroism of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and various derivatives
Q33788263Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines
Q41684401Conformation of the diphtheria toxin T domain in membranes: a site-directed spin-labeling study of the TH8 helix and TL5 loop
Q57214204Conformational integrity of a recombinant toxoid of Pseudomonas aeruginosa exotoxin A containing a deletion of glutamic acid-553
Q42113997Conformational switching of the diphtheria toxin T domain
Q46264263Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo
Q41947351Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin
Q27636113Crystal structure of the anthrax lethal factor
Q27734828Crystal structure of the anthrax toxin protective antigen
Q24564886Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
Q27729754Crystal structure of the zeta isoform of the 14-3-3 protein
Q57214323Crystallization of exotoxin A from Pseudomonas aeruginosa
Q30175359Crystallographic studies of the anthrax lethal toxin
Q42722552Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore
Q39612918Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity
Q41529992DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis
Q30727461Designing a polyvalent inhibitor of anthrax toxin
Q34439762Differences in the immunogenicity of native and formalinized cross reacting material (CRM197) of diphtheria toxin in mice and guinea pigs and their implications on the development and control of diphtheria vaccine based on CRMs.
Q27930295Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.
Q46396048Diphtheria toxin: quantification and assay
Q33580226Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function
Q57213936Dominant-Negative Mutants of a Toxin Subunit: An Approach to Therapy of Anthrax
Q46877309Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation
Q57214133Effect of Anthrax Toxin's Lethal Factor on Ion Channels Formed by the Protective Antigen
Q57214018Effects of Mutations in Proline 345 on Insertion of Diphtheria Toxin into Model Membranes
Q51822438Effects of dynamin inactivation on pathways of anthrax toxin uptake.
Q33707063Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen
Q37124252Evidence for a proton-protein symport mechanism in the anthrax toxin channel
Q24651553Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I
Q37695526Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel
Q44247948Exchange characteristics of calcium ions bound to anthrax protective antigen
Q37020985Expression of a mutant, full-length form of diphtheria toxin in Escherichia coli.
Q37019195Expression of the S-1 catalytic subunit of pertussis toxin in Escherichia coli.
Q44560499Fluorescence resonance energy transfer studies on anthrax lethal toxin
Q30157196Functions of phenylalanine residues within the beta-barrel stem of the anthrax toxin pore
Q37405396Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen
Q30370145GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore.
Q36802132Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death
Q30176262Identification of residues lining the anthrax protective antigen channel
Q28204415Identification of the cellular receptor for anthrax toxin
Q50554709Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras.
Q28189050Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein
Q57213769Insertion of Anthrax Protective Antigen into Liposomal Membranes
Q57214029Interaction of Diphtheria Toxin T Domain with Molten Globule-Like Proteins and Its Implications for Translocation
Q45227405Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics
Q24329122Interaction of the protein kinase Raf-1 with 14-3-3 proteins
Q46033478Interaction of transferase II with the 60 s ribosomal subunit.
Q34550250Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling
Q33995847Involvement of domain 3 in oligomerization by the protective antigen moiety of anthrax toxin
Q34088991Locating a residue in the diphtheria toxin channel
Q33713102Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis
Q43803655Mapping the anthrax protective antigen binding site on the lethal and edema factors
Q34068323Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen
Q57214076Membrane Topography of the T Domain of Diphtheria Toxin Probed with Single Tryptophan Mutants†
Q57214040Membrane Translocation of Charged Residues at the Tips of Hydrophobic Helices in the T Domain of Diphtheria Toxin†
Q30160208Membrane insertion by anthrax protective antigen in cultured cells
Q40267216Membrane translocation and channel-forming activities of diphtheria toxin are blocked by replacing isoleucine 364 with lysine
Q37535082Membrane translocation by anthrax toxin
Q30153524Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance
Q46945188Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth
Q41662769Mutational analysis of the helical hairpin region of diphtheria toxin transmembrane domain
Q36268438NAD binding site of diphtheria toxin: identification of a residue within the nicotinamide subsite by photochemical modification with NAD
Q36639252On the role of macrophages in anthrax
Q46067618Organization of diphtheria toxin T domain in bilayers: a site-directed spin labeling study
Q30167650PA63 channel of anthrax toxin: an extended beta-barrel
Q54623818Participation of lysine 516 and phenylalanine 530 of diphtheria toxin in receptor recognition.
Q36670023Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation
Q57214052Photoaffinity Labeling of Diphtheria Toxin Fragment A with 8-Azidoadenosyl Nicotinamide Adenine Dinucleotide†
Q40687644Photoaffinity labeling of active site residues in ADP-ribosylating toxins
Q37536131Photoaffinity labeling of diphtheria toxin fragment A with NAD: structure of the photoproduct at position 148.
Q37006249Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD.
Q30168578Point mutations in anthrax protective antigen that block translocation
Q34502790Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore
Q57213970Preclinical evaluation of group B streptococcal polysaccharide conjugate vaccines prepared with a modified diphtheria toxin and a recombinant duck hepatitis B core antigen
Q36435877Probing the structure of the diphtheria toxin channel. Reactivity in planar lipid bilayer membranes of cysteine-substituted mutant channels with methanethiosulfonate derivatives
Q57214142Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus
Q57213803Protein Translocation through the Anthrax Toxin Transmembrane Pore is Driven by a Proton Gradient
Q34188068Protein translocation through anthrax toxin channels formed in planar lipid bilayers
Q54021249Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization.
Q35423582Reaction of diphtheria toxin channels with sulfhydryl-specific reagents: observation of chemical reactions at the single molecule level.
Q39110294Receptor-directed chimeric toxins created by sortase-mediated protein fusion
Q24532114Receptor-specific requirements for anthrax toxin delivery into cells
Q27636598Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity
Q35556378Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain
Q44925110Reversible refolding of the diphtheria toxin T-domain on lipid membranes
Q33613555Reversion of recombinant toxoids: mutations in diphtheria toxin that partially compensate for active-site deletions
Q34544082Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen
Q38298647Role of glutamic acid 988 of human poly-ADP-ribose polymerase in polymer formation. Evidence for active site similarities to the ADP-ribosylating toxins
Q36437476Role of macrophage oxidative burst in the action of anthrax lethal toxin.
Q42060384Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin
Q30157192Solubilization and characterization of the anthrax toxin pore in detergent micelles
Q31034679Stoichiometry of anthrax toxin complexes
Q57213811Structural Determinants for the Binding of Anthrax Lethal Factor to Oligomeric Protective Antigen
Q30449676Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution
Q24301840Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation
Q27730334Structure of the isolated catalytic domain of diphtheria toxin
Q57084785Structure-function relationships in diphtheria toxin channels: I. Determining a minimal channel-forming domain
Q39216259Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen
Q28250331The crystal structure of diphtheria toxin
Q36436081The diphtheria toxin channel-forming T domain translocates its own NH2-terminal region across planar bilayers
Q34068311The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen
Q40089051The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin
Q27642935The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
Q40563937Three dimensional structure of the anthrax toxin translocon-lethal factor complex by cryo-electron microscopy
Q33734525Three-dimensional structure of the anthrax toxin pore inserted into lipid nanodiscs and lipid vesicles
Q36444940Topography of diphtheria Toxin's T domain in the open channel state
Q35550977Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T domain
Q35289314Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers
Q34398330Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century
Q46720421Whole-cell voltage clamp measurements of anthrax toxin pore current
Q33613504pH-dependent insertion of proteins into membranes: B-chain mutation of diphtheria toxin that inhibits membrane translocation, Glu-349----Lys
Q36380649pH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes.
Q57821408pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen

winner (P1346)
Q30123947Bristol-Myers Squibb Award for Distinguished Achievement in Infectious Diseases Research
Q458338Paul Ehrlich and Ludwig Darmstaedter Prize

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