Gastrointestinal stromal tumors: a paradigm for molecularly targeted therapy

scientific article published on January 2003

Gastrointestinal stromal tumors: a paradigm for molecularly targeted therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1081/CNV-120022374
P698PubMed publication ID14533446

P50authorMargaret von MehrenQ66809438
P2860cites workSTK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cellsQ24305016
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Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumorQ33941495
Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database.Q34155715
Gastrointestinal stromal tumors and leiomyosarcoma of the abdomen and retroperitoneum: a clinical comparison.Q34250686
Gastrointestinal stromal tumors: their origin and causeQ34437402
Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrenceQ34503968
Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival.Q34506729
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptorQ34567286
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Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 casesQ35745870
Mutations in exon 11 of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomasQ35754637
Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factorQ37552904
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implicationsQ40783216
A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumorsQ40997984
Requirement for mast cell growth factor for primordial germ cell survival in cultureQ41668856
The kit ligand: A cell surface molecule altered in steel mutant fibroblastsQ41718670
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Smooth muscle cells, interstitial cells of Cajal and myenteric plexus interrelationships in the human colon.Q43912430
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A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene familyQ48366626
Immunophenotype, proliferation, DNA ploidy, and biological behavior of gastrointestinal stromal tumors: a multivariate clinicopathologic study.Q50869688
Surgical management of gastrointestinal stromal tumors of the stomachQ57649267
Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and stagingQ67731122
Solitary solid stromal gastrointestinal tumors in von Recklinghausen's disease with minimal smooth muscle differentiationQ70466502
Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomasQ73461799
Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit geneQ73513320
PRIMARY SOLID TUMORS OF THE MESENTERYQ76500193
Interstitial cells of Cajal as precursors of gastrointestinal stromal tumorsQ77311208
Coincidence of Crohn's disease and a high-risk gastrointestinal stromal tumor of the terminal ileumQ77961693
Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 casesQ78229382
P433issue4
P304page(s)553-563
P577publication date2003-01-01
P1433published inCancer InvestigationQ325953
P1476titleGastrointestinal stromal tumors: a paradigm for molecularly targeted therapy
P478volume21

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cites work (P2860)
Q36318541Individualised cancer therapeutics: dream or reality?
Q36293536Molecular research directions in the management of gastrointestinal stromal tumors
Q36472432Technology insight: pharmacoproteomics for cancer--promises of patient-tailored medicine using protein microarrays

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