Alternate interferon signaling pathways

scientific article published on October 1, 2003

Alternate interferon signaling pathways is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0163-7258(03)00070-6
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0163725803000706?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0163725803000706?httpAccept=text/plain
P698PubMed publication ID14550502

P2093author name stringDhananjaya V. Kalvakolanu
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Inhibition of the interferon-inducible protein kinase PKR by HCV E2 proteinQ22010192
Cooperation among Stat1, glucocorticoid receptor, and PU.1 in transcriptional activation of the high-affinity Fc gamma receptor I in monocytesQ22254125
Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursorsQ22254187
Functional role of type I and type II interferons in antiviral defenseQ24276429
Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinaseQ24290751
Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activationQ24290901
A transcriptional corepressor of Stat1 with an essential LXXLL signature motifQ24290918
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cellsQ24291206
The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitroQ24291320
The locus-specific enhancer activity of the class I major histocompatibility complex interferon-responsive element is associated with a gamma-interferon (IFN)-inducible factor distinct from STAT1alpha, p48, and IFN regulatory factor-1.Q41150401
ISGF3 gamma p48, a specificity switch for interferon activated transcription factorsQ41157748
Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cellsQ41224915
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartiteQ41260447
Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP.Q41267086
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2.Q41293458
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathwayQ41361506
Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic antigen (CEA) and HLA expression by human colorectal carcinoma cells: role for endogenous IFN-betaQ41374783
GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.Q41404184
Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene inductionQ41434003
Activation of the protein tyrosine kinase tyk2 by interferon alpha/betaQ41454373
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.Q41457392
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.Q41460849
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathwayQ41514580
NF-IL6 and NF-kappa B in cytokine gene regulationQ41545806
Antiproliferative potencies of interferons on melanoma cell lines and xenografts: higher efficacy of interferon betaQ41609229
Interferon regulatory factor-1 is inducible by prolactin, interleukin-2 and concanavalin A in T cellsQ41617442
Signal transduction through MAP kinase cascadesQ41750250
Terminal differentiation of myeloleukemic M1 cells induced by IL-6: role of endogenous interferonQ42083756
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.Q42123661
Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytesQ42513731
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signalingQ42673076
Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane SignalingQ42679205
The carboxyl terminus of interferon-gamma contains a functional polybasic nuclear localization sequenceQ42823288
KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathwayQ42834462
The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivoQ42943882
Interferon-beta is required for interferon-alpha production in mouse fibroblastsQ43412872
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domainQ43498366
Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signallingQ43688291
Interferon alpha2b increases paracellular permeability of renal proximal tubular LLC-PK1 cells via a mitogen activated protein kinase signaling pathwayQ43703540
Involvement of the IRF-1 transcription factor in antiviral responses to interferonsQ44518832
Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early proteinQ45734610
Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta geneQ45784282
The growing family of interferon regulatory factorsQ47992425
Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acidQ48051237
A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cellsQ48084253
LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator proteinQ48255574
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.Q50335883
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domainQ28506778
An essential role for C/EBPbeta in female reproductionQ28507381
Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 inductionQ28513103
IRF family of transcription factors as regulators of host defenseQ28513569
Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alphaQ28513836
Constitutive nuclear localization of Janus kinases 1 and 2Q28565323
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBPQ28575310
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinaseQ28581201
Structure and function of a new STAT-induced STAT inhibitorQ28584775
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivoQ28588059
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivoQ28609049
Molecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transductionQ28609565
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8Q28609808
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6Q28609813
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzymeQ28610362
Requirement of serine phosphorylation for formation of STAT-promoter complexesQ28637366
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding proteinQ28646262
The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factorsQ28646350
Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven processQ28646352
Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 bindingQ28646364
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinaseQ28646398
Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3Q28646506
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 proteinQ28646517
Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinaseQ28646526
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arraysQ28646554
STATs and gene regulationQ29547796
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral diseaseQ29615967
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathwayQ29615968
Identification of a novel inhibitor of mitogen-activated protein kinase kinaseQ29616448
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosomeQ29616850
Cellular responses to interferon-gammaQ29618567
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionQ29620054
Viruses and interferonsQ29620788
The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1.Q30167565
Activation of a CrkL-stat5 signaling complex by type I interferons.Q30175923
A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)Q30195316
Interferon-kappa, a novel type I interferon expressed in human keratinocytesQ24291586
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survivalQ24291845
Activities of IRF-1Q24292304
IRF-1 as a negative regulator of cell proliferationQ24292306
Molecular cloning and expression of the human interferon-gamma receptorQ24294544
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with MycQ24294647
Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genesQ24295016
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteinsQ24296810
Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNAQ24300964
Identification of a nuclear Stat1 protein tyrosine phosphataseQ24302061
Inhibition of Stat1-mediated gene activation by PIAS1Q24310082
A family of cytokine-inducible inhibitors of signallingQ24313168
A new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP geneQ24313328
The human interferon alpha/beta receptor: characterization and molecular cloningQ24313421
Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNAQ24318311
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transductionQ24319109
A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptorQ24319127
PACT, a protein activator of the interferon-induced protein kinase, PKR.Q24319677
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 proteinQ24323485
Identification and sequence of an accessory factor required for activation of the human interferon gamma receptorQ24336191
The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32Q24336213
NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokinesQ24336834
Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signalingQ24337125
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activityQ24531180
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42Q24532640
Identification of novel stress-induced genes downstream of chopQ24533261
Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7Q24533409
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 proteinQ24536345
A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoproteinQ24537405
CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivationQ24551176
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transductionQ24564242
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainQ24604330
A single DNA response element can confer inducibility by both alpha- and gamma-interferonsQ24626821
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory regionQ24628753
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genesQ24643507
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylationQ24644334
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complexQ24647642
Two contact regions between Stat1 and CBP/p300 in interferon gamma signalingQ24658040
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTPQ24679086
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase betaQ24681806
Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding proteinQ24683287
Cell signaling by receptor tyrosine kinasesQ27860474
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
How cells respond to interferonsQ27861006
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1Q28114883
A protein tyrosine kinase in the interferon alpha/beta signaling pathwayQ28116574
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactionsQ28118180
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2Q28118615
PKR; a sentinel kinase for cellular stressQ28137774
Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alphaQ28142640
GTP binding by class II transactivator: role in nuclear importQ28143079
Stat protein transactivation domains recruit p300/CBP through widely divergent sequencesQ28143105
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infectionQ28144181
MEKK1 binds raf-1 and the ERK2 cascade componentsQ28145204
Virus interference. I. The interferonQ28181608
Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250Q28199910
The polyoma virus T antigen interferes with interferon-inducible gene expressionQ35791333
The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokinesQ35886322
Transcription factors induced by interferons alpha and gammaQ35888238
Interferon gamma-induced transcription of the murine ISGF3gamma (p48) gene is mediated by novel factorsQ35901315
Cells resistant to interferon are defective in activation of a promoter-binding factor.Q35996080
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosisQ36084388
STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activitiesQ36091763
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in miceQ36173122
Stat1-independent regulation of gene expression in response to IFN-gammaQ36231607
Biologic consequences of Stat1-independent IFN signaling.Q36231950
The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activationQ36335491
Role of interferon regulatory factor 1 in induction of nitric oxide synthaseQ36363736
Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosisQ36376889
Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expressionQ36380813
Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathwayQ36400431
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent miceQ36497106
Identification of a yeast artificial chromosome clone encoding an accessory factor for the human interferon gamma receptor: evidence for multiple accessory factorsQ36550063
Ligand-induced association of the type I interferon receptor componentsQ36553478
Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase responseQ36559345
Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140.Q36561393
The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domainQ36567620
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteinsQ36570254
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosisQ36571893
The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-mycQ36652856
Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificityQ36658770
Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcriptionQ36659852
A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoterQ36659988
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptorQ36662265
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule bindsQ36689696
Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interactionQ36689762
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathwayQ36704173
Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cellsQ36705872
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of eitherQ36709682
On the role of IRF in host defenseQ28201598
Control of IRF-3 activation by phosphorylationQ28201609
Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulationQ28201619
IRF-4 activities in HTLV-I-induced T cell leukemogenesisQ28201628
ICSBP/IRF-8: its regulatory roles in the development of myeloid cellsQ28201638
The bare lymphocyte syndrome and the regulation of MHC expressionQ28204378
EnhanceosomesQ28204862
Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cellsQ28204912
Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulatorsQ28205038
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1Q28215945
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemiaQ28253771
The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor proteinQ28255013
Specific inhibition of Stat3 signal transduction by PIAS3Q28255665
Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasiaQ28266438
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cellsQ28276215
Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alphaQ28277620
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcriptionQ28287446
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzymeQ28287610
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alphaQ28289207
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruptionQ28290282
Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alphaQ28292603
A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitroQ28296697
Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon actionQ28297833
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gammaQ28298440
A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infectionQ28299361
Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infectionQ28299370
Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factorsQ28302411
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shockQ28307404
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinaseQ30450248
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathwayQ30452664
Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.Q30598957
CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel elementQ30860699
CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma ) gene transcription in human monocytic cellsQ30987795
The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factorQ31076639
Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATsQ31813086
Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).Q33541966
An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genesQ33582885
Virus interception of cytokine-regulated pathwaysQ33601962
Immunoregulatory properties of ISG15, an interferon-induced cytokineQ33610088
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6Q33630682
Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300.Q33649357
MAP kinase pathwaysQ33650641
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responsesQ33771205
Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acidQ33781496
Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53Q33834993
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chainsQ33877936
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaBQ33886023
STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gammaQ33887011
RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon responseQ33893743
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).Q33894724
Interferons and cell growth controlQ33917579
Partial impairment of cytokine responses in Tyk2-deficient miceQ33924660
Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell functionQ33924665
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcriptionQ33938819
SUMO, ubiquitin's mysterious cousinQ33939449
The role of STATs in transcriptional control and their impact on cellular functionQ33941346
Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53Q33957610
Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorderQ33961815
Inhibition of p300 histone acetyltransferase by viral interferon regulatory factorQ33966269
Novel functions of interferon-induced proteinsQ33998145
Second-generation interferons for cancer: clinical targetsQ33998161
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gammaQ34030536
Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferonQ36727058
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.Q36735213
A nuclear tyrosine phosphatase downregulates interferon-induced gene expressionQ36827566
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.Q36967719
IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages.Q37142588
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alphaQ37166522
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathwaysQ37354287
Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNAQ37467119
Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formationQ37583264
Repression of the interferon signal transduction pathway by the adenovirus E1A oncogeneQ37590901
Stat1 depends on transcriptional synergy with Sp1.Q38287839
Concerted participation of NF-kappa B and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liverQ38297326
The myxoma virus-soluble interferon-gamma receptor homolog, M-T7, inhibits interferon-gamma in a species-specific mannerQ38298667
Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferonQ38299121
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophagesQ38299607
An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferonsQ38299652
Genomic organization and transcriptional regulation of human Apo2/TRAIL gene.Q38306226
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 geneQ38309989
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte developmentQ38315288
Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon systemQ38317411
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferonsQ38319422
Activation of the p38 mitogen-activated protein kinase by type I interferonsQ38319686
Interleukin-6 induces the (2'-5') oligoadenylate synthetase gene in M1 cells through an effect on the interferon-responsive enhancerQ38336338
Regulation of HIV-1 long terminal repeats by interaction of C/EBP(NF-IL6) and NF-kappaB/Rel transcription factors.Q38353132
CCAAT box enhancer binding protein alpha (C/EBP-alpha) stimulates kappaB element-mediated transcription in transfected cellsQ38360591
Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor.Q38361181
Regulation of interferon-beta gene: structure and function of cis-elements and trans-acting factorsQ38750326
Cooperation of STAT-1 and IRF-1 in interferon-gamma-induced transcription of the gp91(phox) geneQ39152033
Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.Q39446101
Interferon consensus sequence binding protein confers resistance against Yersinia enterocoliticaQ39514613
Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcriptionQ39589711
Escape of human cytomegalovirus from HLA-DR-restricted CD4(+) T-cell response is mediated by repression of gamma interferon-induced class II transactivator expressionQ39595303
The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradationQ39596942
Interferon action against human parainfluenza virus type 3: involvement of a novel antiviral pathway in the inhibition of transcriptionQ39602796
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activationQ34086182
Structure and function of IRF-7.Q34114255
Interferon in oncological practice: review of interferon biology, clinical applications, and toxicitiesQ34132119
The human interferon alpha species and receptorsQ34136286
Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chainQ34219840
The interferon system and interferon regulatory factor transcription factors -- studies from gene knockout miceQ34234067
A weak signal for strong responses: interferon-alpha/beta revisitedQ34238056
Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.Q34244880
Cloning of murine interferon gamma receptor cDNA: expression in human cells mediates high-affinity binding but is not sufficient to confer sensitivity to murine interferon gammaQ34325708
Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathwaysQ34325874
Disturbance of tumor necrosis factor alpha-mediated beta interferon signaling in cervical carcinoma cellsQ34326864
Interferon-alfa-based treatment of chronic myeloid leukemia and implications of signal transduction inhibitionQ34349068
Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptorQ34378837
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitorQ34379342
Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis.Q34383407
A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligasesQ34455419
Signal integration via PKR.Q34467907
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activityQ34532143
Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 functionQ34532718
Enhancement and diversification of IFN induction by IRF-7-mediated positive feedbackQ34532725
The role of IRF-4 in B and T cell activation and differentiationQ34532740
The role of IRF-4 in transcriptional regulationQ34532748
ICSBP/IRF-8 transactivation: a tale of protein-protein interactionQ34532757
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factorQ34679479
Cytokine therapeutics: lessons from interferon alphaQ35033232
Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53.Q35197148
Cytokine triggered molecular pathways that control cell cycle arrestQ35345229
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.Q35358944
Retracted: Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptorsQ35656534
Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogeneQ35776542
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.Q52174469
The role of C/EBP genes in adipocyte differentiation.Q52182559
Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth.Q52192519
Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice.Q52199698
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.Q52507356
Type I IFN modulates innate and specific antiviral immunity.Q52920823
ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages.Q53437189
Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1.Q53517183
Nuclease-resistant composite 2',5'-oligoadenylate-3', 5'-oligonucleotides for the targeted destruction of RNA: 2-5A-iso-antisense.Q54137592
Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN gamma receptors.Q54196124
Partial Interferon‐γ Receptor Signaling Chain Deficiency in a Patient with Bacille Calmette‐Guérin andMycobacterium abscessusInfectionQ56941623
Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferonsQ57054948
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitroQ57055052
The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity FunctionsQ57272895
Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by HyperphosphorylationQ58197205
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimerasQ58666576
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytesQ59067290
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damageQ59081725
α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequencesQ59089879
Interferon-gamma-Induced MHC Class I Expression and Defects in Jak/Stat Signalling in Methylcholanthrene-Induced SarcomasQ61698896
Immune response in mice that lack the interferon-gamma receptorQ62022366
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factorQ68007089
A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNAQ68033053
Cloning members of protein-tyrosine kinase family using polymerase chain reactionQ68065035
JAK2, a third member of the JAK family of protein tyrosine kinasesQ68187981
Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytesQ71143996
Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathwayQ71468319
Induction of the C/EBP beta gene by dexamethasone and glucagon in primary-cultured rat hepatocytesQ71586807
Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteinsQ71768175
The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domainQ72351854
Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta)Q72999285
Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinasesQ73041199
The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinaseQ73085064
Nuclear receptor coactivatorsQ73153183
CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signalingQ73291750
Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITAQ73398802
Multistage regulation of Th1-type immune responses by the transcription factor IRF-1Q73479951
Interferon regulatory factor-1 is required for a T helper 1 immune response in vivoQ73479956
Signaling pathways to the assembly of an interferon-beta enhanceosome. Chemical genetic studies with a small moleculeQ73626309
Impaired alpha-interferon signaling in transitional cell carcinoma: lack of p48 expression in 5637 cellsQ73698382
HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivatorsQ73787690
Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domainsQ73943058
The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteinsQ73947973
Interferon-alpha promotes survival of human primary B-lymphocytes via phosphatidylinositol 3-kinaseQ73987475
Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophagesQ74165184
A role for NF-kappa B in the induction of beta-R1 by interferon-betaQ74601721
Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoterQ77522390
Precursor processing of pro-ISG15/UCRP, an interferon-beta-induced ubiquitin-like proteinQ78151565
Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4Q95793006
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathwaysQ39646499
Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferonsQ39748096
Role of STAT2 in the alpha interferon signaling pathwayQ40015757
Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophagesQ40016551
Ligand-induced assembly and activation of the gamma interferon receptor in intact cellsQ40019119
C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoterQ40019700
Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latencyQ40020928
Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinaseQ40023873
Regulation of the interferon-induced PKR: can viruses cope?Q40399961
Cytokine receptor signallingQ40416594
Signaling through the hematopoietic cytokine receptors.Q40444894
Cytokine signal transduction and the JAK family of protein tyrosine kinasesQ40668096
The virus-induced factor VIF differentially recognizes the virus-responsive modules of the mouse IFNA4 gene promoterQ40750832
A non-classical ISRE/ISGF3 pathway mediates induction of RANTES gene transcription by type I IFNsQ40753511
Role of nucleoporin induction in releasing an mRNA nuclear export blockQ40754912
Specific inhibition of interferon signal transduction pathways by adenoviral infectionQ40773522
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutationQ40792689
The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.Q40808240
ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gammaQ40854135
Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infectionQ40863327
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathwaysQ40874268
Interferon-dependent activation of the serine kinase PI 3'-kinase requires engagement of the IRS pathway but not the Stat pathwayQ40891423
Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signalingQ40990146
Activation of Raf-1 by interferon gamma and oncostatin M requires expression of the Stat1 transcription factorQ41024206
Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independentQ41063440
Differential use of CREB binding protein-coactivator complexesQ41064392
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspasesQ41075291
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.Q41078584
Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48-ISGF3gamma.Q41082105
Targeted inhibition of interferon-gamma-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1.Q41082118
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptorQ41109044
Induction of MHC class I expression by the MHC class II transactivator CIITA.Q41112935
Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfismQ41120368
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
P304page(s)1-29
P577publication date2003-10-01
P1433published inPharmacology & TherapeuticsQ3378596
P1476titleAlternate interferon signaling pathways
P478volume100

Reverse relations

cites work (P2860)
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