Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). (scientific article)

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P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

943-948

P577

publication date

2002-01-08

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

P478

volume

Reverse relations

cites work (P2860)

Q35556098	Alternate interferon signaling pathways
Q34126053	Cytokine signaling in 2002: new surprises in the Jak/Stat pathway
Q62819378	Defining Control
Q33771100	Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve
Q84580749	Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity
Q37885161	Drug discovery for polycystic kidney disease
Q38837265	Inflammation and Fibrosis in Polycystic Kidney Disease
Q97526674	Integrate Molecular Phenome and Polygenic Interaction to Detect the Genetic Risk of Ischemic Stroke
Q36231107	Negative regulation of cytokine and TLR signalings by SOCS and others
Q81133805	Negative regulation of cytokine signaling
Q24816896	Negative regulation of cytokine signaling and immune responses by SOCS proteins
Q37421222	Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung
Q53958174	Pathways, perspectives and pursuits in polycystic kidney disease.
Q36119606	Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells
Q36713986	Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2
Q36209324	Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins.
Q26852136	Regulation of STATs by polycystin-1 and their role in polycystic kidney disease
Q35630518	Regulation of TLR signaling and inflammation by SOCS family proteins
Q35096707	Regulation of cytokine receptor signaling by SOCS1.
Q34830660	Regulation of cytokine signaling and inflammation
Q36810972	Renal tuberculosis in adult polycystic kidney disease: report of 2 cases and review of the literature
Q38124037	SOCS proteins in development and disease
Q36403649	SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
Q33877757	SOCS1 is a negative regulator of metabolic reprogramming during sepsis
Q46987988	SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions.
Q78518643	SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
Q50125557	SOCS1: Regulator of T Cells in Autoimmunity and Cancer.
Q36383865	SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.
Q36731660	SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function
Q29547776	Stats: transcriptional control and biological impact
Q38171193	Strategies targeting cAMP signaling in the treatment of polycystic kidney disease
Q79073423	Suppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity
Q39273551	Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells.
Q34967884	Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
Q39646238	Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
Q34279168	Suppressors of cytokine signaling and immunity
Q36050382	Suppressors of cytokine signaling in health and disease
Q34716329	Suppressors of cytokine signalling (SOCS) in the immune system
Q37728927	Synergistic and feedback signaling mechanisms in the regulation of inflammation in respiratory infections
Q54115189	The molecular basis of JAK/STAT inhibition by SOCS1.
Q27026783	The role of suppressors of cytokine signalling in human neoplasms
Q64054927	Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer
Q36977367	miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1

P819	ADS bibcode	2002PNAS...99..943M
P356	DOI	10.1073/PNAS.022628499
P932	PMC publication ID	117410
P698	PubMed publication ID	11782537
P5875	ResearchGate publication ID	11574848