Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity

scientific article published on 01 November 2010

Differential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GLIA.21051
P698PubMed publication ID20645407

P2093author name stringBradley J Kerr
Howard M Johnson
Samuel David
Jennifer L Berard
P2860cites workThe comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signalingQ46941042
SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activationQ47406323
Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.Q54626145
Failure of sensory neurons to express class I MHC is due to differential SOCS1 expressionQ62675334
Expression of ?suppressor of cytokine signalling? (SOCS) genes in the developing and adult mouse nervous systemQ62675369
Differential expression of suppressors of cytokine signaling-1 and -3 and related cytokines in central nervous system during remitting versus non-remitting forms of experimental autoimmune encephalomyelitis.Q64948037
Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitroQ68601076
Galectin-3/MAC-2 in experimental allergic encephalomyelitisQ73320823
SOCS1 regulates interferon-gamma mediated sensory neuron survivalQ77322591
SOCS1/JAB is a negative regulator of LPS-induced macrophage activationQ78518643
SOCS-1 participates in negative regulation of LPS responsesQ78518680
Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and SmadsQ80825258
Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microgliaQ81613971
A family of cytokine-inducible inhibitors of signallingQ24313168
A new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammationQ28266133
Structure and function of a new STAT-induced STAT inhibitorQ28584775
Nitric oxide and macrophage functionQ29615327
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient miceQ31949951
Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerveQ33771100
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).Q33894724
Genetic models for CNS inflammationQ34139624
Local nitric oxide production in viral and autoimmune diseases of the central nervous systemQ34209628
Suppressors of cytokine signaling and immunityQ34279168
Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.Q34507928
Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.Q34674896
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Transcription factors in the pathogenesis of autoimmunityQ35724197
Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitisQ35788671
SOCS: role in inflammation, allergy and homeostasisQ35846396
Cytokines in multiple sclerosis: from bench to bedsideQ36113477
Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cellsQ36231527
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.Q36735213
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblastsQ36975390
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteinsQ37257006
An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharideQ38349380
Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune responsesQ40000317
Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsingQ40364719
A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.Q40462635
Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 functionQ40547454
Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generationQ40660108
Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophagesQ40708938
The IL-23/IL-17 axis in inflammationQ42825302
Low responsiveness to IFN-gamma, after pretreatment of mouse macrophages with lipopolysaccharides, develops via diverse regulatory pathwaysQ43900082
Peptidylprolyl isomerase A (PPIA) as a preferred internal control over GAPDH and beta-actin in quantitative RNA analysesQ43965355
Regulation of the expression of inducible nitric oxide synthaseQ45089049
Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection.Q45757124
P433issue15
P304page(s)1816-1826
P577publication date2010-11-01
P1433published inGliaQ15716658
P1476titleDifferential expression of SOCS1 in macrophages in relapsing-remitting and chronic EAE and its role in disease severity
P478volume58

Reverse relations

cites work (P2860)
Q44596853A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis
Q36131241Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats.
Q59134975Connexin 30 Deficiency Attenuates Chronic but Not Acute Phases of Experimental Autoimmune Encephalomyelitis Through Induction of Neuroprotective Microglia
Q35154391Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.
Q35175890Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis
Q55026303Intravenous C16 and angiopoietin-1 improve the efficacy of placenta-derived mesenchymal stem cell therapy for EAE.
Q33988247Involvement of the janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis.
Q38201907Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis
Q37325616Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination.
Q49543789Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway.
Q37670027Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases.
Q37889633Repertoire of microglial and macrophage responses after spinal cord injury
Q48413880Role of brain transmigrating neutrophils in depression-like behavior during systemic infection.
Q38067258Role of the SOCS in monocytes/macrophages-related pathologies. Are we getting closer to a new pharmacological target?
Q34645350The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis

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