Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts

scientific article published on November 1, 2003

Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.ABB.2003.08.013
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0003986103004399?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0003986103004399?httpAccept=text/xml
P698PubMed publication ID14568006

P50authorPaul J ThornalleyQ56810389
P2860cites workAmerican Journal of PhysiologyQ2160146
Cellular and Molecular BiologyQ15749453
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?Q23918618
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirinQ28185699
Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicalsQ28328519
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
Diabetic retinopathyA clinical updateQ30875448
Mechanisms underlying endothelial dysfunction in diabetes mellitusQ31829307
Renoprotective effects of a novel inhibitor of advanced glycationQ32019989
Oxidative DNA damage induced by high glucose and its suppression in human umbilical vein endothelial cellsQ34086946
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linkingQ34180583
Early cellular and molecular changes induced by diabetes in the retinaQ34338727
The glyoxalase system in health and diseaseQ34347556
Aminoguanidine ameliorates albuminuria in diabetic hypertensive ratsQ34352122
Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic ratsQ71909295
Secondary intervention with aminoguanidine retards the progression of diabetic retinopathy in the rat modelQ72053237
The reaction of d-glucose with aminoguanidineQ72112610
Toxicity of mildly modified low-density lipoproteins to cultured retinal capillary endothelial cells and pericytesQ72150719
Aminoguanidine does not inhibit the initial phase of experimental diabetic retinopathy in ratsQ72258248
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive ratQ72345792
Glycation, glycoxidation, and cross-linking of collagen by glucose. Kinetics, mechanisms, and inhibition of late stages of the Maillard reactionQ72387391
The effect of aminoguanidine and tolrestat on glucose toxicity in bovine retinal capillary pericytesQ72462727
Aminoguanidine: a drug proposed for prophylaxis in diabetes inhibits catalase and generates hydrogen peroxide in vitroQ72547279
The pharmacokinetics of aminoguanidine in end-stage renal disease patients on hemodialysisQ72582677
Effects of aminoguanidine on insulin release from pancreatic isletsQ72782649
Effects of aminoguanidine on serum advanced glycation endproducts, urinary albilmin excretion, mesangial expansion, and glomerular basement membrane thickening in Otsuka Long-Evans Tokushima fatty ratsQ73153631
Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase CQ73313410
Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve functionQ73443357
AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cellsQ73634250
Efficient scavenging of fatty acid oxidation products by aminoguanidineQ73664088
Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic ratsQ73829192
Aminoguanidine inhibits semicarbazide-sensitive amine oxidase activity: implications for advanced glycation and diabetic complicationsQ73922976
In vivo formation of a Schiff base of aminoguanidine with pyridoxal phosphateQ74674415
Diabetic nephropathy: prevention and treatmentQ77155189
Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic ratsQ77379022
Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic miceQ77730593
Depletion of nitric oxide synthase-containing neurons in the diabetic retina: reversal by aminoguanidineQ77731024
Chronic aminoguanidine attenuates renal dysfunction and injury in aging ratsQ77795012
Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic ratsQ78251590
Advanced glycation end products and the progressive course of renal disease.Q34384751
Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic RatQ34762247
Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic optionsQ34800437
Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiencyQ35788419
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophyQ35805813
Aminoguanidine and the prevention of leukocyte dysfunction in diabetes mellitus: a direct vital microscopic studyQ36893420
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.Q37623293
Aminoguanidine treatment inhibits the development of experimental diabetic retinopathyQ37653146
Hyperglycemic pseudohypoxia and diabetic complications.Q40908737
Aminoguanidine supplementation delays the onset of senescence in vitro in dermal fibroblast-like cells from senescence-accelerated miceQ40933376
Accumulation of alpha-oxoaldehydes during oxidative stress: a role in cytotoxicityQ40940923
DNA modification in vivo by derivatives of glucose: enhancement by glutathione depletionQ41711793
Comparison of antioxidant activities of aminoguanidine, methylguanidine and guanidine by luminol-enhanced chemiluminescenceQ41897633
Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescenceQ42157623
The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins.Q42282865
Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetesQ43543923
Ramipril and aminoguanidine restore renal lysosomal processing in streptozotocin diabetic ratsQ43554898
alpha-Dicarbonyls increase in the postprandial period and reflect the degree of hyperglycemiaQ43584213
Glycation cross-links inhibit matrix metalloproteinase-2 activation in vascular smooth muscle cells cultured on collagen latticeQ43611279
Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytesQ43719975
Effect of chronic aminoguanidine treatment on age-related glycation, glycoxidation, and collagen cross-linking in the Fischer 344 rat.Q43721293
Chelating activity of advanced glycation end-product inhibitorsQ43777338
The effects of aminoguanidine on renal changes in a baboon model of Type 1 diabetesQ44070319
Aminoguanidine pyridoxal adduct is superior to aminoguanidine for preventing diabetic nephropathy in miceQ44110310
Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathyQ44195281
ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.Q44195285
Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in ratsQ44245954
Effect of dietary aminoguanidine on tissue pentosidine and reproductive performance in broiler breeder hensQ45107517
Formation of reactive intermediates from Amadori compounds under physiological conditionsQ47632318
Effect of aminoguanidine on optic nerve involvement in experimental diabetic ratsQ47759542
Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosisQ47904015
The nitric oxide hypothesis of agingQ48287971
Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions.Q52078784
Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster.Q52563298
Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II).Q53540821
Rapid induction of messenger RNA for nitric oxide synthase II in rat neutrophils in vivo by endotoxin and its suppression by prednisolone.Q54639650
Nitric oxide synthases: structure, function and inhibitionQ55951119
Effects of heparin and aminoguanidine on glomerular basement membrane thickening in diabetic ratsQ60724001
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to N∊-carboxymethyl-lysine- and N∊-(1-carboxyethyl)lysine-modified albuQ60786605
The reaction of some dicarbonyl sugars with aminoguanidineQ67573548
Aminoguanidine treatment reduces the increase in collagen stability of rats with experimental diabetes mellitusQ68065335
3-Deoxy-L-glycero-pentos-2-ulose (3-deoxy-L-xylosone) and L-threo-pentos-2-ulose (L-xylosone) as intermediates in the degradation of L-ascorbic acidQ70265291
Aminoguanidine inhibits protein browning without extensive Amadori carbonyl blockingQ70658685
Effect of aminoguanidine on the frequency of neuroaxonal dystrophy in the superior mesenteric sympathetic autonomic ganglia of rats with streptozocin-induced diabetesQ70983840
Inhibition of cataracts in moderately diabetic rats by aminoguanidineQ71402808
Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthaseQ71671331
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectbiochemistryQ7094
biophysicsQ7100
P1104number of pages10
P304page(s)31-40
P577publication date2003-11-01
P1433published inArchives of Biochemistry and BiophysicsQ635818
P1476titleUse of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts
P478volume419

Reverse relations

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