Core features of frontotemporal dementia recapitulated in progranulin knockout mice

scientific article published on 10 September 2011

Core features of frontotemporal dementia recapitulated in progranulin knockout mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NBD.2011.08.029
P8608Fatcat IDrelease_yyk4rynxdzdefitzdy4d6srhue
P932PMC publication ID3225509
P698PubMed publication ID21933710
P5875ResearchGate publication ID51657592

P2093author name stringN J Cairns
D F Wozniak
J T Dearborn
N Ghoshal
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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21Q28253639
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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degenerationQ30490978
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Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effectsQ30670738
HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulinQ33576895
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient miceQ33615151
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar DegenerationQ33685317
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful agingQ33947272
Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's DiseaseQ33955976
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degenerationQ33999208
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an updateQ34020227
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementiaQ34352771
A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).Q35501862
The granulin gene family: from cancer to dementiaQ37606400
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulinQ39838808
Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementiaQ42478217
Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal culturesQ42871327
Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical culturesQ43861982
Effects of age on mortality and antibiotic efficacy in cecal ligation and punctureQ44399042
The efficiency of systematic sampling in stereology and its prediction.Q44974729
Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adultsQ45168372
Survival in progressive supranuclear palsy and frontotemporal dementiaQ48251313
Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutationQ48255267
Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 familiesQ48315851
Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's diseaseQ48448000
Tau-66: evidence for a novel tau conformation in Alzheimer's diseaseQ48858275
Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in ratsQ48907992
Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.Q50889609
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.Q51973117
Thalamic atrophy and cognition in multiple sclerosisQ81310729
P433issue1
P921main subjectknockout mouseQ1364740
frontotemporal dementiaQ18592
dementiaQ83030
P304page(s)395-408
P577publication date2011-09-10
P1433published inNeurobiology of DiseaseQ15716606
P1476titleCore features of frontotemporal dementia recapitulated in progranulin knockout mice
P478volume45

Reverse relations

cites work (P2860)
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