scholarly article | Q13442814 |
P356 | DOI | 10.1016/J.NBD.2011.08.029 |
P8608 | Fatcat ID | release_yyk4rynxdzdefitzdy4d6srhue |
P932 | PMC publication ID | 3225509 |
P698 | PubMed publication ID | 21933710 |
P5875 | ResearchGate publication ID | 51657592 |
P2093 | author name string | N J Cairns | |
D F Wozniak | |||
J T Dearborn | |||
N Ghoshal | |||
P2860 | cites work | Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study | Q24655242 |
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 | Q28253639 | ||
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Q28253651 | ||
Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria | Q29614410 | ||
Development of a mouse test for repetitive, restricted behaviors: relevance to autism | Q30490689 | ||
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration | Q30490978 | ||
The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus | Q30497056 | ||
Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects | Q30670738 | ||
HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin | Q33576895 | ||
Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice | Q33615151 | ||
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Q33685317 | ||
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging | Q33947272 | ||
Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease | Q33955976 | ||
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration | Q33999208 | ||
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update | Q34020227 | ||
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia | Q34352771 | ||
A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). | Q35501862 | ||
The granulin gene family: from cancer to dementia | Q37606400 | ||
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin | Q39838808 | ||
Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia | Q42478217 | ||
Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures | Q42871327 | ||
Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures | Q43861982 | ||
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture | Q44399042 | ||
The efficiency of systematic sampling in stereology and its prediction. | Q44974729 | ||
Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults | Q45168372 | ||
Survival in progressive supranuclear palsy and frontotemporal dementia | Q48251313 | ||
Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation | Q48255267 | ||
Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families | Q48315851 | ||
Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease | Q48448000 | ||
Tau-66: evidence for a novel tau conformation in Alzheimer's disease | Q48858275 | ||
Characterizing learning deficits and hippocampal neuron loss following transient global cerebral ischemia in rats | Q48907992 | ||
Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. | Q50889609 | ||
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. | Q51973117 | ||
Thalamic atrophy and cognition in multiple sclerosis | Q81310729 | ||
P433 | issue | 1 | |
P921 | main subject | knockout mouse | Q1364740 |
frontotemporal dementia | Q18592 | ||
dementia | Q83030 | ||
P304 | page(s) | 395-408 | |
P577 | publication date | 2011-09-10 | |
P1433 | published in | Neurobiology of Disease | Q15716606 |
P1476 | title | Core features of frontotemporal dementia recapitulated in progranulin knockout mice | |
P478 | volume | 45 |
Q90593924 | AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity |
Q39069506 | ALS/FTLD: experimental models and reality |
Q92569370 | An update on human astrocytes and their role in development and disease |
Q41955482 | Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. |
Q45231223 | Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice |
Q37087755 | Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice |
Q37516116 | Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice |
Q58765250 | Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice |
Q30847257 | Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation |
Q36036743 | Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice |
Q38457811 | FTD and ALS--translating mouse studies into clinical trials |
Q90233074 | Glimepiride Administered in Chow Reversibly Impairs Glucose Tolerance in Mice |
Q28544656 | Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology |
Q47599699 | Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma |
Q36495839 | Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects |
Q93346244 | Inflammation in ALS/FTD pathogenesis |
Q92784143 | Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain |
Q92873402 | Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning |
Q34461044 | Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice |
Q99420895 | Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice |
Q26824221 | Mechanisms of granulin deficiency: lessons from cellular and animal models |
Q33719360 | Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. |
Q26766487 | Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders |
Q34770412 | Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice. |
Q26829009 | Mouse models of frontotemporal dementia |
Q50532320 | Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. |
Q36328461 | Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS. |
Q38942093 | Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells. |
Q36357853 | Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury |
Q36999042 | Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells |
Q39744388 | Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test |
Q36430434 | Progranulin regulates neuronal outgrowth independent of sortilin |
Q47623958 | Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease |
Q36294670 | Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration |
Q36826623 | Progranulin: an emerging target for FTLD therapies |
Q27024421 | Progranulin: at the interface of neurodegenerative and metabolic diseases |
Q36877434 | Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists |
Q93193248 | Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice |
Q38853352 | Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia |
Q87359504 | Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation |
Q34983534 | Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies |
Q46929743 | Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation |
Q64092992 | Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice |
Q47830754 | Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. |
Q28508280 | The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors |
Q38166419 | Unravelling the mysteries of frontotemporal dementia. |
Q42642970 | Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice |
Search more.