| scholarly article | Q13442814 |
| P50 | author | Christian Haass | Q107652 |
| Anja Capell | Q63092243 | ||
| Manuela Neumann | Q66730291 | ||
| P2093 | author name string | Bettina Schmid | |
| Katrin Fellerer | |||
| Sunita S Shankaran | |||
| Alexander T Hruscha | |||
| P2860 | cites work | TDP43 depletion rescues aberrant CFTR exon 9 skipping. | Q51276789 |
| Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. | Q52218193 | ||
| Progranulin in frontotemporal lobar degeneration and neuroinflammation | Q21245242 | ||
| Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping | Q24291081 | ||
| Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) | Q24652242 | ||
| The zebrafish progranulin gene family and antisense transcripts | Q24816085 | ||
| Stages of embryonic development of the zebrafish | Q27860947 | ||
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q28131672 | ||
| Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide | Q28131750 | ||
| Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 | Q28253639 | ||
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Q28253651 | ||
| Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17 | Q28274687 | ||
| Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus | Q28570107 | ||
| Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease | Q30872231 | ||
| Cellular localization of gene expression for progranulin | Q33180554 | ||
| HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin | Q33576895 | ||
| Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43. | Q34601207 | ||
| Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis | Q35203303 | ||
| Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. | Q35667940 | ||
| TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions | Q35928153 | ||
| Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes | Q36227050 | ||
| Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations | Q36728531 | ||
| Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. | Q40075711 | ||
| Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse | Q40176984 | ||
| An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing | Q40589634 | ||
| Structural diversity and functional implications of the eukaryotic TDP gene family | Q40608660 | ||
| Progranulin is a mediator of the wound response | Q40678214 | ||
| Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch | Q40883659 | ||
| TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations | Q42509587 | ||
| Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function | Q46434717 | ||
| TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions | Q48244352 | ||
| TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations | Q48284829 | ||
| The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene | Q48384348 | ||
| Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study | Q48400369 | ||
| Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome | Q48400376 | ||
| Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval | Q48428753 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | frontotemporal lobar degeneration | Q18579 |
| P304 | page(s) | 1744-1753 | |
| P577 | publication date | 2007-11-05 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. | |
| P478 | volume | 283 |
| Q52851529 | A Novel Splice-Acceptor Site Mutation in GRN (c.709-2 A>T) Causes Frontotemporal Dementia Spectrum in a Large Family from Southern Italy. |
| Q35194634 | A network of RNA and protein interactions in Fronto Temporal Dementia |
| Q43101035 | A pollen-specific RALF from tomato that regulates pollen tube elongation |
| Q33624840 | A thorough assessment of benign genetic variability in GRN and MAPT. |
| Q46461914 | Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. |
| Q48388837 | Alzheimer neuropathology without frontotemporal lobar degeneration hallmarks (TAR DNA-binding protein 43 inclusions) in missense progranulin mutation Cys139Arg |
| Q40356383 | Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs |
| Q37879596 | Cellular effects of progranulin in health and disease |
| Q42805112 | Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2. |
| Q39472371 | Circulating progranulin as a biomarker for neurodegenerative diseases |
| Q30541723 | Clinicopathologic variability of the GRN A9D mutation, including amyotrophic lateral sclerosis |
| Q35577194 | Core features of frontotemporal dementia recapitulated in progranulin knockout mice |
| Q91726350 | Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states |
| Q38971962 | Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells. |
| Q36734898 | Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis |
| Q37248850 | Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy. |
| Q37485507 | Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain |
| Q42059392 | Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling |
| Q37241079 | FTD and ALS: a tale of two diseases |
| Q53268278 | Frontotemporal dementia. |
| Q37928504 | Frontotemporal dementia: from Mendelian genetics towards genome wide association studies |
| Q36794765 | Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics |
| Q30503638 | Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration |
| Q38786774 | Genetics of FTLD: overview and what else we can expect from genetic studies |
| Q38027808 | Genetics of dementia: update and guidelines for the clinician |
| Q28544656 | Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology |
| Q81430169 | Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update |
| Q37882469 | Human genetics as a tool to identify progranulin regulators |
| Q34538196 | Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease |
| Q30538184 | Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth |
| Q26824221 | Mechanisms of granulin deficiency: lessons from cellular and animal models |
| Q36003800 | Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration |
| Q36535668 | Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features |
| Q38209473 | Modelling inborn errors of metabolism in zebrafish. |
| Q37209771 | Molecular genetics of Alzheimer's disease: an update |
| Q26829009 | Mouse models of frontotemporal dementia |
| Q48248773 | Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke |
| Q36438687 | No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort |
| Q37235164 | Novel progranulin mutations with reduced serum-progranulin levels in frontotemporal lobar degeneration |
| Q39140598 | Novel progranulin variants do not disrupt progranulin secretion and cleavage |
| Q55439517 | Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency. |
| Q39760142 | Pathogenic cysteine mutations affect progranulin function and production of mature granulins |
| Q64119235 | Precision Medicine for Frontotemporal Dementia |
| Q47548337 | Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. |
| Q37921642 | Progranulin and TDP-43: mechanistic links and future directions |
| Q37978700 | Progranulin axis and recent developments in frontotemporal lobar degeneration |
| Q34916082 | Progranulin expression is upregulated after spinal contusion in mice. |
| Q36527176 | Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival |
| Q35164339 | Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease. |
| Q48137804 | Progranulin increases phagocytosis by retinal pigment epithelial cells in culture |
| Q33513028 | Progranulin is expressed within motor neurons and promotes neuronal cell survival |
| Q33725391 | Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy |
| Q30497278 | Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1 |
| Q36922853 | Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β. |
| Q36430434 | Progranulin regulates neuronal outgrowth independent of sortilin |
| Q34170826 | Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression |
| Q38691811 | Progranulin, lysosomal regulation and neurodegenerative disease |
| Q47623958 | Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease |
| Q36294670 | Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration |
| Q36826623 | Progranulin: an emerging target for FTLD therapies |
| Q38015344 | Recent insights into the involvement of progranulin in frontotemporal dementia. |
| Q33830518 | Recent insights into the molecular genetics of dementia |
| Q93193248 | Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice |
| Q39240888 | Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models. |
| Q41933726 | Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. |
| Q38853352 | Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia |
| Q34642738 | Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration |
| Q37730008 | Role of progranulin as a biomarker for Alzheimer's disease |
| Q33742148 | Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease |
| Q37892442 | Structure, function, and mechanism of progranulin; the brain and beyond |
| Q38096349 | TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update |
| Q37733168 | TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration |
| Q57306362 | TDP-43 in neurodegenerative disorders |
| Q37730909 | TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions |
| Q34555400 | TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. |
| Q36247028 | TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways |
| Q35589301 | TREM2 is associated with increased risk for Alzheimer's disease in African Americans |
| Q28587955 | Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency |
| Q64054884 | The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD |
| Q24615201 | The genetics and neuropathology of frontotemporal lobar degeneration |
| Q37152489 | The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment |
| Q38661883 | The lysosomal protein cathepsin L is a progranulin protease |
| Q37564674 | The molecular basis of frontotemporal dementia |
| Q37593727 | The molecular links between TDP-43 dysfunction and neurodegeneration |
| Q30495415 | The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration |
| Q37254394 | The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. |
| Q41878973 | Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices |
| Q37205729 | Update on recent molecular and genetic advances in frontotemporal lobar degeneration |
| Q37831557 | Zebrafish as a model to understand autophagy and its role in neurological disease |
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