| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1009905540 |
| P356 | DOI | 10.1186/1471-2202-10-130 |
| P932 | PMC publication ID | 2779192 |
| P698 | PubMed publication ID | 19860916 |
| P5875 | ResearchGate publication ID | 38040150 |
| P50 | author | Christopher Shaw | Q21469470 |
| David C Baranowski | Q59694492 | ||
| P2093 | author name string | Suneil Malik | |
| Zhi Li | |||
| Andrew Bateman | |||
| Hugh P J Bennett | |||
| Babykumari P Chitramuthu | |||
| Denis G Kay | |||
| Heather D Durham | |||
| Sandra Minotti | |||
| Mingju Cao | |||
| Cara L Ryan | |||
| P2860 | cites work | Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains | Q24305310 |
| The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription | Q24554329 | ||
| The zebrafish progranulin gene family and antisense transcripts | Q24816085 | ||
| A new mathematical model for relative quantification in real-time RT-PCR | Q27860781 | ||
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q28131672 | ||
| Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo | Q28139070 | ||
| Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 | Q28253639 | ||
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Q28253651 | ||
| Granulins, a novel class of peptide from leukocytes | Q28268552 | ||
| Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line | Q28269288 | ||
| The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth | Q28274290 | ||
| The neuropathology and clinical phenotype of FTD with progranulin mutations | Q28299352 | ||
| Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus | Q28570107 | ||
| Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats | Q28577481 | ||
| Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse | Q28590736 | ||
| TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q29615597 | ||
| Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin | Q30482362 | ||
| Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays | Q30661747 | ||
| Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption | Q30849373 | ||
| The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. | Q31126520 | ||
| Cellular localization of gene expression for progranulin | Q33180554 | ||
| Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development | Q33187938 | ||
| Progranulin genetic variability contributes to amyotrophic lateral sclerosis | Q57838448 | ||
| Progranulin locus deletion in frontotemporal dementia | Q59698065 | ||
| Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex | Q61771857 | ||
| Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium | Q77813507 | ||
| Progranulin null mutations in both sporadic and familial frontotemporal dementia | Q80162804 | ||
| Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis | Q80226812 | ||
| Progranulin is a stress-response factor in fibroblasts subjected to hypoxia and acidosis | Q80229746 | ||
| Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury | Q82791141 | ||
| Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons | Q33282966 | ||
| Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS. | Q33294971 | ||
| Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice | Q33698123 | ||
| Progress in clinical neurosciences: the evidence for ALS as a multisystems disorder of limited phenotypic expression. | Q34477724 | ||
| Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). | Q34586077 | ||
| Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis | Q34611962 | ||
| Prominent phenotypic variability associated with mutations in Progranulin | Q35188858 | ||
| Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis | Q35218689 | ||
| Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo | Q35933131 | ||
| The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset | Q35946550 | ||
| Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes | Q36227050 | ||
| Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival | Q36527176 | ||
| The neuropathology of FTD associated With ALS. | Q37036221 | ||
| The granulin gene family: from cancer to dementia | Q37606400 | ||
| Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis. | Q38315048 | ||
| Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. | Q38326738 | ||
| Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations | Q38392876 | ||
| Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin | Q39838808 | ||
| SMN protects cells against mutant SOD1 toxicity by increasing chaperone activity | Q40061444 | ||
| Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. | Q40075711 | ||
| p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action | Q40114935 | ||
| p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis | Q40171781 | ||
| Regulation of progranulin expression in myeloid cells | Q40250617 | ||
| A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death | Q40484912 | ||
| Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. | Q40486792 | ||
| Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival. | Q40629542 | ||
| PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma | Q40641254 | ||
| Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair | Q40677795 | ||
| Progranulin is a mediator of the wound response | Q40678214 | ||
| Development and characterisation of a glutamate-sensitive motor neurone cell line | Q40881505 | ||
| Biological activities and signaling pathways of the granulin/epithelin precursor | Q40920907 | ||
| Evaluation of the spinal cord neuron X neuroblastoma hybrid cell line NSC-34 as a model for neurotoxicity testing. | Q41586957 | ||
| Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons | Q41616019 | ||
| Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium | Q44678043 | ||
| Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis | Q46888155 | ||
| PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma | Q47192449 | ||
| Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma | Q47616090 | ||
| Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. | Q48183466 | ||
| TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation | Q48255479 | ||
| Clinicopathologic features of frontotemporal dementia with progranulin sequence variation | Q48319928 | ||
| Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus | Q48494802 | ||
| Progranulin (PGRN) expression in ALS: an immunohistochemical study | Q48884390 | ||
| Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. | Q51659718 | ||
| Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. | Q51973117 | ||
| Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor). | Q52171933 | ||
| The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. | Q54601832 | ||
| Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms | Q57042709 | ||
| P304 | page(s) | 130 | |
| P577 | publication date | 2009-10-27 | |
| P1433 | published in | BMC Neuroscience | Q15766477 |
| P1476 | title | Progranulin is expressed within motor neurons and promotes neuronal cell survival | |
| P478 | volume | 10 |
| Q34746889 | A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model |
| Q30498840 | A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells |
| Q42490354 | A progranulin mutation associated with cortico-basal syndrome in an Italian family expressing different phenotypes of fronto-temporal lobar degeneration |
| Q36775677 | Advances in understanding the molecular basis of frontotemporal dementia |
| Q40356383 | Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs |
| Q38882131 | Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women? |
| Q34352771 | Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia |
| Q33941320 | C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking |
| Q37879596 | Cellular effects of progranulin in health and disease |
| Q39472371 | Circulating progranulin as a biomarker for neurodegenerative diseases |
| Q93168931 | Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons |
| Q45873297 | Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration |
| Q59794101 | Disease-modifying effects of metabolic perturbations in ALS/FTLD |
| Q37087755 | Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice |
| Q38971962 | Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells. |
| Q42059392 | Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling |
| Q36053005 | Genetics of the neuronal ceroid lipofuscinoses (Batten disease). |
| Q37377851 | Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways |
| Q34381669 | Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma |
| Q37625611 | Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells |
| Q89578513 | Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon |
| Q38445973 | Identification of biological pathways regulated by PGRN and GRN peptide treatments using transcriptome analysis |
| Q42044690 | Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome |
| Q50901491 | Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration. |
| Q33926457 | Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. |
| Q36495839 | Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects |
| Q36534831 | Insights into the role of progranulin in immunity, infection, and inflammation |
| Q41455989 | Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations |
| Q47271759 | Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point? |
| Q26824221 | Mechanisms of granulin deficiency: lessons from cellular and animal models |
| Q28576650 | Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress |
| Q39035458 | Molecular Genetics of Neurodegenerative Dementias |
| Q50532320 | Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. |
| Q38115191 | Neuronal ceroid lipofuscinosis: impact of recent genetic advances and expansion of the clinicopathologic spectrum |
| Q36328461 | Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS. |
| Q89558182 | Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration |
| Q38942093 | Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells. |
| Q47548337 | Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. |
| Q37978700 | Progranulin axis and recent developments in frontotemporal lobar degeneration |
| Q47988952 | Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation |
| Q28567505 | Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses |
| Q36999042 | Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells |
| Q38814424 | Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo |
| Q35164339 | Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease. |
| Q39744388 | Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test |
| Q34760814 | Progranulin is a chemoattractant for microglia and stimulates their endocytic activity |
| Q30497278 | Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1 |
| Q37359314 | Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling |
| Q30592224 | Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. |
| Q38852127 | Progranulin regulates neurogenesis in the developing vertebrate retina |
| Q36430434 | Progranulin regulates neuronal outgrowth independent of sortilin |
| Q47623958 | Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease |
| Q36294670 | Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration |
| Q36826623 | Progranulin: an emerging target for FTLD therapies |
| Q27024421 | Progranulin: at the interface of neurodegenerative and metabolic diseases |
| Q37485657 | Promoter DNA methylation regulates progranulin expression and is altered in FTLD. |
| Q37720436 | RNA processing pathways in amyotrophic lateral sclerosis |
| Q37733773 | RNA-Seq Analysis of Microglia Reveals Time-Dependent Activation of Specific Genetic Programs following Spinal Cord Injury. |
| Q38015344 | Recent insights into the involvement of progranulin in frontotemporal dementia. |
| Q40902827 | Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia |
| Q93193248 | Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice |
| Q39240888 | Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models. |
| Q41933726 | Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. |
| Q38853352 | Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia |
| Q36708664 | Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL) |
| Q34346014 | Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. |
| Q88586037 | Structure dissection of zebrafish progranulins identifies a well-folded granulin/epithelin module protein with pro-cell survival activities |
| Q37892442 | Structure, function, and mechanism of progranulin; the brain and beyond |
| Q28587955 | Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency |
| Q28642185 | The Evolution of the Secreted Regulatory Protein Progranulin |
| Q38555411 | The Role of PGRN in Alzheimer's Disease |
| Q24615201 | The genetics and neuropathology of frontotemporal lobar degeneration |
| Q56594618 | The lysosomal function of progranulin, a guardian against neurodegeneration |
| Q38661883 | The lysosomal protein cathepsin L is a progranulin protease |
| Q26998919 | Therapeutic and diagnostic challenges for frontotemporal dementia |
| Q42642970 | Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice |
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