| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1010835750 |
| P356 | DOI | 10.1186/ALZRT102 |
| P932 | PMC publication ID | 3372369 |
| P698 | PubMed publication ID | 22277331 |
| P5875 | ResearchGate publication ID | 221777453 |
| P50 | author | Rosa Rademakers | Q28777946 |
| Leonard Petrucelli | Q61643074 | ||
| P2093 | author name string | Alexandra M Nicholson | |
| Jennifer Gass | |||
| P2860 | cites work | Progranulin in frontotemporal lobar degeneration and neuroinflammation | Q21245242 |
| Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains | Q24305310 | ||
| Classification of primary progressive aphasia and its variants | Q24594803 | ||
| A harmonized classification system for FTLD-TDP pathology | Q24630756 | ||
| A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD | Q24634583 | ||
| Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q28131672 | ||
| Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo | Q28139070 | ||
| Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 | Q28253639 | ||
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Q28253651 | ||
| Progranulin: normal function and role in neurodegeneration | Q28254281 | ||
| Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17 | Q28274687 | ||
| Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography | Q28302409 | ||
| Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses | Q28567505 | ||
| Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria | Q29614410 | ||
| Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein | Q29619232 | ||
| Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions | Q30434949 | ||
| Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin | Q30482362 | ||
| Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1 | Q30497278 | ||
| A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells | Q30498840 | ||
| The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro. | Q32048245 | ||
| Cellular localization of gene expression for progranulin | Q33180554 | ||
| Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development | Q33187938 | ||
| Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population. | Q33511759 | ||
| Progranulin is expressed within motor neurons and promotes neuronal cell survival | Q33513028 | ||
| GRN variability contributes to sporadic frontotemporal lobar degeneration | Q33522914 | ||
| HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin | Q33576895 | ||
| Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice | Q33615151 | ||
| Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly | Q33808785 | ||
| Recent insights into the molecular genetics of dementia | Q33830518 | ||
| Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia | Q33859252 | ||
| C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking | Q33941320 | ||
| Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging | Q33947272 | ||
| Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease | Q33955976 | ||
| The prevalence of frontotemporal dementia | Q33959615 | ||
| Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration | Q33999208 | ||
| De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis | Q34070072 | ||
| Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. | Q34346014 | ||
| Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia | Q34352771 | ||
| Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma | Q34381669 | ||
| TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. | Q34555400 | ||
| Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels | Q34959322 | ||
| The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice | Q35014661 | ||
| Clinical features of frontotemporal dementia | Q36326654 | ||
| Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival | Q36527176 | ||
| Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling | Q36787346 | ||
| Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β. | Q36922853 | ||
| Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia | Q36967985 | ||
| Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members | Q37148011 | ||
| Emerging roles for centromeres in meiosis I chromosome segregation | Q37256638 | ||
| VPS10P-domain receptors - regulators of neuronal viability and function. | Q37323348 | ||
| The Vps10p-domain receptor family. | Q37478180 | ||
| The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation | Q37773764 | ||
| TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration | Q38382616 | ||
| Pathogenic cysteine mutations affect progranulin function and production of mature granulins | Q39760142 | ||
| Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin | Q39838808 | ||
| Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. | Q40075711 | ||
| Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair | Q40677795 | ||
| Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies. | Q41740121 | ||
| Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. | Q41933726 | ||
| Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling | Q42059392 | ||
| Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis | Q42687225 | ||
| Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures | Q42871327 | ||
| Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease. | Q43298473 | ||
| Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures | Q43861982 | ||
| Mutant valosin-containing protein causes a novel type of frontotemporal dementia | Q45283163 | ||
| Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia | Q46722751 | ||
| Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease | Q46813677 | ||
| The overlap of amyotrophic lateral sclerosis and frontotemporal dementia | Q46924395 | ||
| No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration | Q47789674 | ||
| Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia | Q48250357 | ||
| The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene | Q48384348 | ||
| Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. | Q50889609 | ||
| Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. | Q51973117 | ||
| Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation. | Q53250521 | ||
| An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population. | Q53298201 | ||
| rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population. | Q53315769 | ||
| Progranulin genetic variability contributes to amyotrophic lateral sclerosis | Q57838448 | ||
| Progranulin locus deletion in frontotemporal dementia | Q59698065 | ||
| Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update | Q81430169 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | frontotemporal lobar degeneration | Q18579 |
| P304 | page(s) | 4 | |
| P577 | publication date | 2012-01-23 | |
| P1433 | published in | Alzheimers Research & Therapy | Q15716761 |
| P1476 | title | Progranulin axis and recent developments in frontotemporal lobar degeneration | |
| P478 | volume | 4 |
| Q36189372 | Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner |
| Q39017699 | Genetics of Frontotemporal Dementia |
| Q33815765 | Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations |
| Q38611308 | Lysosomal processing of progranulin |
| Q33631744 | PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistance |
| Q55439517 | Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency. |
| Q89698701 | Progranulin: Functions and neurologic correlations |
| Q47830754 | Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. |
| Q46958756 | The Genetics of Monogenic Frontotemporal Dementia |
| Q48235284 | The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C. |
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