| scholarly article | Q13442814 |
| P50 | author | Rosa Rademakers | Q28777946 |
| Leonard Petrucelli | Q61643074 | ||
| P2093 | author name string | Hiroki Sasaguri | |
| Yong-Jie Zhang | |||
| Fen-Biao Gao | |||
| Sandra Almeida | |||
| Mercedes Prudencio | |||
| Jeannie Chew | |||
| Caroline T. Stetler | |||
| Ian R. Mackenzie | |||
| Karen R. Jansen-West | |||
| NiCole Finch | |||
| Peter O. Bauer | |||
| Tania F. Gendron | |||
| Thomas R. Caulfield | |||
| William M. Tay | |||
| Wing C. Lee | |||
| P2860 | cites work | The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor | Q22003873 |
| Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase | Q22009071 | ||
| LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress | Q24294466 | ||
| The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin | Q24594134 | ||
| Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain | Q27653332 | ||
| Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis | Q28201181 | ||
| Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21 | Q28253639 | ||
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Q28253651 | ||
| Sortilin mediates the lysosomal targeting of cathepsins D and H | Q28284124 | ||
| Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography | Q28302409 | ||
| Reaching for high-hanging fruit in drug discovery at protein-protein interfaces | Q29547258 | ||
| Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells | Q29615870 | ||
| Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons | Q29616199 | ||
| Relating protein pharmacology by ligand chemistry | Q29617492 | ||
| Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin | Q30482362 | ||
| Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1 | Q30497278 | ||
| Progranulin is expressed within motor neurons and promotes neuronal cell survival | Q33513028 | ||
| Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy | Q33725391 | ||
| Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia | Q33859252 | ||
| C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking | Q33941320 | ||
| Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration | Q33999208 | ||
| Characteristics of frontotemporal dementia patients with a Progranulin mutation | Q34330746 | ||
| Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. | Q34346014 | ||
| Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma | Q34381669 | ||
| Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells. | Q34649787 | ||
| Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage | Q36017101 | ||
| What can cell biology tell us about heterogeneity in lysosomal storage diseases? | Q36128577 | ||
| Progranulin regulates neuronal outgrowth independent of sortilin | Q36430434 | ||
| The sorting and trafficking of lysosomal proteins | Q36476133 | ||
| Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects | Q36495839 | ||
| Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor | Q36504281 | ||
| Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival | Q36527176 | ||
| A TALEN genome-editing system for generating human stem cell-based disease models | Q36604889 | ||
| Neutrophil-derived serine proteases modulate innate immune responses. | Q37410443 | ||
| The granulin gene family: from cancer to dementia | Q37606400 | ||
| Structure, function, and mechanism of progranulin; the brain and beyond | Q37892442 | ||
| Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations | Q38392876 | ||
| Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. | Q39994567 | ||
| Progranulin is a mediator of the wound response | Q40678214 | ||
| Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. | Q41933726 | ||
| Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer. | Q42481718 | ||
| The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding. | Q43552781 | ||
| Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study. | Q51967426 | ||
| Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. | Q51973117 | ||
| Heterogeneity within a large kindred with frontotemporal dementia: A novel progranulin mutation | Q57419060 | ||
| Purification of the neurotensin receptor from mouse brain by affinity chromatography | Q69334555 | ||
| Progranulin mutations in Dutch familial frontotemporal lobar degeneration | Q79573361 | ||
| Progranulin null mutations in both sporadic and familial frontotemporal dementia | Q80162804 | ||
| Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update | Q81430169 | ||
| P433 | issue | 6 | |
| P921 | main subject | Haploinsufficiency | Q852654 |
| Sortilin 1 | Q21990393 | ||
| P304 | page(s) | 1467–1478 | |
| P577 | publication date | 2014-03-15 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency | |
| P478 | volume | 23 |
| Q90593924 | AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity |
| Q92232193 | An update on genetic frontotemporal dementia |
| Q93168931 | Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons |
| Q90591149 | Development of disease-modifying drugs for frontotemporal dementia spectrum disorders |
| Q36036743 | Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice |
| Q37044191 | Lateral Temporal Lobe: An Early Imaging Marker of the Presymptomatic GRN Disease? |
| Q37727937 | Mechanisms of toxicity in C9FTLD/ALS. |
| Q92035807 | Neuroinflammation in frontotemporal dementia |
| Q90364894 | Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency |
| Q47548337 | Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. |
| Q36570798 | Progranulin Reduced Neuronal Cell Death by Activation of Sortilin 1 Signaling Pathways After Subarachnoid Hemorrhage in Rats. |
| Q89698701 | Progranulin: Functions and neurologic correlations |
| Q47623958 | Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease |
| Q34622488 | Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice |
| Q92310096 | Recent advances in understanding frontotemporal degeneration |
| Q38853352 | Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia |
| Q38862587 | Review: Induced pluripotent stem cell models of frontotemporal dementia |
| Q35997814 | SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor. |
| Q59336602 | Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion |
| Q34745270 | Sortilin regulates progranulin action in castration-resistant prostate cancer cells |
| Q38212601 | Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases. |
| Q37457751 | Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin |
| Q53376999 | Targeting microglia for the treatment of Alzheimer's Disease. |
| Q26766372 | The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine |
| Q38661883 | The lysosomal protein cathepsin L is a progranulin protease |
| Q51039924 | The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin |
| Q90627522 | The signal peptide as a new target for drug design |
| Q26998919 | Therapeutic and diagnostic challenges for frontotemporal dementia |
| Q42642970 | Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice |
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