| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2000PNAS...97.3993L |
| P356 | DOI | 10.1073/PNAS.97.8.3993 |
| P932 | PMC publication ID | 18130 |
| P698 | PubMed publication ID | 10760271 |
| P5875 | ResearchGate publication ID | 12556691 |
| P2093 | author name string | R Lu | |
| G Serrero | |||
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| Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) | Q24652242 | ||
| Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo | Q28139070 | ||
| Granulins, a novel class of peptide from leukocytes | Q28268552 | ||
| Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line | Q28269288 | ||
| The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth | Q28274290 | ||
| Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10 | Q29615921 | ||
| The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro. | Q32048245 | ||
| Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII. | Q33488369 | ||
| Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins | Q33838997 | ||
| Growth factors and cancer | Q36441643 | ||
| Molecular insights into breast cancer from transgenic mouse models | Q36457759 | ||
| Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I | Q37033405 | ||
| Insulin-like growth factor expression in human cancer cell lines | Q38357885 | ||
| Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis | Q39444400 | ||
| Transforming growth factors. | Q39464877 | ||
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| Growth factors in breast cancer | Q40928040 | ||
| Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells | Q40969155 | ||
| Apoptosis and angiogenesis: two promising tumor markers in breast cancer (review). | Q41024065 | ||
| Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts | Q41046378 | ||
| The biology of growth regulation in normal and malignant breast epithelium: from bench to clinic | Q41070955 | ||
| Inhibition of estrogen-induced breast cancer cell proliferation by reduction in autocrine transforming growth factor alpha expression | Q41425061 | ||
| Expression of transforming growth factor alpha antisense mRNA inhibits the estrogen-induced production of TGF alpha and estrogen-induced proliferation of estrogen-responsive human breast cancer cells | Q41529961 | ||
| Decreased transforming growth factor-beta response and binding in insulin-independent teratoma-derived cell lines with increased tumorigenic properties | Q41655867 | ||
| Transforming growth factor-alpha expression is enhanced in human mammary epithelial cells transformed by an activated c-Ha-ras protooncogene but not by the c-neu protooncogene, and overexpression of the transforming growth factor-alpha complementary | Q41723967 | ||
| Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor | Q42493841 | ||
| Oncogenic Ha-Ras-dependent mitogen-activated protein kinase activity requires signaling through the epidermal growth factor receptor | Q42825534 | ||
| Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. | Q48365430 | ||
| Isolation and primary structure of the three major forms of granulin-like peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio). | Q52546119 | ||
| Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA. | Q53517464 | ||
| Autocrine secretion and malignant transformation of cells. | Q53575149 | ||
| Isolation and N-Terminal Sequence of Multiple Forms of Granulins in Human Urine | Q62856525 | ||
| Comparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose | Q68132129 | ||
| Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice | Q68462882 | ||
| Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels | Q70222255 | ||
| Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer | Q71059676 | ||
| Biochemical analysis of the epithelin receptor | Q72969354 | ||
| Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features | Q77139593 | ||
| Granulins: the structure and function of an emerging family of growth factors | Q77407040 | ||
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | breast carcinoma | Q18555947 |
| P304 | page(s) | 3993-3998 | |
| P577 | publication date | 2000-04-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. | |
| P478 | volume | 97 |
| Q37275142 | ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor |
| Q26752700 | An update of biochemical markers of hepatocellular carcinoma |
| Q28201181 | Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis |
| Q28569341 | Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation |
| Q37879596 | Cellular effects of progranulin in health and disease |
| Q36244282 | Correlation of granulin expression in intracranial meningiomas to clinical parameters |
| Q37160326 | Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index |
| Q35856777 | Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice |
| Q41149484 | Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin. |
| Q92328533 | Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients |
| Q39782498 | Expression of progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line. |
| Q35870668 | GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation. |
| Q34394760 | GEP, a local growth factor, is critical for odontogenesis and amelogenesis. |
| Q33928138 | GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells |
| Q34115676 | GP88 (progranulin): a novel tissue and circulating biomarker for non-small cell lung carcinoma |
| Q30159662 | Genetic prognostic index influences patient outcome for node-positive breast cancer |
| Q40470271 | Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. |
| Q33868752 | Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis. |
| Q35591909 | Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer. |
| Q33987867 | Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein |
| Q42138301 | Growing a tumor stroma: a role for granulin and the bone marrow |
| Q37676697 | Growth factors as active participants in carcinogenesis: a perspective |
| Q35117713 | Increased Circulating Level of the Survival Factor GP88 (Progranulin) in the Serum of Breast Cancer Patients When Compared to Healthy Subjects |
| Q87825112 | Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis |
| Q33270736 | Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2 |
| Q40779601 | Inhibition of human colon cancer cell growth by antisense oligodeoxynucleotides targeted at basic fibroblast growth factor |
| Q42481718 | Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer. |
| Q34586077 | Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). |
| Q34143246 | Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding |
| Q51973117 | Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. |
| Q43270510 | Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat. |
| Q37175488 | Proepithelin is an autocrine growth factor for bladder cancer |
| Q37150826 | Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. |
| Q89477006 | Prognostic significance of serum progranulin level in de novo adult acute lymphoblastic leukemia patients |
| Q36393198 | Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma |
| Q33187938 | Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development |
| Q35203303 | Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis |
| Q41815313 | Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters |
| Q47425664 | Progranulin and its biological effects in cancer |
| Q34760814 | Progranulin is a chemoattractant for microglia and stimulates their endocytic activity |
| Q40678214 | Progranulin is a mediator of the wound response |
| Q49229992 | Progranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway |
| Q35601050 | Progranulin: a growth factor, a novel TNFR ligand and a drug target |
| Q38138097 | Progranulin: a novel regulator of gastrointestinal cancer progression |
| Q36294670 | Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration |
| Q28254281 | Progranulin: normal function and role in neurodegeneration |
| Q37636855 | Proteoglycans: master modulators of paracrine fibroblast-carcinoma cell interactions |
| Q37730008 | Role of progranulin as a biomarker for Alzheimer's disease |
| Q59618020 | STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment |
| Q38667977 | STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy |
| Q24642763 | Serological identification and expression analysis of gastric cancer-associated genes |
| Q59336602 | Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion |
| Q27650138 | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities |
| Q37892442 | Structure, function, and mechanism of progranulin; the brain and beyond |
| Q37457751 | Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin |
| Q50336657 | The C terminus of sprouty is important for modulation of cellular migration and proliferation |
| Q28642185 | The Evolution of the Secreted Regulatory Protein Progranulin |
| Q38349193 | The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells |
| Q43954815 | The anti-adipogenic effect of PGRN on porcine preadipocytes involves ERK1,2 mediated PPARγ phosphorylation |
| Q42762515 | The application of antisense technology to medicine. |
| Q37358106 | The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases. |
| Q54601832 | The granulin-epithelin precursor is a steroid-regulated growth factor in endometrial cancer. |
| Q24554329 | The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription |
| Q37825835 | The role of ADAMTSs in arthritis |
| Q38922852 | The role of progranulin in arthritis. |
| Q53285285 | Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. |
| Q36073424 | hsDNA groove binding, photocatalytic activity, and in vitro breast and colon cancer cell reducing function of greener SeNPs |
| Q33947283 | miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease |
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