| human | Q5 |
| P496 | ORCID iD | 0000-0003-3118-911X |
| P108 | employer | Ludwig Maximilian University of Munich | Q55044 |
| P735 | given name | Anja | Q16419555 |
| Anja | Q16419555 | ||
| P106 | occupation | researcher | Q1650915 |
| Q40267315 | A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration |
| Q40725025 | A non-amyloidogenic function of BACE-2 in the secretory pathway |
| Q24630100 | ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import |
| Q40763877 | Apical sorting of beta-secretase limits amyloid beta-peptide production |
| Q42825763 | CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk |
| Q59806735 | CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline |
| Q45231223 | Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice |
| Q60912714 | Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology |
| Q58765250 | Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice |
| Q40663039 | Gamma-secretase activity is associated with a conformational change of nicastrin |
| Q28297818 | Gamma-secretase complex assembly within the early secretory pathway |
| Q36013954 | Impaired protein degradation in FTLD and related disorders |
| Q99420895 | Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice |
| Q39767438 | Masking of transmembrane-based retention signals controls ER export of gamma-secretase |
| Q26824221 | Mechanisms of granulin deficiency: lessons from cellular and animal models |
| Q36003800 | Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration |
| Q51973117 | Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. |
| Q47903554 | Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain |
| Q40619177 | Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain |
| Q64889283 | Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. |
| Q41889633 | Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane |
| Q34030951 | Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production |
| Q28201180 | Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide |
| Q34170826 | Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression |
| Q39838808 | Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin |
| Q35904539 | Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin |
| Q39320638 | Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells |
| Q58125066 | Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation |
| Q36366427 | TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. |
| Q36073450 | TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance |
| Q24314869 | The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes |
| Q40619751 | The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity |
| Q48177216 | The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects |
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