Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases

scientific article published on 30 August 2011

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MOLMED.2011.07.005
P932PMC publication ID3225699
P698PubMed publication ID21885342
P5875ResearchGate publication ID51613519

P50authorChristian M HedrichQ50271955
P2093author name stringGeorge C Tsokos
P2860cites workMicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteinsQ83586463
Hypomethylation of LINE-1 but not Alu in lymphocyte subsets of systemic lupus erythematosus patientsQ83876356
MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosusQ84505308
Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylationQ84569794
The Microprocessor complex mediates the genesis of microRNAsQ24312976
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3BQ24564757
MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancerQ24643430
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytesQ24651802
MicroRNAs modulate hematopoietic lineage differentiationQ27860661
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNAQ27860813
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timingQ27860903
Processing of primary microRNAs by the Microprocessor complexQ27860986
Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosusQ56894263
Genetic deficiency of C4, C2 or C1q and lupus syndromes. Association with anti-Ro (SS-A) antibodiesQ69877518
Development of Autoantibodies before the Clinical Onset of Systemic Lupus ErythematosusQ79171865
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblastsQ79795007
Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupusQ81386368
Expression signature of microRNA-181-a reveals its crucial role in the pathogenesis of paediatric systemic lupus erythematosusQ83563765
MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complexQ28143627
DNA methylation regulates MicroRNA expressionQ28238278
Cracking the enigmatic linker histone codeQ28266573
miR-181a is an intrinsic modulator of T cell sensitivity and selectionQ28294631
The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activityQ28510260
Regulation of mRNA translation and stability by microRNAsQ29547304
Genetic mapping in human diseaseQ29614943
MicroRNA control in the immune system: basic principlesQ29618112
MiR-150 controls B cell differentiation by targeting the transcription factor c-MybQ29619411
Repression of protein synthesis by miRNAs: how many mechanisms?Q29620361
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosusQ33618909
Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosusQ33889455
A blast from the past: clearance of apoptotic cells regulates immune responses.Q34162195
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylatedQ34624154
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritisQ34766857
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.Q34837305
The epigenetics of autoimmunityQ34979322
Recent insights into the genetic basis of systemic lupus erythematosusQ34980873
X inactivation and the complexities of silencing a sex chromosomeQ34983583
Genetics and pathogenesis of multiple sclerosisQ35004746
Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.Q35048475
Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosusQ35143592
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurelyQ35758613
Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onsetQ35765504
The TNFalpha locus is altered in monocytes from patients with systemic lupus erythematosusQ35867539
Revealing the world of RNA interferenceQ35889563
A methylation rendezvous: reader meets writersQ36837766
MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjögren's syndromeQ36841784
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylationQ37065897
DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.Q37068711
microRNAs and the immune responseQ37178538
Transcriptional regulation of IL-2 in health and autoimmunityQ37250679
Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4(+)CD28(-) T cellsQ37261179
MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.Q37262433
Stimulatory and inhibitory killer Ig-like receptor molecules are expressed and functional on lupus T cellsQ37314445
Epigenetic control of T-helper-cell differentiationQ37371624
A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humansQ37452331
Epigenetic control in rheumatoid arthritis synovial fibroblasts.Q37468471
Epigenetic histone code and autoimmunityQ37575071
Rheumatic diseases: environment and geneticsQ37635553
Epigenetics and autoimmunityQ37669513
Cell type-specific regulation of IL-10 expression in inflammation and diseaseQ37678256
The role of defective clearance of apoptotic cells in systemic autoimmunity.Q37739807
Interleukin-17-producing T cells in lupusQ37769076
Rheumatoid arthritis progression mediated by activated synovial fibroblastsQ37782498
Updating on the pathogenesis of systemic lupus erythematosusQ37791687
Is there a link between dysregulated miRNA expression and disease?Q37793417
Epigenetics in lupusQ37830732
Epigenetics and autoimmunity, with special emphasis on methylationQ37860845
miR-449a targets HDAC-1 and induces growth arrest in prostate cancerQ39878284
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupusQ40144366
Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patientsQ40229057
The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cellsQ40308810
Rapid alteration of microRNA levels by histone deacetylase inhibitionQ40322140
Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes.Q41177636
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.Q41412954
Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activityQ41959555
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tailQ41965881
B cells contribute to ischemia/reperfusion-mediated tissue injuryQ42539245
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expressionQ42640386
DNA hypomethylation in rheumatoid arthritis synovial fibroblasts.Q43233238
Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: a new mechanism for TCR zeta chain deficiency and abnormal signalingQ43968077
Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosusQ44062277
Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expressionQ45099932
IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylationQ46043693
Epigenetics and microRNAsQ46057707
Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugsQ46477434
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.Q46483776
HLA DRB1*1503 allelic haplotype predominance and associated immunodysregulation in systemic lupus erythematosusQ46681395
Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complexQ46806709
Demethylation of CD40LG on the inactive X in T cells from women with lupusQ46942094
Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositisQ47793786
Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosusQ47849248
Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cellsQ47991791
Prevalence of ZAP-70, LAT, SLP-76, and DNA methyltransferase 1 expression in CD4+ T cells of patients with systemic lupus erythematosus.Q50684216
Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice.Q51602846
MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.Q54374935
Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells.Q54443042
Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis.Q54517861
Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus.Q54551006
Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells.Q54615805
P433issue12
P921main subjectlupus erythematosusQ188297
systemic lupus erythematosusQ1485
P304page(s)714-724
P577publication date2011-08-30
P1433published inTrends in Molecular MedicineQ15265842
P1476titleEpigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases
P478volume17

Reverse relations

cites work (P2860)
Q34464114Advances in lupus genetics and epigenetics
Q92380687B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids
Q92735504BCL-6 suppresses miR-142-3p/5p expression in SLE CD4+ T cells by modulating histone methylation and acetylation of the miR-142 promoter
Q35171894Biomarker profiling for lupus nephritis
Q37726675CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance
Q41712674DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding
Q88841098DNA methylation in systemic lupus erythematosus
Q39184388DNA methylation of human endogenous retrovirus in systemic lupus erythematosus
Q61959801Depressive Disorders: Prevalence, Costs, and Theories
Q48238048Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.
Q34344835Environmental influences on systemic lupus erythematosus expression
Q39142245Epigenetic Alterations in Cellular Immunity: New Insights into Autoimmune Diseases
Q92243141Epigenetic Priming in Immunodeficiencies
Q38694852Epigenetic alterations underlying autoimmune diseases
Q38152825Epigenetic dysregulation in systemic lupus erythematosus
Q39456337Epigenetic involvement in etiopathogenesis and implications in treatment of systemic lupus erythematous
Q38206864Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells
Q38553346Epigenetics and Systemic Lupus Erythematosus: Unmet Needs
Q38650522Epigenetics in SLE.
Q26772330Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response
Q37097751Epigenetics of the antibody response
Q90319414Estradiol regulates the expression of CD45 splicing isoforms in lymphocytes
Q91712007Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a
Q36612326Ethnic differences in DNA methyltransferases expression in patients with systemic lupus erythematosus
Q92889821Expression Profiling and Clinical Significance of Plasma MicroRNAs in Diabetic Nephropathy
Q38111622Gene-function studies in systemic lupus erythematosus.
Q64071574Genome-Wide DNA Methylation Profiles Reveal Common Epigenetic Patterns of Interferon-Related Genes in Multiple Autoimmune Diseases
Q37089523High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot
Q34647217Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses
Q36236807Immunogenetics of systemic lupus erythematosus: A comprehensive review
Q37581443MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples
Q28943338Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians
Q34549827MicroRNAs in lupus
Q47972361Natural antisense RNAs are involved in the regulation of CD45 expression in autoimmune diseases
Q90683634Peripheral nerve injury and myelination: Potential therapeutic strategies
Q38091122Perspectives on epigenetic-based immune intervention for rheumatic diseases
Q58710822Precision DNA demethylation ameliorates disease in lupus-prone mice
Q36150047Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells
Q37168446Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling
Q37350170Sex differences in the expression of lupus-associated miRNAs in splenocytes from lupus-prone NZB/WF1 mice
Q27010090Small molecules in the treatment of systemic lupus erythematosus
Q34217935Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling
Q37602111Targeted DNA methylation analysis by high throughput sequencing in porcine peri-attachment embryos
Q64102294The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review
Q90705230The Pathogenic Role of Dysregulated Epigenetic Modifications in Autoimmune Diseases
Q92106859The Role of Epigenetics in Autoimmune/Inflammatory Disease
Q35986953The Upregulation of Genomic Imprinted DLK1-Dio3 miRNAs in Murine Lupus Is Associated with Global DNA Hypomethylation
Q38085206The applied basic research of systemic lupus erythematosus based on the biological omics.
Q37048453The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway
Q35723616The real culprit in systemic lupus erythematosus: abnormal epigenetic regulation
Q28389137The role of epigenetic mechanisms and processes in autoimmune disorders
Q92309432Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo
Q41228881Translating epigenetics into clinic: focus on lupus
Q38193368Unmet needs in autoimmunity and potential new tools
Q36339914cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
Q37511786cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells
Q37477836cAMP responsive element modulator: a critical regulator of cytokine production
Q36466592cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).
Q35763036cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).
Q36977367miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1

Search more.