The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review

scholarly article by Qiancheng Deng et al published 2019 in Frontiers in Immunology

The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2019.00856
P932PMC publication ID6482221
P698PubMed publication ID31057561

P2093author name stringChristopher Chang
Rong Xiao
Yan Ding
Haijing Wu
Yangyang Luo
Qiancheng Deng
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Effector and memory CD8+ T cell fate coupled by T-bet and eomesoderminQ34465675
CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancerQ34585720
Rapamycin-sensitive signals control TCR/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylationQ34628368
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The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiationQ34712267
Cytokines and the inception of CD8 T cell responsesQ34783475
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B).Q34784615
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunityQ34876814
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Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.Q34979730
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MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.Q35023511
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Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo.Q39302905
miR-625-3p is upregulated in CD8+ T cells during early immune reconstitution after allogeneic stem cell transplantationQ40064947
Differential gene induction by type I and type II interferons and their combinationQ40262695
Identification of the IFITM family as a new molecular marker in human colorectal tumorsQ40314375
Rapid alteration of microRNA levels by histone deacetylase inhibitionQ40322140
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing.Q40325436
The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and HomeostasisQ40414812
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patientsQ40656580
Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced NeuroinflammationQ40775503
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Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.Q41590208
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IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environmentQ41845687
Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activityQ41959555
Global DNA methylation remodeling accompanies CD8 T cell effector function.Q42275830
The effects of CD40- and interleukin (IL-4)-activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves' disease: the role of CD8+ cellsQ42520842
IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosusQ42625867
DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feedingQ44026024
Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosusQ44062277
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosusQ45217503
Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family.Q45956433
Epigenetics and microRNAsQ46057707
Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosusQ46925835
Review: Metabolic Control of Immune System Activation in Rheumatic DiseasesQ47133379
Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of interferon-associated genes in CD4+ and CD8+ T cellsQ47178838
MicroRNA-140 suppresses osteosarcoma tumor growth by enhancing anti-tumor immune response and blocking mTOR signalingQ47369820
Survival of autoreactive T lymphocytes by microRNA-mediated regulation of apoptosis through TRAIL and Fas in type 1 diabetes.Q47611305
The impact of cellular metabolism on chromatin dynamics and epigeneticsQ47617054
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.Q47765824
Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cellsQ47991791
Epigenetic Networks Regulate the Transcriptional Program in Memory and Terminally Differentiated CD8+ T Cells.Q48154175
Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells.Q49246137
microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases.Q50460948
Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors.Q50533942
CRYAB modulates the activation of CD4+ T cells from relapsing-remitting multiple sclerosis patients.Q50937116
Abnormal histone acetylation of CD8+ T cells in patients with severe aplastic anemia.Q51598382
Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients.Q51799957
Differentiation of human CD8(+) T cells from a memory to memory/effector phenotype.Q52012681
Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.Q52022962
Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial.Q52650139
CD8 T cells and mTOR: new concepts and targets for systemic lupus erythematosus.Q52650140
CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia.Q54200652
Abnormalities of quantities and functions of linker for activations of T cells in severe aplastic anemia.Q54364478
Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape.Q54944228
Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8 T and NK Cells in Heart Transplant PatientsQ57491427
Metabolic Signaling into Chromatin Modifications in the Regulation of Gene ExpressionQ60950072
Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosisQ62748342
S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosineQ71364484
Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditisQ83280554
CpG island methylation pattern in different human tissues and its correlation with gene expressionQ83642628
CD8+ T cells in systemic sclerosisQ84474506
Advances on CD8+ Treg Cells and Their Potential in TransplantationQ88456088
Metabolism as a Target for Modulation in Autoimmune DiseasesQ88607770
Crosstalk between metabolism and epigenetic modifications in autoimmune diseases: a comprehensive overviewQ89424601
Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney InjuryQ90727203
Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.Q37280990
Metabolism and epigenetics.Q37388258
Genetic disruption of CD8+ Treg activity enhances the immune response to viral infectionQ37421220
Epigenetic therapeutics in autoimmune diseaseQ37567572
Epigenetic histone code and autoimmunityQ37575071
Pathogenic CD8(+) T cells in multiple sclerosisQ37594690
Epigenetics and autoimmunityQ37669513
Dysregulated miR34a/diacylglycerol kinase ζ interaction enhances T-cell activation in acquired aplastic anemiaQ37701557
Diabetes mellitus, a microRNA-related disease?Q37855088
Epigenetics and autoimmunity, with special emphasis on methylationQ37860845
CD8(+) T cells: foot soldiers of the immune systemQ37922333
FOXP3+ regulatory T cells: from suppression of rejection to induction of renal allograft toleranceQ37937127
Etiology of autoimmune disease: past, present and futureQ37979837
Potential roles for CD8(+) T cells in rheumatoid arthritis.Q38030281
Epigenetics in autoimmune diseases with focus on type 1 diabetesQ38062497
The critical importance of epigenetics in autoimmunityQ38078660
Promotion and prevention of autoimmune disease by CD8+ T cellsQ38122896
Calorie restriction and NAD⁺/sirtuin counteract the hallmarks of agingQ38217569
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.Q35027765
The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cureQ35103993
miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)Q35139405
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosisQ35143918
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in miceQ35486021
Epigenetic control of interferon-gamma expression in CD8 T cells.Q35564148
Methylation and demethylation in the regulation of genes, cells, and responses in the immune systemQ35571270
Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseasesQ35577576
SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in MiceQ35588961
Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2.Q35609669
Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndromeQ35732790
The role of epigenetic variation in the pathogenesis of systemic lupus erythematosusQ35840786
Epigenetics and autoimmune diseases.Q35867015
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.Q36008100
Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairmentQ36085104
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon MetabolismQ36253836
Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patientsQ36255464
Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve?Q36257320
Scleroderma: from cell and molecular mechanisms to disease modelsQ36259889
miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cellsQ36262472
Cytotoxic T lymphocytes and autoimmunityQ36285811
CD8+ T cells in autoimmunityQ36286977
MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T CellsQ36291335
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulationQ36390497
Lupus autoimmunity altered by cellular methylation metabolismQ36527588
Inflaming the CD8+ T cell response.Q36543883
The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteineQ36731236
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental ChangesQ36969070
miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA.Q37087212
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181aQ37145975
microRNAs and the immune responseQ37178538
Autoimmune mechanisms in type 1 diabetesQ37215820
MicroRNAs: new regulators of immune cell development and functionQ37223449
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectsystematic reviewQ1504425
histone modificationQ14911658
MirnasQ16464788
P304page(s)856
P577publication date2019-01-01
P1433published inFrontiers in ImmunologyQ27723748
P1476titleThe Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review
P478volume10

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cites work (P2860)
Q96304897The contribution of epigenetics to the pathogenesis and gender dimorphism of systemic sclerosis: a comprehensive overview
Q98567727Transcription and DNA Methylation patterns of blood derived CD8+ T cells are associated with age and Inflammatory Bowel Disease but do not predict prognosis
Q92309432Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo

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