Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis

scientific article published on 18 March 2015

Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1021246P
P356DOI10.1371/JOURNAL.PONE.0121246
P932PMC publication ID4364993
P698PubMed publication ID25785991
P5875ResearchGate publication ID273784114

P50authorJuan C OsorioQ43176323
Chun Geun LeeQ56810022
Augustine M K ChoiQ114342087
P2093author name stringJack A Elias
Ying Shi
Danielle Morse
Ivan O Rosas
Jin Woo Song
Souheil El-Chemaly
Kenji Mizumura
Sarah G Chu
Avignat S Patel
P2860cites workMitochondria in cell deathQ50550781
Insufficient autophagy in idiopathic pulmonary fibrosis.Q53138134
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanismsQ84762346
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagyQ84788113
Proteasomes in lungs from organ donors and patients with end-stage pulmonary diseasesQ95558988
Autophagy in idiopathic pulmonary fibrosisQ21134133
PINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingQ24297960
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionQ24320327
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsQ24322788
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silicaQ24649598
Selective degradation of mitochondria by mitophagyQ24658163
Mechanisms of mitophagyQ27310261
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegenerationQ27348827
Oxidative stress and glutathione in TGF-beta-mediated fibrogenesisQ28393454
p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemiaQ28509575
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient miceQ28513036
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineQ29547303
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseasesQ29615646
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinQ29615684
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyQ29616005
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancerQ29616379
Oxidative phosphorylation at the fin de siècleQ33538525
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activationQ34635121
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.Q35056685
A key role for NOX4 in epithelial cell death during development of lung fibrosis.Q35185363
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.Q35728305
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase ParkinQ35783335
Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neuronsQ35855944
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitmentQ35874914
Evolving concepts of apoptosis in idiopathic pulmonary fibrosisQ36493966
Mitochondrial alterations in Alzheimer's diseaseQ36549402
The interplay between mitochondrial dynamics and mitophagyQ37815475
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stressQ40262236
TGF beta1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells.Q40462552
Asbestos-derived reactive oxygen species activate TGF-beta1.Q40560323
Mitochondrial reactive oxygen species regulate transforming growth factor-β signalingQ41921136
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpulmonary fibrosisQ32446
P304page(s)e0121246
P577publication date2015-03-18
P1433published inPLOS OneQ564954
P1476titleEpithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis
P478volume10

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