Differential expression of sirtuins in the aging rat brain

scientific article published on 8 May 2015

Differential expression of sirtuins in the aging rat brain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FNCEL.2015.00167
P932PMC publication ID4424846
P698PubMed publication ID26005404
P5875ResearchGate publication ID276443247

P50authorPerminder SachdevQ7169326
Gilles J. GuilleminQ38329804
Tailoi Chan-LingQ54918180
Hussein MansourQ58185470
Anne PoljakQ60672465
Nady BraidyQ62016536
P2093author name stringGeorge Smythe
Ross Grant
Tharusha Jayasena
P2860cites workThe human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylaseQ24296836
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycleQ24299947
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cellsQ24301843
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseQ24310456
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradationQ24322745
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)Q24338668
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcriptionQ24546024
SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle CellsQ24633565
miR-34a repression of SIRT1 regulates apoptosisQ24652720
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanQ28203572
Mechanism of human SIRT1 activation by resveratrolQ28238262
Conserved metabolic regulatory functions of sirtuinsQ28267340
Oxidative stress in neurodegeneration: cause or consequence?Q28275946
Small molecules that regulate lifespan: evidence for xenohormesisQ28276642
Mitochondria and neurodegenerationQ80184491
Vitamins and aging: pathways to NAD+ synthesisQ80272192
Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosisQ81470372
Aging-related changes in oxidative stress response of human endothelial cellsQ87041767
SIR2: a potential target for calorie restriction mimeticsQ28282154
NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicityQ28476267
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferaseQ28505800
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6Q28509079
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged ratsQ28564619
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of ratsQ28569951
Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulinQ28572741
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activityQ28573891
Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availabilityQ28577932
Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activityQ28582534
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylationQ28586153
Proteolipid protein is required for transport of sirtuin 2 into CNS myelinQ28587657
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycleQ28592294
Sirtuins in mammals: insights into their biological functionQ29615248
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degenerationQ29616075
Extrachromosomal rDNA circles--a cause of aging in yeastQ29618308
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytesQ29619456
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasisQ29620243
Human Sir2 and the 'silencing' of p53 activityQ30309900
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesityQ30497676
The Sir 2 family of protein deacetylasesQ33222287
Validation of reference genes for quantitative RT-PCR studies of gene expression in perennial ryegrass (Lolium perenne L.)Q33525408
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar ratsQ33889428
NAD+ metabolism in health and diseaseQ34001412
Mitochondria, oxidative damage, and inflammation in Parkinson's diseaseQ34212155
Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolusQ34214625
The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extensionQ34389466
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restrictionQ34534198
Mitochondrial involvement in amyotrophic lateral sclerosisQ34535144
Therapeutic potential of sirtuin-activating compounds in Alzheimer's diseaseQ34653129
Differential expression of sirtuin family members in the developing, adult, and aged rat brain.Q34730013
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.Q34852226
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.Q35698011
Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neuronsQ35762698
Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).Q36188541
Neuronal protection by sirtuins in Alzheimer's diseaseQ36283826
Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysisQ36472868
The biochemistry of sirtuins.Q36498332
Sirtuins in aging and age-related disease.Q36549075
SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiologyQ36659976
A stress response pathway involving sirtuins, forkheads and 14-3-3 proteinsQ36685722
SIRT1 and neuronal diseasesQ36775876
Sirtuins: the 'magnificent seven', function, metabolism and longevityQ36911415
Divergence of biological and chronological aging: evidence from rodent studiesQ36962116
Brain SIRT1: anatomical distribution and regulation by energy availabilityQ36962837
Modulation of sirtuins: new targets for antiageing.Q37067530
The Sirtuin family: therapeutic targets to treat diseases of agingQ37087540
Frontiers of model animals for neuroscience: two prosperous aging model animals for promoting neuroscience researchQ38156519
Role of antioxidant enzymes in cell immortalization and transformationQ39564949
Direct, real-time monitoring of superoxide generation in isolated mitochondria.Q39831808
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motilityQ40003738
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.Q40351435
Aging, energy, and oxidative stress in neurodegenerative diseases.Q40478731
Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosisQ40723426
An assay for superoxide dismutase activity in mammalian tissue homogenatesQ45026389
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signalingQ46218230
Exercise training promotes SIRT1 activity in aged rats.Q46857793
Resveratrol mimics ischemic preconditioning in the brainQ46881136
Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with agingQ46916981
Mitochondrial membrane potential supported by exogenous cytochrome c oxidation mimics the early stages of apoptosisQ48018662
Single-cell analysis of mtDNA in amyotrophic lateral sclerosis: towards the characterization of individual neurons in neurodegenerative disordersQ48224531
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insultsQ48347278
Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated miceQ48482724
Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation.Q48600704
Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cellsQ48856939
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.Q53237533
Sirtuins Caught in the ActQ62779695
How old is old?Q69617957
Glial, vascular, and neuronal cytogenesis in whole-mounted cat retinaQ73069067
P4510describes a project that usesImageJQ1659584
P304page(s)167
P577publication date2015-05-08
P1433published inFrontiers in Cellular NeuroscienceQ2131509
P1476titleDifferential expression of sirtuins in the aging rat brain
P478volume9

Reverse relations

cites work (P2860)
Q57929129A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets
Q90163732Advances of Molecular Markers and Their Application for Body Variables and Carcass Traits in Qinchuan Cattle
Q37352729Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System.
Q93051136Emerging Role of Sirtuin 2 in Parkinson's Disease
Q39401700Emerging Roles of Sirtuins in Ischemic Stroke.
Q92535831Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders
Q89414984Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway
Q46237953Expression of Sirtuins in the Retinal Neurons of Mice, Rats, and Humans
Q38768258Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status.
Q33774831Is SIRT6 Activity Neuroprotective and How Does It Differ from SIRT1 in This Regard?
Q55177681Mitochondria, Estrogen and Female Brain Aging.
Q58784374Molecular Imaging of Sirtuin1 Expression-Activity in Rat Brain Using Positron-Emission Tomography-Magnetic-Resonance Imaging with [F]-2-Fluorobenzoylaminohexanoicanilide
Q92751113Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels
Q34554358Neuroprotective Functions for the Histone Deacetylase SIRT6
Q89968291Noninvasive quantification of SIRT1 expression-activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[18F]BzAHA PET/CT/MRI
Q38880656Nutritional strategies to optimise cognitive function in the aging brain.
Q51436509PEP-1-SIRT2-induced matrix metalloproteinase-1 and -13 modulates type II collagen expression via ERK signaling in rabbit articular chondrocytes.
Q59798260Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
Q37533588Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat.
Q90575070Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
Q38579945Sirt6 regulates dendritic cell differentiation, maturation, and function
Q37549018Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation
Q37710177Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
Q36118417Stem cell aging in adult progeria.
Q57799627The Plasma NAD Metabolome Is Dysregulated in "Normal" Aging
Q39313687The brain, sirtuins, and ageing

Search more.