Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy

scientific article published on 9 May 2015

Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1047878340
P356DOI10.1186/S12885-015-1397-4
P932PMC publication ID4435808
P698PubMed publication ID25956431
P5875ResearchGate publication ID276066344

P50authorBeata Bode-LesniewskaQ88127558
P2093author name stringBruno Fuchs
Bernhard Robl
Sander Martijn Botter
Chantal Pauli
P2860cites workA new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
Maspin polymorphism associated with apoptosis susceptibility and in vivo tumorigenesis.Q39951217
VEGF expression as a prognostic marker in osteosarcomaQ39961610
Effect of chemotherapy on the mutation frequency of ovarian cancer cells at the HPRT locus.Q40374170
Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behaviorQ40534589
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasisQ40602468
Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation.Q41973810
Analysis of prognostic factors in 333 Chinese patients with high-grade osteosarcoma treated by multidisciplinary combined therapyQ44826148
Prognostic significance of p53 expression in malignant bone tumors: a meta-analysisQ46477265
P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapyQ46477473
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.Q48230264
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.Q48334505
Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas.Q48584099
Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma.Q52619511
Expression change of ezrin as a prognostic factor in primary osteosarcoma.Q54410065
Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.Q54653964
Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cellsQ24336533
Maspin is not required for embryonic development or tumour suppressionQ24612315
Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancerQ27824834
p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.Q27851827
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locusQ29619815
The Prognostic Role of Ezrin Immunoexpression in Osteosarcoma: A Meta-Analysis of Published DataQ30651861
Tissue microarray (TMA) technology: miniaturized pathology archives for high-throughput in situ studiesQ30724668
Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcomaQ30999677
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results ProgramQ33406382
Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysisQ33531554
Twenty years of p53 research: structural and functional aspects of the p53 proteinQ33807787
Expression of mutant p53 protein in hepatocellular carcinomaQ34378463
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.Q34413741
Prognostic impact of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomasQ34447850
Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.Q34532932
Osteosarcoma (osteogenic sarcoma).Q34574274
Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2.Q34611314
CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patientsQ35764430
Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progressionQ35791446
Survival from high-grade localised extremity osteosarcoma: combined results and prognostic factors from three European Osteosarcoma Intergroup randomised controlled trials.Q35988850
Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferationQ36115896
Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancerQ36117164
Prognostic value of nuclear maspin expression for adjuvant 5-fluorouracil-based chemotherapy in advanced gastric cancerQ36224775
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumorsQ36486421
An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomyQ36610246
The prognostic significance of CD44V6, CDH11, and β-catenin expression in patients with osteosarcomaQ37067646
Cyclooxygenase-2 overexpression predicts poor survival in patients with high-grade extremity osteosarcoma: a pilot studyQ37380171
Ki67 in breast cancer: prognostic and predictive potentialQ37691691
Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcomaQ37794441
A meta-analysis of osteosarcoma outcomes in the modern medical eraQ38006949
Mutational analysis of p53 in human tumors: immunocytochemistryQ38451777
Maspin influences response to doxorubicin by changing the tumor microenvironment organization.Q39062271
The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapyQ39733218
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effortQ39793825
p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours.Q54672464
Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 AccumulationQ57274851
Neoadjuvante Therapie des lokalisierten Osteosarkoms der ExtremitätenQ57339782
Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbsQ57339791
Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomasQ57966210
Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ59586373
Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of TumorsQ60050244
A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcomaQ61848887
p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistryQ63446378
Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variablesQ69426532
[Determination of the degree of morphological regression following chemotherapy in malignant bone tumors]Q70909544
Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children's Cancer GroupQ71975310
Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosisQ73483291
Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosisQ74099329
PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapyQ74715361
Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocolsQ77579162
Pre- and post-chemotherapy alkaline phosphatase levels as prognostic indicators in adults with localised osteosarcomaQ81453409
Prognostic factors for teenage and adult patients with high-grade osteosarcoma: an analysis of 240 patientsQ86922680
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectchemotherapyQ974135
P304page(s)379
P577publication date2015-05-09
P1433published inBMC CancerQ326300
P1476titlePrognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy
P478volume15

Reverse relations

cites work (P2860)
Q501328812-Methoxyestradiol Reverses the Pro-Carcinogenic Effect of L-Lactate in Osteosarcoma 143B Cells
Q52847679Cytologic anaplasia is a prognostic factor in osteosarcoma biopsies, but mitotic rate or extent of spontaneous tumor necrosis are not: a critique of the College of American Pathologists Bone Biopsy template.
Q89622492Differential Outcomes and Biologic Markers of Radiation-Associated vs. Sporadic Osteosarcoma: A Single-Institution Experience
Q90338870Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma
Q50947610Molecular markers of DNA damage and repair in cervical cancer patients treated with cisplatin neoadjuvant chemotherapy: an exploratory study.
Q35826810Neoadjuvant chemotherapy (NCT) plus targeted agents versus NCT alone in colorectal liver metastases patients: A systematic review and meta-analysis
Q40633762Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance
Q55312849Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.
Q38685591P16 protein expression as a useful predictive biomarker for neoadjuvant chemotherapy response in patients with high-grade osteosarcoma: A systematic meta-analysis under guideline of PRISMA.
Q90616566PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1
Q96431810Promising abscopal effect of combination therapy with thermal tumour ablation and intratumoural OK-432 injection in the rat osteosarcoma model
Q92137525Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
Q38754899p16 protein expression and correlation with clinical and pathological features in osteosarcoma of the jaws: Experience of 37 cases.

Search more.