Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA

scientific article published on August 1999

Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1999PNAS...9610489B
P356DOI10.1073/PNAS.96.18.10489
P8608Fatcat IDrelease_siroen6itzakvaaqee6uuodimy
P932PMC publication ID17916
P698PubMed publication ID10468636
P5875ResearchGate publication ID12830657

P2093author name stringA C Sartorelli
D A Johnson
S Rockwell
W F Hodnick
D H Sherman
P G Penketh
M F Belcourt
P2860cites workIsolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activityQ24612623
The scanning model for translation: an updateQ24679648
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivityQ28293841
Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cellsQ28323572
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductaseQ33630320
Mitomycin, a new antibiotic from Streptomyces. I.Q34538266
A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDSQ36399158
Fluorometric assay for the determination of DNA-DNA cross-links utilizing Hoechst 33258 at neutral pH valuesQ36885403
Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulaeQ39932763
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.Q40450112
Mitomycin C: a prototype bioreductive agent.Q40450118
Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphoraseQ41004810
Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.Q41461028
Therapeutic attack of hypoxic cells of solid tumors: presidential addressQ46171952
MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.Q55037555
Inducible synthesis of the mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae.Q55066771
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNAQ70329806
Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphoraseQ71210020
Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugsQ72855186
Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cellsQ72892841
Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin CQ73879835
The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cellsQ74424554
CROSSLINKING OF DNA BY ENZYMATICALLY OR CHEMICALLY ACTIVATED MITOMYCINS AND PORFIROMYCINS, BIFUNCTIONALLY "ALKYLATING" ANTIBIOTICSQ76959585
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)10489-10494
P577publication date1999-08-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA
P478volume96

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cites work (P2860)
Q35718407Bioactivation and resistance to mitomycin C.
Q46046775Chapter 2. From microbial products to novel drugs that target a multitude of disease indications
Q39737530Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism
Q37192362Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity.
Q43678680Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone
Q37396793Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches
Q27639365Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein
Q35215703Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism

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