The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

scientific article published on January 2006

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044009729
P356DOI10.1186/AR2099
P932PMC publication ID1794533
P698PubMed publication ID17177994
P5875ResearchGate publication ID6622188

P50authorJan BondesonQ455303
Clare E. HughesQ46565033
P2093author name stringSarah Lauder
Shane D Wainwright
Nick Amos
P2860cites workPurification and cloning of aggrecanase-1: a member of the ADAMTS family of proteinsQ22009926
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Usefulness of high resolution US in the evaluation of effusion in osteoarthritic first carpometacarpal jointQ74011868
Development of anti-TNF therapy for rheumatoid arthritisQ74187188
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradationQ74419209
C-reactive protein as a biomarker of emergent osteoarthritisQ78649895
Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced proteinQ78794868
Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severityQ81412996
Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter studyQ81922681
Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.Q30836366
Catabolism of aggrecan, decorin and biglycan in tendon.Q30894356
Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled studyQ32067927
An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patientsQ33244618
Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritisQ33565984
Design and synthetic considerations of matrix metalloproteinase inhibitorsQ33692904
Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implicationsQ33692920
Cytokines and their role in the pathophysiology of osteoarthritisQ33753628
Degradative enzymes in osteoarthritis.Q33753639
The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal modelsQ33894450
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targetsQ34283578
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritisQ34407611
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitroQ34407615
Anticytokine therapy for osteoarthritisQ34452635
The role of cytokines in osteoarthritis pathophysiologyQ34524517
Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the kneeQ35548883
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis.Q35549401
Synovial macrophage-osteoclast differentiation in inflammatory arthritisQ35551058
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependentQ36172262
Lessons learned from nine clinical trials of disease-modifying osteoarthritis drugsQ36301297
Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediatorsQ36364193
Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?Q40684838
Cytokine inducible matrix metalloproteinase expression in immortalized rat chondrocytes is independent of nitric oxide stimulationQ41031027
Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockadeQ42956113
Synovial tissue inflammation in early and late osteoarthritisQ43048512
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritisQ43873302
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritisQ44064388
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitroQ44183277
Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formationQ44733622
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritisQ44985215
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout miceQ45034879
Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues.Q48049317
Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.Q50735189
Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependentQ57539923
Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston county osteoarthritis projectQ57721652
Inflammation and angiogenesis in osteoarthritisQ59151152
High resolution ultrasonography in detection of bone erosions in patients with hand osteoarthritisQ59536393
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapyQ60169453
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P433issue6
P921main subjectosteoarthritisQ62736
macrophageQ184204
P304page(s)R187
P577publication date2006-01-01
P1433published inArthritis Research and TherapyQ15757229
P1476titleThe role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis
P478volume8

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