| scholarly article | Q13442814 |
| retracted paper | Q45182324 |
| P50 | author | John L. Harwood | Q42114441 |
| Bruce Caterson | Q42663796 | ||
| Clare E. Hughes | Q46565033 | ||
| Christopher B Little | Q58048957 | ||
| Sarah Rees | Q91553722 | ||
| Ivan G Otterness | Q114445677 | ||
| Carl R Flannery | Q114445678 | ||
| Colin M Dent | Q114445679 | ||
| P2093 | author name string | Chris Wilson | |
| Clare L Curtis | |||
| P2860 | cites work | Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins | Q22009926 |
| Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family | Q22010479 | ||
| The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain | Q24293718 | ||
| Characterization of the human 5-lipoxygenase gene promoter | Q24556586 | ||
| ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix | Q28137781 | ||
| ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan | Q28142856 | ||
| Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 | Q28207975 | ||
| Cyclooxygenases 1 and 2 | Q29615645 | ||
| n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation | Q30642447 | ||
| Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro. | Q30807179 | ||
| Catabolism of aggrecan, decorin and biglycan in tendon. | Q30894356 | ||
| Polyunsaturated fatty acids and rheumatoid arthritis | Q32064084 | ||
| Expression and activity of ADAMTS-5 in synovium | Q32081150 | ||
| Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate | Q33710597 | ||
| Regulation of gene expression by dietary fat. | Q33711759 | ||
| Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene | Q33938511 | ||
| Polyunsaturated fatty acid regulation of gene expression | Q34322482 | ||
| Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells | Q36313374 | ||
| Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. | Q37365072 | ||
| Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage | Q37365557 | ||
| Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases | Q40860401 | ||
| Pro- and anti-inflammatory cytokines in rheumatoid arthritis | Q40861531 | ||
| Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid. | Q41145304 | ||
| Mechanism of catabolism of aggrecan by articular cartilage | Q41850195 | ||
| Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes | Q41866734 | ||
| N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage | Q42682254 | ||
| Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro | Q42822923 | ||
| 15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways. | Q43678254 | ||
| Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function | Q44769598 | ||
| Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase | Q47772495 | ||
| Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues. | Q48049317 | ||
| Influence of interleukin-1 on the morphology and proteoglycan metabolism of cultured bovine articular chondrocytes. | Q50796625 | ||
| Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. | Q50907649 | ||
| Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage | Q57539960 | ||
| Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis | Q71408249 | ||
| Arachidonate 5-lipoxygenase | Q71456757 | ||
| Current indications for single digit replantation | Q71856835 | ||
| Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody | Q73073300 | ||
| Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1) | Q73574480 | ||
| Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes | Q73661487 | ||
| Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis | Q73812383 | ||
| The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation | Q74419209 | ||
| Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity | Q74485183 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | fatty acid | Q61476 |
| osteoarthritis | Q62736 | ||
| inflammation | Q101991 | ||
| cartilage | Q502730 | ||
| P304 | page(s) | 1544-1553 | |
| P577 | publication date | 2002-06-01 | |
| P1433 | published in | Arthritis and Rheumatism | Q23929027 |
| P1476 | title | Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids | |
| P478 | volume | 46 |
| Q36084925 | A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee |
| Q39171637 | A prospective, randomized, double blind, placebo-controlled evaluation of the effects of eicosapentaenoic acid and docosahexaenoic acid on the clinical signs and erythrocyte membrane polyunsaturated fatty acid concentrations in dogs with osteoarthri |
| Q37952849 | A whole-person model of care for persistent pain: from conceptual framework to practical application |
| Q36393546 | ADAMTS proteinases: potential therapeutic targets? |
| Q81725933 | ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo |
| Q60461829 | ADAMTS-4 and ADAMTS-5 |
| Q34205901 | ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis |
| Q91307883 | ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease |
| Q83008511 | Activation of the peroxisome proliferator-activated receptor alpha pathway potentiates interleukin-1 receptor antagonist production in cytokine-treated chondrocytes |
| Q37357912 | Advances in nutritional research on regulatory T-cells |
| Q37354336 | Aggrecanase and aggrecan degradation in osteoarthritis: a review |
| Q24804310 | Aggrecanases and cartilage matrix degradation |
| Q28570613 | Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes |
| Q40600622 | Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes |
| Q36122829 | An introduction to dietary/supplemental omega-3 fatty acids for general health and prevention: part II. |
| Q44860128 | Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema |
| Q50964115 | Autologous chondrocyte implantation (ACI) for aged patients: development of the proper cell expansion conditions for possible therapeutic applications. |
| Q35666160 | Biological basis for the benefit of nutraceutical supplementation in arthritis |
| Q91251770 | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| Q37779575 | Bone marrow lesions in the knee: the clinical conundrum |
| Q33216010 | Catabolism of aggrecan proteoglycan aggregate components in short-term explant cultures of tendon |
| Q42473985 | Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. |
| Q44888963 | Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acids. |
| Q37071562 | Deficiency of G-protein coupled receptor 40, a lipid-activated receptor, heightens in vitro- and in vivo-induced murine osteoarthritis |
| Q36272337 | Diet and rheumatoid arthritis: a review of the literature |
| Q36975133 | Dietary Lipid During Late-Pregnancy and Early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs |
| Q45140653 | Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production |
| Q37270750 | Dietary fatty acid intake affects the risk of developing bone marrow lesions in healthy middle-aged adults without clinical knee osteoarthritis: a prospective cohort study |
| Q35150616 | Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritis |
| Q33221781 | Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats |
| Q57265719 | Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis |
| Q51786952 | Effect of fish oil on bone mineral density in aging C57BL/6 female mice. |
| Q35147261 | Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids |
| Q47946604 | Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro |
| Q37596829 | Fat and fatty acid terminology, methods of analysis and fat digestion and metabolism: a background review paper |
| Q54275610 | Fat as a physiological regulator: the news gets better. |
| Q80389608 | Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease |
| Q41383716 | Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose |
| Q37827227 | Fish oil in rheumatic diseases |
| Q91752491 | Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model |
| Q85796304 | Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis |
| Q58816430 | High dietary fat and the development of osteoarthritis in a rabbit model |
| Q57744511 | Imaging of knee osteoarthritis |
| Q30873765 | Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon |
| Q35621083 | Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. |
| Q56058540 | In vitro effects of eicosanoids derived from different 20-carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole-blood cultures |
| Q84914238 | Intra-articular lentivirus-mediated insertion of the fat-1 gene ameliorates osteoarthritis |
| Q35067439 | Lipids and the immune response: from molecular mechanisms to clinical applications |
| Q35109730 | Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients |
| Q36944640 | Long-chain n-3 fatty acids in lipid rafts: implications for anti-inflammatory effects |
| Q57359837 | Long-term n-3 polyunsaturated fatty acids administration ameliorates arteriosclerosis by modulating T-cell activity in a rat model of small intestine transplantation |
| Q38981772 | Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5. |
| Q40627969 | Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
| Q35056019 | Metalloproteinases: their role in arthritis and potential as therapeutic targets |
| Q35150608 | Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism |
| Q35742522 | N-3 polyunsaturated fatty acids and allergic disease. |
| Q35171527 | N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. |
| Q34444693 | Natural anti-inflammatory agents for pain relief |
| Q34582570 | Natural antiinflammatory agents for pain relief in athletes |
| Q28248812 | New parenteral lipid emulsions for clinical use |
| Q36209436 | Nutraceutical therapies for degenerative joint diseases: a critical review. |
| Q34146992 | Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products |
| Q26860861 | Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis |
| Q36645068 | Nutrition and osteoarthritis in dogs: does it help? |
| Q36099812 | Nutrition for aging cats and dogs and the importance of body condition |
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| Q38013279 | Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients |
| Q24649574 | Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis |
| Q21195656 | Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence |
| Q38065129 | Osteoarthritis: what does imaging tell us about its etiology? |
| Q52996671 | Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid. |
| Q36260682 | Pathogenesis of degenerative temporomandibular joint arthritides |
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| Q51576370 | Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-κB. |
| Q36078649 | Polyunsaturated fatty acids and inflammation |
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| Q48187380 | Polyunsaturated fatty acids influence inflammatory markers in a cellular model for canine osteoarthritis. |
| Q38073087 | Postconcussion syndrome: a review of pathophysiology and potential nonpharmacological approaches to treatment |
| Q93118970 | Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages |
| Q33220315 | Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats |
| Q36063705 | Retractions in orthopaedic research: A systematic review |
| Q37827230 | Role of diet in rheumatic disease. |
| Q35933890 | Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health |
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| Q33188443 | Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling |
| Q43254785 | Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials |
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| Q37081004 | The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise |
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| Q46940517 | The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators |
| Q37825835 | The role of ADAMTSs in arthritis |
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| Q34532557 | The role of fish oils in the treatment of rheumatoid arthritis |
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