Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids

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Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2011/969012
P932PMC publication ID3150191
P698PubMed publication ID21826146
P5875ResearchGate publication ID51556534

P2093author name stringJörg Jerosch
P2860cites workOsteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidenceQ21195656
Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trialQ39871697
Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent mannerQ40106311
Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cellsQ40133543
Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive geneQ41833959
Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis.Q42541481
Synovial tissue inflammation in early and late osteoarthritisQ43048512
Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritisQ43276199
Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysisQ43546528
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritisQ43873300
The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary studyQ44097220
Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteersQ44163866
Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytesQ44394411
Glucosamine and chondroitin sulfate: biological response modifiers of chondrocytes under simulated conditions of joint stressQ44439622
The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explantsQ45711565
Fibronectin fragments mediate matrix metalloproteinase upregulation and cartilage damage through proline rich tyrosine kinase 2, c-src, NF-kappaB and protein kinase Cdelta.Q46028651
Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt.Q46106596
Modification of the composition of articular cartilage collagen fibrils with increasing age.Q46259243
Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trialQ46321177
The complex pathology of osteoarthritis: even mitochondria are involvedQ46453970
Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explantsQ46480686
Effect of glucosamine sulfate on hip osteoarthritis: a randomized trialQ46746770
Differing results of trials of glucosamine for pain in arthritis: comment on the article by VLAD et al.Q46830088
Marginal efficacy of glucosamine: comment on the article by VLAD et al and the editorial by ReginsterQ46830098
Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogsQ47209677
Chronic stress tolerance levels for human articular cartilage: two nonuniform contact models applied to long-term follow-up of CDH.Q48541282
Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot studyQ48592216
Glucosamine prevents in vitro collagen degradation in chondrocytes by inhibiting advanced lipoxidation reactions and protein oxidationQ22000860
Glucosamine therapy for treating osteoarthritisQ24244026
The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trialQ24630475
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE systemQ24647595
EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)Q24674132
Obesity and osteoarthritis: more complex than predicted!Q24675065
Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte functionQ24804197
Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritisQ24805523
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1Q24816719
Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 productionQ28115730
Matrix metalloproteinasesQ28140451
Free radicals, antioxidants, and nutritionQ28205310
Collagen Synthesis in tenocytes, ligament cells and chondrocytes exposed to a combination of Glucosamine HCl and chondroitin sulfateQ28212371
Do glucosamine and chondroitin treat the symptoms of osteoarthritis?Q28354361
Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysisQ28374250
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritisQ28943498
A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfortQ29394573
Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.Q30836366
Prevalence and correlates of osteoarthritis in Germany. Representative data from the First National Health SurveyQ30990480
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trialQ32050561
Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytesQ32067938
Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placeboQ33199633
Osteoarthritis: a metabolic disease induced by local abnormal leptin activity?Q33212755
Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trialsQ33214439
Clinical review of chondroitin sulfate in osteoarthritisQ33357124
Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review.Q33366624
Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explantsQ33368886
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysisQ33422129
Evaluation of the effect of antiarthritic drugs on the secretion of proteoglycans by lapine chondrocytes using a novel assay procedureQ33561663
Effects of fish oil supplementation in rheumatoid arthritisQ33562342
Genetics of osteoarthritisQ33579265
Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate.Q50478261
Metabolic and ultrastructural changes in articular cartilage of rats fed dietary supplements of omega-3 fatty acids.Q50879603
Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis?Q51033276
Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression.Q51161871
24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain.Q51706290
A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis.Q55033577
The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest.Q55044134
Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolismQ56169415
Sex and ethnic differences in the association ofASPN,CALM1,COL2A1,COMP, andFRZB with genetic susceptibility to osteoarthritis of the kneeQ57445849
Cod liver oil (n-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritisQ61830864
Metabolic fate of exogenous chondroitin sulfate in the experimental animalQ67294092
Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in cultureQ67754603
Failure of selenium-ace to improve osteoarthritisQ68519878
Fish-oil fatty acid supplementation in active rheumatoid arthritis. A double-blinded, controlled, crossover studyQ70168695
The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford StudyQ70661807
Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 productionQ73348681
Inflammation is a feature of the disease process in early knee joint osteoarthritisQ73574859
The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2Q74279990
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytesQ74430431
Quantitative structural organization of normal adult human articular cartilageQ74486244
Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13Q74714921
ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation statusQ77105435
Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphateQ78444082
Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritisQ79345643
Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritisQ79467035
Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradationQ79872147
Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritisQ80707124
Chondrocyte senescence, joint loading and osteoarthritisQ80851787
OsteoarthritisQ81042522
Glucosamine therapy for osteoarthritis: an updateQ81042715
Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trialQ81484755
Knee structural alteration and BMI: a cross-sectional studyQ81596030
Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytesQ82607594
The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulfateQ95305820
The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combinationQ33679221
NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragmentsQ33992822
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritisQ33993736
Dietary supplements for osteoarthritis.Q34009777
Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysisQ34214244
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targetsQ34283578
Risk factors for osteoarthritis: geneticsQ34286731
Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant dosesQ34383021
Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritisQ34510491
N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytesQ34514554
Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathwayQ34520479
Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind studyQ34528067
Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytesQ34534426
The role of reactive oxygen species in homeostasis and degradation of cartilageQ34537354
Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studiesQ34546341
Risk assessment for glucosamine and chondroitin sulfateQ34570456
Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparatorQ34574562
Current role of glucosamine in the treatment of osteoarthritis.Q34578263
Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials.Q34581685
Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22(Phox) and iNOS expression.Q34586059
Glucosamine for pain in osteoarthritis: why do trial results differ?Q34643259
Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritisQ34656760
Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamineQ34752761
GlucosamineQ34816926
Review article: GlucosamineQ34978110
Nutritional management of rheumatoid arthritis: a review of the evidenceQ35093729
Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam StudyQ35638607
The effect of nutritional supplements on osteoarthritisQ35896687
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic interventionQ36171836
Aggrecan, aging and assembly in articular cartilage.Q36249555
Matrix metalloproteinases: role in arthritisQ36251020
The effects of exercise on human articular cartilageQ36459463
Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trialQ36464778
Genetic influences on osteoarthritis in women: a twin studyQ36598099
Cellular, molecular, and matrix changes in cartilage during aging and osteoarthritisQ36691025
Low-selenium diet, bone, and articular cartilage in rats.Q36698619
Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritisQ36736328
Osteoarthritis: aging of matrix and cells--going for a remedyQ36737794
TGF-beta and osteoarthritisQ36773157
Osteoarthritis in 2007.Q36964888
Obesity and osteoarthritis: disease genesis and nonpharmacologic weight managementQ37001372
Adipokines as emerging mediators of immune response and inflammation.Q37014112
ADAMTS-5: the story so far.Q37076199
Cartilage in normal and osteoarthritis conditionsQ37154103
Potential effects of chondroitin sulfate on joint swelling: a GAIT reportQ37167150
Developments in the clinical understanding of osteoarthritisQ37207005
Articular cartilage: structure, injuries and review of managementQ37234022
Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalanceQ37267822
Osteoarthritis: a tale of three tissues.Q37304243
Immunomodulatory and anti-inflammatory effects of chondroitin sulphateQ37310621
Obesity and the musculoskeletal systemQ37354006
Glucosamine and chondroitin for osteoarthritisQ37354339
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases.Q37400435
Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic reviewQ37427642
A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation.Q37497607
The effects of oral glucosamine on joint health: is a change in research approach needed?Q37592565
Obesity and inflammation--targets for OA therapy.Q37701900
The effects of contact pressure elevations and aseptic necrosis on the long-term outcome of congenital hip dislocation.Q38095759
Human articular chondrocytes express functional leptin receptorsQ38297153
Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolismQ38303866
Evidence for a key role of leptin in osteoarthritisQ38348145
Cartilage contact pressure elevations in dysplastic hips: a chronic overload modelQ39103446
Sulfated glycosaminoglycans and glucosamine may synergize in promoting synovial hyaluronic acid synthesisQ39429209
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectfatty acidQ61476
glucosamineQ32907954
P304page(s)969012
P577publication date2011-08-02
P1433published inInternational journal of rheumatologyQ26853833
P1476titleEffects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids
P478volume2011