Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes

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Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes is …
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scholarly articleQ13442814

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P356DOI10.1016/S1063-4584(03)00052-9
P698PubMed publication ID12801482

P2093author name stringS A Jimenez
G R Dodge
P2860cites workStructure of the human aggrecan gene: exon-intron organization and association with the protein domainsQ24528200
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Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysisQ28374250
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Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritisQ31938498
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trialQ32050561
Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytesQ32067938
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncationQ34109859
A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the kneeQ34122293
Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro.Q34503637
Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitroQ34508733
Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfates in articular cartilage explantsQ34515154
Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathwayQ34520479
Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamineQ34752761
Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C.Q38296491
Glucosamine HCl reduces equine articular cartilage degradation in explant cultureQ42490895
Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activationQ43935477
A simple, rapid, and sensitive DNA assay procedureQ56879279
Formation of nodular structures resembling mature articular cartilage in long–term primary cultures of human fetal epiphyseal chondrocytes on a hydrogel substrateQ61771891
In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfateQ73322078
Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilageQ73367599
Characterization of human type II procollagen and collagen-specific antibodies and their application to the study of human type II collagen processing and ultrastructureQ73410885
Effects of interleukin-1beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytesQ73887889
Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cellsQ74034155
Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acidQ77967633
P433issue6
P921main subjectosteoarthritisQ62736
glucosamineQ32907954
P304page(s)424-432
P577publication date2003-06-01
P1433published inOsteoarthritis and CartilageQ7107605
P1476titleGlucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
P478volume11

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