Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis

scientific article

Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis is …
instance of (P31):
meta-analysisQ815382
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1001/JAMA.283.11.1469
P8608Fatcat IDrelease_wy5pwi6nqnfcnban2p2yzm6afi
P3181OpenCitations bibliographic resource ID663211
P698PubMed publication ID10732937

P2093author name stringD T Felson
T E McAlindon
M P LaValley
J P Gulin
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectglucosamineQ32907954
osteoarthritisQ62736
meta-analysisQ815382
P304page(s)1469-75
P577publication date2000-03-15
P1433published inThe Journal of the American Medical AssociationQ1470970
P1476titleGlucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis
P478volume283

Reverse relations

cites work (P2860)
Q35128655???Natural Remedies??? in the Treatment of Osteoarthritis
Q92155858A Double-Blind, Randomized Controlled 12-Week Follow-Up Trial to Evaluate the Efficacy and Safety of Polycan in Combination with Glucosamine for the Treatment of Knee Osteoarthritis
Q36955387A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee
Q36075955A hierarchy of patient-reported outcomes for meta-analysis of knee osteoarthritis trials: empirical evidence from a survey of high impact journals
Q36301591A longitudinal study of nonvitamin, nonmineral supplement use: prevalence, associations, and survival in an aging population
Q35770645A randomized comparative study of safety and efficacy of immediate release glucosamine HCL and glucosamine HCL sustained release formulation in the treatment of knee osteoarthritis: A proof of concept study
Q34122293A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee
Q35007384A review of articular cartilage pathology and the use of glucosamine sulfate
Q44302980A survey of self-medication practices and perceived effectiveness of glucosamine products among older adults
Q46602405Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial
Q35072852Advances in rheumatology: coxibs and beyond
Q79218992American Association of Clinical Endocrinologists Medical Guidelines for the Clinical Use of Dietary Supplements and Nutraceuticals
Q24633869An empirical investigation of the potential impact of selective inclusion of results in systematic reviews of interventions: study protocol
Q36306651An overview of hip injuries in running
Q90548301Anserine and glucosamine supplementation attenuates the levels of inflammatory markers in rats with rheumatoid arthritis
Q51421445Anti-arthritic effect of GN1, a novel synthetic analog of glucosamine, in the collagen-induced arthritis model in rats.
Q34977910Articular Cartilage Injury in Athletes
Q43525281Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model
Q44638466Biochemical injection treatment for discogenic low back pain: a pilot study
Q35666160Biological basis for the benefit of nutraceutical supplementation in arthritis
Q24202794Bisphosphonates for osteoarthritis
Q34545778Carbohydrate engineered cells for regenerative medicine.
Q36245717Characterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
Q34655436Chondroitin and glucosamine in the management of osteoarthritis: an update
Q22000858Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study
Q24186473Chondroitin for osteoarthritis
Q24245297Chondroitin for osteoarthritis
Q34002078Chondroitin sulfate in the management of hip and knee osteoarthritis: an overview
Q36059429Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations.
Q35042879Chondroitin sulphate inhibits connective tissue mast cells
Q34906145Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI
Q35196931Chondroprotective agents: glucosamine and chondroitin
Q34280879Chronic non-malignant musculoskeletal pain in older adults: clinical issues and opioid intervention
Q28212371Collagen Synthesis in tenocytes, ligament cells and chondrocytes exposed to a combination of Glucosamine HCl and chondroitin sulfate
Q36475626Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Q46367849Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model.
Q36675924Comparative efficacy and safety study of two chondroitin sulfate preparations from different origin (avian and bovine) in symptomatic osteoarthritis of the knee
Q82234503Compare the effects of chondrogenesis by culture of human mesenchymal stem cells with various type of the chondroitin sulfate C
Q21254655Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]
Q33632751Comparison of glucose derivatives effects on cartilage degradation
Q84649749Complementary and Alternative Medicines: Clinical Pearls for Commonly Used Dietary Supplements
Q34235511Complementary and alternative therapies for rheumatic disease
Q30356453Complementary or alternative therapies for osteoarthritis.
Q35824619Conducting clinical trials over the internet: feasibility study.
Q36067679Considerations in the treatment of early osteoarthritis
Q59481265Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
Q37706220D-Glucosamine supplementation extends life span of nematodes and of ageing mice
Q38856377DRUG THERAPY IN KNEE OSTEOARTHROSIS.
Q24653945Determination of chondroitin sulfate content in raw materials and dietary supplements by high-performance liquid chromatography with ultraviolet detection after enzymatic hydrolysis: single-laboratory validation
Q33920880Dietary supplements as disease-modifying treatments in osteoarthritis: a critical appraisal
Q34536820Dietary supplements for football.
Q30235140Differentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment
Q39767735Digital X-ray radiogrammetry better identifies osteoarthritis patients with a low bone mineral density than quantitative ultrasound
Q38371965Discrepancies in composition and biological effects of different formulations of chondroitin sulfate.
Q36055502Disease-modifying therapies for osteoarthritis : current status
Q34572300Do shrimp-allergic individuals tolerate shrimp-derived glucosamine?
Q41982421Dual Function of Glucosamine in Gelatin/Hyaluronic Acid Cryogel to Modulate Scaffold Mechanical Properties and to Maintain Chondrogenic Phenotype for Cartilage Tissue Engineering
Q24674132EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)
Q31119321EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).
Q84448818Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: a randomized, double-blind, placebo-controlled pilot study using MRI
Q44602669Effect of Brand's glucosamine with essence of chicken on collagen-induced arthritis in rats
Q35676918Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials
Q36230822Effect of a glucosamine-based combination supplement containing chondroitin sulfate and antioxidant micronutrients in subjects with symptomatic knee osteoarthritis: A pilot study
Q73558500Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot study
Q44533873Effect of chondroitin sulphate C on the in vitro and in vivo chondrogenesis of mesenchymal stem cells in crosslinked type II collagen scaffolds
Q34001775Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled study
Q33313591Effect of combined laser acupuncture on knee osteoarthritis: a pilot study
Q40526468Effect of glucosamine on intraocular pressure: a randomized clinical trial.
Q35627520Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial
Q37398414Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study
Q35147261Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids
Q78032713Effects of a milk-based bioactive micronutrient beverage on pain symptoms and activity of adults with osteoarthritis: a double-blind, placebo-controlled clinical evaluation
Q90178117Effects of dietary supplements on selected hematological and biochemical parameters of Pakistani athletes
Q54493171Effects of glucosamine administration on patients with rheumatoid arthritis.
Q35125975Effects of glucosamine and chondroitin supplementation on knee osteoarthritis: an analysis with marginal structural models
Q88528202Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis
Q24606203Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis
Q44525457Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage
Q43804474Effects of oral glucosamine and chondroitin sulfate alone and in combination on the metabolism of SHR and SD rats
Q34345032Efficacies of different preparations of glucosamine for the treatment of osteoarthritis: a meta-analysis of randomised, double-blind, placebo-controlled trials
Q36517447Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study
Q92416265Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials
Q34605351Efficacy of glucosamine, chondroitin, and methylsulfonylmethane for spinal degenerative joint disease and degenerative disc disease: a systematic review
Q33943890Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study
Q44660320Enzymatic Synthesis of Chondroitin and Its Derivatives Catalyzed by Hyaluronidase
Q24647595Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system
Q37204153Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: A randomized double-blind placebo-controlled clinical study
Q36409280Evaluation of the effect of methionine and glucosamine on adjuvant arthritis in rats
Q33847208Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double-blind placebo-controlled clinical study
Q46770338Evidence-based evaluation of study results of symptomatic glucosamine therapy
Q36603277Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis
Q35056506FGF-FGFR signaling mediated through glycosaminoglycans in microtiter plate and cell-based microarray platforms
Q28215692GLUT2 is a high affinity glucosamine transporter
Q79319417Glucosamine and chondroitin for osteoarthritis: to recommend or not to recommend?
Q42330053Glucosamine and chondroitin for the treatment of osteoarthritis
Q28360122Glucosamine and chondroitin may help in osteoarthritis
Q34656760Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis
Q57244851Glucosamine and chondroitin sulfate in knee osteoarthritis: where now?
Q24805719Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: biochemical rationale and case report
Q43090795Glucosamine binding to proteins in plasma and synovial fluid and blood cell/plasma partitioning in mouse and man in vitro.
Q41176136Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro
Q21284705Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism
Q28366848Glucosamine for osteoarthritis: magic, hype, or confusion? It's probably safe-but there's no good evidence that it works
Q33214439Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials
Q34534426Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
Q24244026Glucosamine therapy for treating osteoarthritis
Q50057188Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort
Q37036372Glucosamine-containing supplement improves locomotor functions in subjects with knee pain - a pilot study of gait analysis
Q36244219Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study
Q55498592Glucosamine: A potential disease-modifying agent in osteoarthritis?
Q36918156Glucosamine: an ingredient with skin and other benefits
Q32050548Glusoamine for osteoarthritis: dawn of a new era?
Q54995051Glycosaminoglycans and Proteoglycans.
Q34576349Herbal and nonherbal supplements in medical-psychiatric patient populations
Q34974685Hip pain and mobility deficits--hip osteoarthritis: clinical practice guidelines linked to the international classification of functioning, disability, and health from the orthopaedic section of the American Physical Therapy Association.
Q58040371Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study
Q33994668Immunological activity of chondroitin sulfate
Q44102095Immunosuppressive effects of glucosamine
Q43090797In vitro study of the inhibition and induction of human cytochromes P450 by crystalline glucosamine sulfate.
Q47816389Inappropriate claims from non-equivalent medications in osteoarthritis: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
Q44832606Influence of irrigation solutions combined with colchicine and diclofenac sodium on articular cartilage in a rat model
Q33815355Integrative approaches to pain management: how to get the best of both worlds
Q40626602Interleukin-12 release from macrophages by hyaluronan, chondroitin sulfate A and chondroitin sulfate C oligosaccharides
Q37062477Intervertebral disc: anatomy-physiology-pathophysiology-treatment
Q97527844Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis
Q21195259Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?
Q81382549Is treatment with chondroitin efficacious for osteoarthritis?
Q31046250Long-Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six-Year Followup Data From the Osteoarthritis Initiative
Q32050561Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial
Q35636751Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness
Q42496279Managing osteoarthritis of the knee
Q35871489Mast cells and mast cell mediators as targets of dietary supplements
Q24799604Meta-analysis: neither quick nor easy
Q43108976Method for Delivering a Controlled Impact to Articular Cartilage in the Rabbit Knee
Q34303993Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?
Q32066343New agents for the medical treatment of interstitial cystitis
Q46106832Non-surgical treatment of osteoarthritis of large joints - new aspects
Q35553761Non-surgical treatment of osteoarthritis: a half century of "advances".
Q36209436Nutraceutical therapies for degenerative joint diseases: a critical review.
Q37020227Nutrition for throwers, jumpers, and combined events athletes
Q34686551Nutritional genomics
Q36981763Nutritional supplements and conventional medicine; what should the physician know?
Q56032350Osteoarthritis
Q36085680Osteoarthritis - an untreatable disease?
Q21195656Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence
Q30863651Osteoarthritis of the knee
Q34976432Osteoarthritis: supplements and other alternative modalities
Q35740878PURLs: arthritis pain? These supplements provide little relief.
Q44778759Pharmacological interaction of glucosamine sulphate and acenocoumarol
Q33631650Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes
Q34112904Pharmacoproteomic study of three different chondroitin sulfate compounds on intracellular and extracellular human chondrocyte proteomes
Q93025858Predictive factors of adherence to an association of glucosamine sulfate, copper, and ginger extracts in patients with symptomatic osteoarthritis: a prospective open-label French noninterventional study (the PREDOA study)
Q36768159Predictors of symptomatic response to glucosamine in knee osteoarthritis: an exploratory study
Q59083206Preparation and characterisation of vanadium complexes derived from salicylaldehyde or pyridoxal and sugar derivatives
Q38856700Prevalence of Glucosamine and Omega-3 Fatty Acid Use and Characteristics of Users among Mid-Age Women: Analysis of a Nationally Representative Sample of 10,638 Women
Q58912917Primer documento de consenso de la Sociedad Española de Reumatología sobre el tratamiento farmacológico de la artrosis de rodilla
Q35000443Prospective image registration for automated scan prescription of follow-up knee images in quantitative studies
Q37611121Quality of different chondroitin sulfate preparations in relation to their therapeutic activity
Q34630468Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis
Q33802220Recent advances: rheumatology
Q33802329Regular review: medical management of osteoarthritis
Q33803779Research into complementary and alternative medicine: problems and potential
Q37868846Review article: Osteochondral reconstruction and grafting.
Q34098905Rheumatology and musculoskeletal medicine
Q34570456Risk assessment for glucosamine and chondroitin sulfate
Q34423402Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials.
Q34264613Role of glucosamine in the treatment for osteoarthritis
Q47147618Scientific Opinion on the substantiation of a health claim related to glucosamine hydrochloride and reduced rate of cartilage degeneration and reduced risk of development of osteoarthritis pursuant to Article 14 of Regulation (EC) No 1924/2006
Q42135777Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties
Q53567904Sensitive and rapid analytical method for the quantification of glucosamine in human plasma by ultra high performance liquid chromatography with tandem mass spectrometry.
Q36406090Short report: ibuprofen versus glucosamine sulfate. Treating osteoarthritis pain
Q51652992Sixty percent of patients with rheumatoid arthritis in Japan have used dietary supplements or health foods.
Q34003218Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort
Q36067671State-of-the-art disease-modifying osteoarthritis drugs
Q36527599Supplements and injections for joint disease
Q39044794Suppressive effects of D-glucosamine on the 5-HT sensitive nociceptive units in the rat tooth pulpal nerve
Q34789324Sweet solution: sugars to the rescue
Q64923946Symptoms-modifying effects of electromotive administration of glucosamine sulphate among patients with knee osteoarthritis.
Q34402862Synergy between medical and nutrient therapies: George Washington meets Rodney Dangerfield
Q37992137Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis
Q37596611Targeting subchondral bone for treating osteoarthritis: what is the evidence?
Q37603698Temporomandibular joint osteoarthritis: diagnosis and long-term conservative management: a topic review
Q33622337The Hip and Knee Book: developing an active management booklet for hip and knee osteoarthritis
Q24630475The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial
Q24799688The effect of glucosamine sulphate on osteoarthritis: design of a long-term randomised clinical trial [ISRCTN54513166].
Q37933356The effect on comorbidity and pain in patients with osteoarthritis
Q37667284The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled trial
Q36765477The horse as a model of naturally occurring osteoarthritis
Q34729786The placebo effect and randomized trials: analysis of alternative medicine
Q37049693The post-NSAID era: what to use now for the pharmacologic treatment of pain and inflammation in osteoarthritis
Q37154872The post-NSAID era: what to use now for the pharmacologic treatment of pain and inflammation in osteoarthritis
Q37228620The potential of chondroitin sulfate as a therapeutic agent
Q59797962The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis: a network meta-analysis of randomised controlled trials
Q36719696The reverse glucosamine sulfate pathway: application in knee osteoarthritis
Q37020249The use of dietary supplements by athletes
Q45127723The use of glucosamine therapy in osteoarthritis
Q35624596The use of glucosamine therapy in osteoarthritis
Q36793235The utility of nutraceuticals in the treatment of osteoarthritis
Q82328978Therapy for osteoarthritis in the horse - how do we know that it works?
Q46905515Thermal and storage stability of nutraceuticals in a milk beverage dietary supplement
Q33849348Total mortality risk in relation to use of less-common dietary supplements
Q43709029Transcriptional engineering of Escherichia coli K4 for fructosylated chondroitin production
Q54193159Transdermal Permeability of N-Acetyl-D-Glucosamine
Q37762660Treatment of glenohumeral arthrosis.
Q36713906Treatment of knee osteoarthritis with oral chondroitin sulfate
Q37858371Treatment options for osteoarthritis: considerations for older adults
Q33323179Update in pain medicine
Q34473924Use of complementary and alternative medicine in pediatric pain management service: a survey
Q35554070Use of complementary medicines for osteoarthritis--a prospective study
Q35220305Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort
Q36900371Use of glucosamine and chondroitin supplements and risk of colorectal cancer.
Q39644887Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals follow-up study
Q91867823Use of glucosamine and chondroitin to treat osteoarthritis: a review of the literature
Q24657307Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States
Q64933398Variability in the prescription of drugs with uncertain effectiveness. The case of SYSADOA in the Basque Country.
Q44650052Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
Q34439681What a difference a year makes: reflections on the ACR recommendations for the medical management of osteoarthritis
Q35578049What is important in treating osteoarthritis? Whom should we treat and how should we treat them?
Q31080416Who uses glucosamine and why? A study of 266,848 Australians aged 45 years and older
Q35578069Why are clinical trials of glucosamine no longer uniformly positive?
Q84600034[Current therapeutic approach osteoarthritis]
Q88336488[Pharmacological treatment of osteoarthritis-related pain]
Q53448367[The management of osteoarthritis by general practitioners in Germany: comparison of self-reported behaviour with international guidelines].

Search more.