Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function

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Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1044963061
P356DOI10.1186/AR1499
P3181OpenCitations bibliographic resource ID1559072
P932PMC publication ID1065334
P698PubMed publication ID15743486
P5875ResearchGate publication ID7991503

P2093author name stringKusuki Nishioka
Hiroshi Nakamura
Tomohiro Kato
Kazuo Yudoh
Kayo Hongo-Masuko
van Trieu Nguyen
P2860cites workSpecific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Oxidants, oxidative stress and the biology of ageingQ28131725
Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survivalQ28363133
Telomeres shorten during ageing of human fibroblastsQ29547357
Oxidative stress shortens telomeresQ29615533
Telomere length predicts replicative capacity of human fibroblastsQ29615745
Structure and function of telomeresQ29615759
Nitric oxide in osteoarthritisQ33695642
Telomere reduction in human colorectal carcinoma and with ageingQ34037761
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytesQ34106524
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotypeQ34233470
Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritisQ34507684
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expressionQ34770083
Roles of chondrocytes in the pathogenesis of osteoarthritisQ34793658
Deleterious mitochondrial DNA mutations accumulate in aging human tissuesQ35340913
Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degenerationQ35768757
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginineQ36510258
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic dataQ36564192
Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolismQ38354914
Measurement of pH and ionic composition of pericellular sitesQ40335395
Human diploid fibroblasts display a decreased level of c-fos mRNA at 72 hours after exposure to sublethal H2O2 stressQ40866185
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.Q40926739
Growth of human embryonic fibroblasts at clonal density: Concordance with results from mass culturesQ41565737
Telomere erosion and senescence in human articular cartilage chondrocytes.Q43562778
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen speciesQ43882919
Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilageQ43959855
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.Q44159746
Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathwayQ44163870
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: Interaction with exogenous cytokinesQ44441107
Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitriteQ50336019
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue.Q50907649
Telomere length as a marker of oxidative stress in primary human fibroblast culturesQ59313972
Replicative aging of human articular chondrocytes during ex vivo expansionQ59348652
Release of oxygen radicals by articular chondrocytes: A study of luminol‐dependent chemiluminescence and hydrogen peroxide secretionQ67465102
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharideQ68261503
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurinationQ71584102
Prevalence of degenerative morphological changes in the joints of the lower extremityQ73018468
Decreased cellular activity and replicative capacity of osteoblastic cells isolated from the periarticular bone of rheumatoid arthritis patients compared with osteoarthritis patientsQ73092704
The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritisQ73393601
Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteinsQ73900827
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 levelQ73904644
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stressQ77332057
Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitriteQ77567629
Matrix homeostasis in aging normal human ankle cartilageQ78505454
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectosteoarthritisQ62736
oxidative stressQ898814
cartilageQ502730
P304page(s)R380-91
P577publication date2005-01-26
P1433published inArthritis Research and TherapyQ15757229
P1476titlePotential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
P478volume7

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