scholarly article | Q13442814 |
P2093 | author name string | Kusuki Nishioka | |
Hiroshi Nakamura | |||
Tomohiro Kato | |||
Kazuo Yudoh | |||
Kayo Hongo-Masuko | |||
van Trieu Nguyen | |||
P2860 | cites work | Specific Association of Human Telomerase Activity with Immortal Cells and Cancer | Q27860801 |
Oxidants, oxidative stress and the biology of ageing | Q28131725 | ||
Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival | Q28363133 | ||
Telomeres shorten during ageing of human fibroblasts | Q29547357 | ||
Oxidative stress shortens telomeres | Q29615533 | ||
Telomere length predicts replicative capacity of human fibroblasts | Q29615745 | ||
Structure and function of telomeres | Q29615759 | ||
Nitric oxide in osteoarthritis | Q33695642 | ||
Telomere reduction in human colorectal carcinoma and with ageing | Q34037761 | ||
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes | Q34106524 | ||
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype | Q34233470 | ||
Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis | Q34507684 | ||
Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression | Q34770083 | ||
Roles of chondrocytes in the pathogenesis of osteoarthritis | Q34793658 | ||
Deleterious mitochondrial DNA mutations accumulate in aging human tissues | Q35340913 | ||
Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration | Q35768757 | ||
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine | Q36510258 | ||
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data | Q36564192 | ||
Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism | Q38354914 | ||
Measurement of pH and ionic composition of pericellular sites | Q40335395 | ||
Human diploid fibroblasts display a decreased level of c-fos mRNA at 72 hours after exposure to sublethal H2O2 stress | Q40866185 | ||
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. | Q40926739 | ||
Growth of human embryonic fibroblasts at clonal density: Concordance with results from mass cultures | Q41565737 | ||
Telomere erosion and senescence in human articular cartilage chondrocytes. | Q43562778 | ||
Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species | Q43882919 | ||
Influence of hypoxia and reoxygenation on cytokine-induced production of proinflammatory mediators in articular cartilage | Q43959855 | ||
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1. | Q44159746 | ||
Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway | Q44163870 | ||
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: Interaction with exogenous cytokines | Q44441107 | ||
Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite | Q50336019 | ||
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. | Q50907649 | ||
Telomere length as a marker of oxidative stress in primary human fibroblast cultures | Q59313972 | ||
Replicative aging of human articular chondrocytes during ex vivo expansion | Q59348652 | ||
Release of oxygen radicals by articular chondrocytes: A study of luminol‐dependent chemiluminescence and hydrogen peroxide secretion | Q67465102 | ||
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide | Q68261503 | ||
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination | Q71584102 | ||
Prevalence of degenerative morphological changes in the joints of the lower extremity | Q73018468 | ||
Decreased cellular activity and replicative capacity of osteoblastic cells isolated from the periarticular bone of rheumatoid arthritis patients compared with osteoarthritis patients | Q73092704 | ||
The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis | Q73393601 | ||
Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins | Q73900827 | ||
Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level | Q73904644 | ||
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress | Q77332057 | ||
Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitrite | Q77567629 | ||
Matrix homeostasis in aging normal human ankle cartilage | Q78505454 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | osteoarthritis | Q62736 |
oxidative stress | Q898814 | ||
cartilage | Q502730 | ||
P304 | page(s) | R380-91 | |
P577 | publication date | 2005-01-26 | |
P1433 | published in | Arthritis Research and Therapy | Q15757229 |
P1476 | title | Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function | |
P478 | volume | 7 |
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