Osteoarthritis

scientific article published on 01 December 2007

Osteoarthritis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/JCP.21258
P698PubMed publication ID17786965

P50authorMary B GoldringQ52565525
Steven R GoldringQ114399448
P433issue3
P921main subjectosteoarthritisQ62736
P304page(s)626-634
P577publication date2007-12-01
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleOsteoarthritis
P478volume213

Reverse relations

cites work (P2860)
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Q33880198Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
Q84866436Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix metalloproteinase-13 induced by interleukin-1β in chondrocytes in an intensity-dependent manner
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Q41663962Metabolomics as a promising tool for early osteoarthritis diagnosis
Q33588972MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
Q33885698MicroRNA-140 plays dual roles in both cartilage development and homeostasis
Q36923577MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins
Q50904628MicroRNA-181 inhibits proliferation and promotes apoptosis of chondrocytes in osteoarthritis by targeting PTEN.
Q55333219MicroRNA-193b-3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3.
Q35173703MicroRNAs associated with osteoarthritis differently expressed in bone matrix gelatin (BMG) rat model
Q64915584MicroRNA‑195‑5p inhibitor prevents the development of osteoarthritis by targeting REGγ.
Q54957861Mithramycin A Alleviates Osteoarthritic Cartilage Destruction by Inhibiting HIF-2α Expression.
Q37242365Mitogen-activated protein kinases as therapeutic targets in osteoarthritis
Q92761412Molecular Mechanisms of Intervertebral Disc Degeneration
Q26764941Molecular mechanisms of biological aging in intervertebral discs
Q38128702Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis.
Q33737668Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction
Q58737317N-Methyl Pyrrolidone (NMP) Alleviates Lipopolysaccharide (LPS)-Induced Inflammatory Injury in Articular Chondrocytes
Q91994891NF-κB Signaling Pathways in Osteoarthritic Cartilage Destruction
Q51781232Nanomedicine: AFM tackles osteoarthritis.
Q91737312Nanosome-Mediated Delivery Of Protein Kinase D Inhibitor Protects Chondrocytes From Interleukin-1β-Induced Stress And Apoptotic Death
Q42159890Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules
Q37652102Needle-knife therapy improves the clinical symptoms of knee osteoarthritis by inhibiting the expression of inflammatory cytokines
Q47114989Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression
Q21195404Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis
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Q37417111Nonoperative treatment approach to knee osteoarthritis in the master athlete
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Q36706230Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance
Q47418880Obesity punches above its weight in osteoarthritis
Q92880849Objective Comparison between Platelet Rich Plasma Alone and in Combination with Physical Therapy in Dogs with Osteoarthritis Caused by Hip Dysplasia
Q38355351Osteoarthitis of leptin-deficient ob/ob mice in response to biomechanical loading in micro-CT.
Q61817591Osteoarthritic Synovial Fluid Modulates Cell Phenotype and Metabolic Behavior
Q33900522Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes
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Q89996549Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent?
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Q47632345Potential role of rebamipide in osteoclast differentiation and mandibular condylar cartilage homeostasis
Q38268311Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis
Q35554440Prg4-expressing cells: articular stem cells or differentiated progeny in the articular chondrocyte lineage?
Q80845872Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters
Q50229672Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes
Q92256627Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
Q42316518Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading
Q42253266Prospects for treating osteoarthritis: enzyme-protein interactions regulating matrix metalloproteinase activity.
Q35840732Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability
Q36196730Protective effects of tumor necrosis factor-α blockade by adalimumab on articular cartilage and subchondral bone in a rat model of osteoarthritis
Q35962168Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments.
Q33991241Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction
Q54939944Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.
Q34619757Proteoglycan 4 expression protects against the development of osteoarthritis
Q35552862Pullulan: a new cytoadhesive for cell-mediated cartilage repair.
Q28750441Quantification of condylar resorption in temporomandibular joint osteoarthritis
Q37382402Quantitative MRI of articular cartilage and its clinical applications
Q35677884Quantitative T2 relaxation time and magnetic transfer ratio predict endplate biochemical content of intervertebral disc degeneration in a canine model
Q30545794Quantitative imaging of murine osteoarthritic cartilage by phase-contrast micro-computed tomography
Q36015312RNA Microarray Analysis of Macroscopically Normal Articular Cartilage from Knees Undergoing Partial Medial Meniscectomy: Potential Prediction of the Risk for Developing Osteoarthritis
Q38843434Recent tissue engineering-based advances for effective rAAV-mediated gene transfer in the musculoskeletal system
Q37720056Reduced miR‑26a and miR‑26b expression contributes to the pathogenesis of osteoarthritis via the promotion of p65 translocation
Q41040305Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.
Q36742102Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites
Q34599321Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints
Q37075891Regulation of chondrogenesis and chondrocyte differentiation by stress.
Q36828468Reproductive status and sex show strong effects on knee OA in a baboon model
Q37691824Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization
Q33790090Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis.
Q55023431Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology.
Q46355550Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
Q37323488Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain
Q55171215Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.
Q33598969Role of autophagy in the progression of osteoarthritis: The autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis
Q36031679Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone
Q38254774Role of integrins and their ligands in osteoarthritic cartilage
Q37609032Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.
Q28069429Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
Q42148680Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells
Q92308874STAT3 speeds up progression of osteoarthritis through NF-κB signaling pathway
Q34347383Saponin-rich fraction from Clematis chinensis Osbeck roots protects rabbit chondrocytes against nitric oxide-induced apoptosis via preventing mitochondria impairment and caspase-3 activation
Q35933890Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health
Q52613753Senescent cells and osteoarthritis: a painful connection.
Q47094932Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes.
Q91677802Simvastatin promotes restoration of chondrocyte morphology and phenotype
Q36574611Standardized butanol fraction of WIN-34B suppresses cartilage destruction via inhibited production of matrix metalloproteinase and inflammatory mediator in osteoarthritis human cartilage explants culture and chondrocytes
Q64103454Stem cells: past, present, and future
Q34402219Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes
Q91649324Suppression of inflammatory mediators and matrix metalloproteinase (MMP)-13 by Morus alba stem extract and oxyresveratrol in RAW 264.7 cells and C28/I2 human chondrocytes
Q33820491Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage
Q35014047Synovial joints: from development to homeostasis
Q37349431Synovial perlecan is required for osteophyte formation in knee osteoarthritis
Q33816362Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis
Q34572095Synoviocytes protect cartilage from the effects of injury in vitro
Q51066037Synthesis, Biological Evaluation, and Docking Studies of a Novel Sulfonamido-Based Gallate as Pro-Chondrogenic Agent for the Treatment of Cartilage.
Q64084061T-based fibril-reinforced poroviscoelastic constitutive relation of human articular cartilage using inverse finite element technology
Q92874816TGFβ/BMP Signaling Pathway in Cartilage Homeostasis
Q38289811TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs.
Q90950258Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
Q35217084Targeted mutation of NOV/CCN3 in mice disrupts joint homeostasis and causes osteoarthritis-like disease
Q37209694Telomerase transduced osteoarthritis fibroblast-like synoviocytes display a distinct gene expression profile
Q55002167Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis.
Q92825085The Adipokine Network in Rheumatic Joint Diseases
Q38600704The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.
Q52902373The Expression of Proinflammatory Cytokines and Matrix Metalloproteinases in the Synovial Membranes of Patients With Osteoarthritis Compared With Traumatic Knee Disorders
Q57167183The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis
Q37335286The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2.
Q48132378The analgesic effect of electroacupuncture on inflammatory pain in the rat model of collagenase-induced arthritis: mediation by opioidergic receptors
Q37684848The basic science of the subchondral bone
Q35124848The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone.
Q38979165The danger from within: alarmins in arthritis
Q37424417The degradation of chondrogenic pellets using cocultures of synovial fibroblasts and U937 cells
Q36084922The distribution pattern of critically short telomeres in human osteoarthritic knees
Q88020746The effects of an oral preparation containing hyaluronic acid (Oralvisc®) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses
Q51547598The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study.
Q38965381The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis
Q37213622The future of osteoarthritis therapeutics: targeted pharmacological therapy
Q36765477The horse as a model of naturally occurring osteoarthritis
Q87068972The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study
Q36555344The novel adipokine progranulin counteracts IL-1 and TLR4-driven inflammatory response in human and murine chondrocytes via TNFR1.
Q37231824The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli
Q38734393The role of metabolism in the pathogenesis of osteoarthritis
Q36859928The role of neuromuscular changes in aging and knee osteoarthritis on dynamic postural control
Q35401594The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology
Q37798162The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
Q34009214The roles of catabolic factors in the development of osteoarthritis
Q38245621Tissue-engineering strategies to repair joint tissue in osteoarthritis: nonviral gene-transfer approaches
Q92798762Trans-Cinnamaldehyde Inhibits IL-1β-Stimulated Inflammation in Chondrocytes by Suppressing NF-κB and p38-JNK Pathways and Exerts Chondrocyte Protective Effects in a Rat Model of Osteoarthritis
Q34286451Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes
Q38258523Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes
Q33998768Transcriptional regulation of bone and joint remodeling by NFAT
Q91638878Transcriptome sequencing reveals dynamic changes in matrix metalloproteinases in facet joint osteoarthritis
Q42318954Transglutaminase 2 in cartilage homoeostasis: novel links with inflammatory osteoarthritis.
Q45332098Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo
Q89767962Treating hand and foot osteoarthritis using a patient's own blood: A systematic review and meta-analysis of platelet-rich plasma
Q37190855Trichostatin A increases the TIMP-1/MMP ratio to protect against osteoarthritis in an animal model of the disease
Q35215468Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
Q41192590Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: a retrospective comparative study
Q37426352Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction
Q90637908Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes
Q41456227Viability and Tissue Quality of Cartilage Flaps From Patients With Femoroacetabular Hip Impingement: A Matched-Control Comparison
Q37631434Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways.
Q33825033Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis
Q37002492Vitamin E slows down the progression of osteoarthritis
Q36240347Volumetric quantitative characterization of human patellar cartilage with topological and geometrical features on phase-contrast X-ray computed tomography.
Q33636855Why is osteoarthritis an age-related disease?
Q37691249Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.
Q26774008Wnt signaling in cartilage development and diseases: lessons from animal studies
Q29248654Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis
Q26775922Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis
Q34012380YKL-40 as a novel factor associated with inflammation and catabolic mechanisms in osteoarthritic joints
Q50781192[Effect of power training on articular cartilage].
Q92617467miR-107 modulates chondrocyte proliferation, apoptosis, and extracellular matrix synthesis by targeting PTEN
Q87903836miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis
Q64095964miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse
Q92937637αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis

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