Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner

scientific article

Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M610778200
P698PubMed publication ID17635918
P5875ResearchGate publication ID6202385

P50authorSeong-Il SuhQ118179471
P2093author name stringJong-Wook Park
Dong Hoon Shin
Jong-Gu Park
Gi-Young Park
Byeong-Churl Jang
Jae Hoon Bae
Seung-Bum Han
Su-Haeng Sung
P2860cites workHuman cyclooxygenase-2 cDNAQ24293134
An update on nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitorsQ28193309
Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response elementQ28289531
Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2Q28299729
Mechanisms of glucosamine-induced suppression of the hepatic assembly and secretion of apolipoprotein B-100-containing lipoproteinsQ28573980
Cyclooxygenases 1 and 2Q29615645
Characterization of the glycosylation sites in cyclooxygenase-2 using mass spectrometryQ30659612
Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trialQ32050561
Cyclooxygenase-1 and -2 isoenzymesQ33683638
Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasomeQ34116003
Transcriptional regulation of cyclooxygenase-2 in response to proteasome inhibitors involves reactive oxygen species-mediated signaling pathway and recruitment of CCAAT/enhancer-binding protein delta and CREB-binding proteinQ34148151
Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylationQ35596374
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's diseaseQ35736273
Proteasome inhibitor-induced cyclooxygenase-2 expression in Raw264.7 cells is potentiated by inhibition of c-Jun N-terminal kinase activationQ40308774
Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expressionQ40685221
Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytesQ40794472
Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2).Q40901190
The hexosamine biosynthetic pathway and glucose-induced down regulation of glucose transport in L6 myotubesQ41441488
Glucosamine HCl reduces equine articular cartilage degradation in explant cultureQ42490895
Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1betaQ42548081
The 19-amino acid cassette of cyclooxygenase-2 mediates entry of the protein into the endoplasmic reticulum-associated degradation systemQ42835180
N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cellsQ43984566
Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytesQ44394411
Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscleQ44816710
Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cellsQ44827054
Preventive actions of a high dose of glucosamine on adjuvant arthritis in ratsQ46481855
Glucosamine sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitroQ46907847
Comparative proteomic analysis of de-N-glycosylated serum from hepatitis B carriers reveals polypeptides that correlate with disease statusQ48007732
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
glucosamineQ32907954
P1104number of pages11
P304page(s)27622-27632
P577publication date2007-07-16
P1433published inJournal of Biological ChemistryQ867727
P1476titleGlucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner
P478volume282

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cites work (P2860)
Q38448449Comparison of molecular mechanisms of rheumatoid arthritis and osteoarthritis using gene microarrays
Q46027542Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis.
Q35147261Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids
Q34355831Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes
Q36444055Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25.
Q64914568Glucosamine decreases the stemness of human ALDH+ breast cancer stem cells by inactivating STAT3.
Q37302252Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling
Q41841238Glucosamine suppresses proliferation of human prostate carcinoma DU145 cells through inhibition of STAT3 signaling
Q37163298Menopause-induced uterine epithelium atrophy results from arachidonic acid/prostaglandin E2 axis inhibition-mediated autophagic cell death
Q39523565Overexpression of cyclooxygenase-2 in NCI-H292 human alveolar epithelial carcinoma cells: roles of p38 MAPK, ERK-1/2, and PI3K/PKB signaling proteins
Q49559335Palmitate Induces Glycosylation of Cyclooxygenase-2 in Primary Human Vascular Smooth Muscle Cells
Q60929977Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update
Q36234820Silibinin Inhibits Platelet-Derived Growth Factor-Driven Cell Proliferation via Downregulation of N-Glycosylation in Human Tenon's Fibroblasts in a Proteasome-Dependent Manner
Q37513765The novel IGF-IR/Akt-dependent anticancer activities of glucosamine
Q37600516The ubiquitin-proteasome pathway and endothelial (dys)function
Q45928910The ubiquitin-proteasome pathway and viral infections in articular cartilage of patients with osteoarthritis.

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