In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis

scientific article published on 3 June 2015

In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1027755K
P356DOI10.1371/JOURNAL.PONE.0127755
P932PMC publication ID4454568
P698PubMed publication ID26039063
P5875ResearchGate publication ID277782284

P2093author name stringMarc E Rothenberg
Joseph D Sherrill
Kiran Kc
P2860cites workUltrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivoQ24318871
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
Defining the interactions between intermediate filaments and desmosomesQ24680223
New consensus nomenclature for mammalian keratinsQ24683198
Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermathQ26852211
Epithelial homeostasisQ26864115
Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13Q28237238
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitisQ28264656
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cellsQ28564357
Mouse keratin 4 is necessary for internal epithelial integrityQ28595045
Phylogeny.fr: robust phylogenetic analysis for the non-specialistQ29547666
Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagusQ33379614
Organotypic skin cultureQ33798649
Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitisQ33996008
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic diseaseQ34003041
Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic cultureQ34125957
Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencingQ34143183
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitisQ34331377
Computational methods for transcriptome annotation and quantification using RNA-seqQ34660508
Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skinQ34701888
Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment.Q35923340
Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin modelQ36563609
Esophageal epithelial and mesenchymal cross-talk leads to features of epithelial to mesenchymal transition in vitro.Q36672891
Keratins as the main component for the mechanical integrity of keratinocytes.Q37319476
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systemsQ37697913
Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarrayQ38347517
Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.Q38959847
In vitro assessment of IL-4- or IL-13-mediated changes in the structural components of keratinocytes in mice and humansQ39053919
NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional networkQ39662272
IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.Q40036792
Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation.Q40590626
Retinoic acid disintegrated desmosomes and hemidesmosomes in stratified oral keratinocytesQ42469082
IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathwayQ42559693
Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.Q42935186
Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitisQ45003326
Molecular cloning and expression of human keratinocyte proline-rich protein (hKPRP), an epidermal marker isolated from calcium-induced differentiating keratinocytesQ46811083
Genetic analysis of the epidermal differentiation complex (EDC) on human chromosome 1q21: chromosomal orientation, new markers, and a 6-Mb YAC contigQ48058290
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e0127755
P577publication date2015-06-03
P1433published inPLOS OneQ564954
P1476titleIn vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis
P478volume10

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cites work (P2860)
Q9071483517β-Estradiol protects the esophageal epithelium from IL-13-induced barrier dysfunction and remodeling
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Q38707910Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity.
Q48119996Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis
Q64241109Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14
Q58771202Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth
Q53051464Novel immunologic mechanisms in eosinophilic esophagitis.
Q89866917Pathophysiology of Eosinophilic Esophagitis
Q51180873Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis.
Q92436138Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
Q42517074Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity.
Q38612911TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis.
Q37019844The Immunologic Mechanisms of Eosinophilic Esophagitis.
Q89013389The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses

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