Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

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Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NG.3033
P932PMC publication ID4121957
P698PubMed publication ID25017104
P5875ResearchGate publication ID263897239

P50authorLeah C. KottyanQ43179315
Lisa J. MartinQ43179322
Phillip DexheimerQ52811571
Brian P. VickeryQ56013921
Mark RochmanQ57548578
Benjamin P DavisQ59545708
Hugh A SampsonQ65559603
John B. HarleyQ67209813
P2093author name stringDavid M Fleischer
Robert A Wood
Matthew T Weirauch
Kan Liu
Hua He
Marc E Rothenberg
Mojtaba Kohram
Sara Lazaro
Emily M Stucke
J Pablo Abonia
Joseph D Sherrill
Phil E Putnam
Mirna Chehade
Vincent A Mukkada
Kenneth Kaufman
Robbie D Pesek
Katherine A Kemme
Andrew M Rupert
Samuel Vaughn
Albert Magnusen
Robert Lindbad
P2860cites workJuvenile rheumatoid arthritis: linkage to HLA demonstrated by allele sharing in affected sibpairsQ73092751
Adults with eosinophilic myositis and calpain-3 mutationsQ80771661
Validation of comparative genomic hybridization arrays for the detection of genomic rearrangements of the calpain-3 and dysferlin genesQ82852448
Eosinophilic infiltration related to CAPN3 mutations: a pathophysiological component of primary calpainopathy?Q83123102
Calpainopathy and eosinophilic myositisQ83828184
Expression of interleukin-4 receptor α in human corneal epithelial cellsQ84206805
Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitisQ86541525
Association of the chromosome 11q13.5 variant with atopic dermatitis in Austrian patientsQ86542371
Ultrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resourcesQ21183895
Model-based analysis of ChIP-Seq (MACS)Q21183902
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseQ22251069
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitisQ24596087
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiationQ24627354
TopHat: discovering splice junctions with RNA-SeqQ24655505
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Ensembl 2013Q28280494
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility lociQ28293771
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth orderQ28943336
Common variants at 5q22 associate with pediatric eosinophilic esophagitisQ28943383
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese populationQ28943402
Identification of IL6R and chromosome 11q13.5 as risk loci for asthmaQ29417065
A new multipoint method for genome-wide association studies by imputation of genotypesQ29547209
Integrating common and rare genetic variation in diverse human populationsQ29547220
LocusZoom: regional visualization of genome-wide association scan resultsQ29614868
The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomesQ33777918
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.Q33858072
Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitisQ33996008
Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencingQ34143183
Association analysis of single nucleotide polymorphisms at five loci: comparison between atopic dermatitis and asthma in the Chinese Han populationQ34251107
Genomics: ENCODE explainedQ34297992
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitisQ34331377
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitizationQ34354830
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesisQ35095605
Calpain chronicle--an enzyme family under multidisciplinary characterizationQ35157505
Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis.Q36007742
Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic casesQ37146899
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cellsQ37304003
An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis in miceQ37337702
Eosinophilic esophagitis: concepts, controversies, and evidenceQ37492712
TGFβ receptor mutations impose a strong predisposition for human allergic diseaseQ37526777
Biology and treatment of eosinophilic esophagitisQ37549336
Intrinsic autoimmune capacities of hematopoietic cells from female New Zealand hybrid miceQ37722598
Eosinophilic esophagitis: updated consensus recommendations for children and adultsQ37863307
Eosinophilic esophagitis: rapidly advancing insights.Q37950400
The multifunctional role of filaggrin in allergic skin diseaseQ38078474
Mature interleukin-33 is produced by calpain-mediated cleavage in vivoQ39825950
IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathwayQ42559693
Working with the US Food and Drug Administration: progress and timelines in understanding and treating patients with eosinophilic esophagitisQ42906332
Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.Q42935186
Expression of the interleukin-4 receptor alpha in human conjunctival epithelial cellsQ42977075
Regulation of TET protein stability by calpains.Q42998566
CAPN3 mutations in patients with idiopathic eosinophilic myositis.Q44067094
Increased number of regulatory T cells in children with eosinophilic esophagitisQ45177755
Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease?Q46088563
Increased esophageal regulatory T cells and eosinophil characteristics in children with eosinophilic esophagitis and gastroesophageal reflux diseaseQ47835343
Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution.Q51523100
A common variant on chromosome 11q13 is associated with atopic dermatitis.Q52911781
Association of Eotaxin gene family with asthma and serum total IgE.Q53655337
Regulation of IL-33 expression by IFN-γ and tumor necrosis factor-α in normal human epidermal keratinocytes.Q54506205
ENCODE: The human encyclopaedia.Q55056659
Presenting ENCODEQ59092279
Relative lack of T regulatory cells in adult eosinophilic esophagitis - no normalization after corticosteroid therapyQ61959734
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectgenome-wide association studyQ1098876
eosinophilic esophagitisQ2057356
P304page(s)895-900
P577publication date2014-07-13
P1433published inNature GeneticsQ976454
P1476titleGenome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
P478volume46

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cites work (P2860)
Q50225864A new eosinophilic esophagitis (EoE)-like disease without tissue eosinophilia found in EoE families
Q26778315Allergic mechanisms of Eosinophilic oesophagitis
Q26781368An eccentric calpain, CAPN3/p94/calpain-3
Q42142968Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.
Q38708442Assessing Early Life Factors for Eosinophilic Esophagitis: Lessons From Other Allergic Diseases
Q38600583Association of eosinophilic esophagitis and hypertrophic cardiomyopathy.
Q39004902Calpain research for drug discovery: challenges and potential
Q39107690Calpain-14 and its association with eosinophilic esophagitis.
Q90671442Challenges and updates in the management of eosinophilic esophagitis
Q41010688Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel
Q49186926Current concepts in eosinophilic esophagitis
Q90744590DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study
Q38743690Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis
Q26865894Do We Know What Causes Eosinophilic Esophagitis? A Mechanistic Update
Q50065924Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis
Q36271593Environmental and infectious factors in eosinophilic esophagitis
Q26778699Eosinophilic Esophagitis
Q55085242Eosinophilic Esophagitis Is an Underlying Cause for Gastrointestinal Concerns in Children.
Q38558964Eosinophilic Esophagitis and Gastroenteritis
Q39399982Eosinophilic Esophagitis in Children.
Q55358477Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, and Eosinophilic Colitis: Common Mechanisms and Differences between East and West.
Q38551117Eosinophilic Esophagitis: A Comprehensive Review
Q39211686Eosinophilic Esophagitis: A Primary Disease of the Esophageal Mucosa
Q50054838Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci
Q26751168Eosinophilic esophagitis in adults: An update
Q30244585Eosinophilic esophagitis in an octogenarian: A case report and review of the literature
Q38707910Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity.
Q40961367Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment.
Q26776161Eosinophilic esophagitis: From pathophysiology to treatment
Q39251666Eosinophilic esophagitis: unclear roles of IgE and eosinophils
Q38607299Eosinophilic oesophagitis: a systematic review for otolaryngologists
Q26799615Eosinophils in Gastrointestinal Disorders: Eosinophilic Gastrointestinal Diseases, Celiac Disease, Inflammatory Bowel Diseases, and Parasitic Infections
Q38390424Eosinophils in mucosal immune responses
Q64084903Epigenomics and Transcriptomics in the Prediction and Diagnosis of Childhood Asthma: Are We There Yet?
Q91675729Epithelial barrier repair and prevention of allergy
Q92744570Epithelial cell-derived cytokines: more than just signaling the alarm
Q88781891Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis
Q90534089Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multi-site cohort
Q90714858Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α
Q59153904Food allergy
Q36229922Food allergy and the gut.
Q37012895From genetics to treatment of eosinophilic esophagitis
Q34545768GWAS identifies four novel eosinophilic esophagitis loci
Q58564335Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?
Q88301550Gene expression-phenotype associations in adults with eosinophilic esophagitis
Q57329659Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis
Q55339404Genetic variations in the TLR3 locus are associated with eosinophilic esophagitis.
Q64241109Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14
Q39146390Genetics of eosinophilic esophagitis
Q46703366Genome-wide analyses identify common variants associated with macular telangiectasia type 2.
Q47291888IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis.
Q30276912IgE antibodies and response to cow's milk elimination diet in pediatric eosinophilic esophagitis
Q51720014Immunohistochemical differentiation of eosinophilic esophageal myositis from eosinophilic esophagitis.
Q35650990In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis
Q42369958Interleukin-13 in Asthma and Other Eosinophilic Disorders.
Q36804012LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium
Q43157333Linking impaired skin barrier function to esophageal allergic inflammation via IL-33.
Q37031313Mechanisms of Disease of Eosinophilic Esophagitis.
Q92263913Mechanisms of gastrointestinal allergic disorders
Q35537424Molecular, genetic, and cellular bases for treating eosinophilic esophagitis
Q47273589Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis
Q53051464Novel immunologic mechanisms in eosinophilic esophagitis.
Q40114032Pathophysiology of Eosinophilic Esophagitis
Q89866917Pathophysiology of Eosinophilic Esophagitis
Q47767767Pediatric Eosinophilic Esophagitis Endotypes: Are We Closer to Predicting Treatment Response?
Q34356060Pediatric eosinophilic esophagitis is associated with changes in esophageal microRNAs
Q34531775Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis
Q90741728Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research
Q40053113Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis
Q51180873Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis.
Q36578734Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis
Q42367243Recent advances in eosinophilic esophagitis
Q37091698Recent advances in the pathological understanding of eosinophilic esophagitis
Q26784606Recent advances in understanding/managing eosinophilic esophagitis in adults
Q38853602Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry
Q61959702Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)
Q39742611Risk of Autoimmunity in EoE and Families: A Population-Based Cohort Study
Q92436138Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
Q42517074Synaptopodin is upregulated by IL-13 in eosinophilic esophagitis and regulates esophageal epithelial cell motility and barrier integrity.
Q34892932Systems biology of asthma and allergic diseases: a multiscale approach
Q90859104TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis
Q36144745TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis
Q52649431The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes.
Q37019844The Immunologic Mechanisms of Eosinophilic Esophagitis.
Q90387813The Role of the Environment in Eosinophilic Esophagitis
Q89013389The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses
Q38813019The role of proton pump inhibitor therapy in the management of eosinophilic esophagitis
Q64902210Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer.
Q52319664Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity.
Q34619938Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis
Q45069324Using Serum IgE Antibodies to Predict Esophageal Eosinophilia in Children
Q26765021Wheat allergy: diagnosis and management
Q52691460Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.

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