GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells

scholarly article

GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..10613445T
P356DOI10.1073/PNAS.0901944106
P932PMC publication ID2726354
P698PubMed publication ID19651619
P5875ResearchGate publication ID26713911

P50authorJohn AnderssonQ55293542
P2093author name stringRui Wang
Heather Ramsey
Derya Unutmaz
Ethan M Shevach
Dat Q Tran
P2860cites workThe GARP gene encodes a new member of the family of leucine-rich repeat-containing proteinsQ24313285
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent mannerQ24656647
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Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiologyQ28138090
Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinomaQ28266887
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteinsQ28280925
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expressionQ28593882
Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteinsQ30487560
TGF-beta and regulatory T cell in immunity and autoimmunityQ33722462
Latent-TGF-beta: an overviewQ34251623
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinomaQ35792001
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null miceQ36117987
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsivenessQ36370807
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion culturesQ37201964
Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomasQ38313599
Gene amplifications associated with the development of hormone-resistant prostate cancerQ38450128
Pharmacogenomic approach for the identification of novel determinants of acquired resistance to oxaliplatin in colorectal cancerQ39896205
Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein.Q41193486
TGF-beta latency: biological significance and mechanisms of activationQ41487221
Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptideQ44617709
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and miceQ44714971
Usher syndrome in the Samaritans: strengths and limitations of using inbred isolated populations to identify genes causing recessive disorders.Q50507468
Activation requirements for the induction of CD4+CD25+ T cell suppressor functionQ56903555
Amplification of the BRCA2 Pathway Gene EMSY in Sporadic Breast Cancer Is Related to Negative OutcomeQ57287473
Mutations in the gene encoding the latency-associated peptide of TGF-β1 cause Camurati-Engelmann diseaseQ57849197
Role and Regulation of the Serum- and Glucocorticoid-Regulated Kinase 1 in Fertile and Infertile Human EndometriumQ59102101
Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3Q60452054
New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regionsQ68069200
Release and activation of platelet latent TGF–β in blood clots during dissolution with plasminQ71803700
11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5.Q73510704
Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomasQ79401919
Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent mannerQ79984729
Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-betaQ80358435
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectLeucine rich repeat containing 32Q21108890
regulation of transforming growth factor beta activationQ22301626
P1104number of pages6
P304page(s)13445-13450
P577publication date2009-07-27
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells
P478volume106

Reverse relations

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