Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis

scientific article published on 19 December 2017

Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis is …
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scholarly articleQ13442814

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P356DOI10.1242/DMM.030767
P932PMC publication ID5769607
P698PubMed publication ID29259025

P50authorBettina HeidQ67121105
P2093author name stringIrving C Allen
Kristin Eden
Daniel E Rothschild
Dylan K McDaniel
P2860cites workAn etiological role for aeroallergens and eosinophils in experimental esophagitisQ24682860
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NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activationQ36493668
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TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammationQ36798825
FGF9-induced proliferative response to eosinophilic inflammation in oesophagitisQ37020516
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Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.Q37178911
NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-κB signalingQ37362848
Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitisQ37448788
Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M.Q37584293
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.Q37632813
T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis.Q37710944
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Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease PathobiologyQ41492918
Pathogenesis of allergen-induced eosinophilic esophagitis is independent of interleukin (IL)-13.Q42001808
Characterizing the inflammatory response in esophageal mucosal biopsies in children with eosinophilic esophagitis.Q42197997
IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathwayQ42559693
Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitisQ42947882
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signalingQ43142702
Esophageal remodeling in pediatric eosinophilic esophagitisQ46304660
Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100.Q46751773
Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitisQ48119996
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue12
P921main subjectNF-κBQ411114
eosinophilic esophagitisQ2057356
P304page(s)1517-1527
P577publication date2017-12-19
P1433published inDisease Models & MechanismsQ1524006
P1476titleNoncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis
P478volume10