Transcriptional and Post-Transcriptional Modulation of SPI1 and SPI2 Expression by ppGpp, RpoS and DksA in Salmonella enterica sv Typhimurium

scientific article published on 3 June 2015

Transcriptional and Post-Transcriptional Modulation of SPI1 and SPI2 Expression by ppGpp, RpoS and DksA in Salmonella enterica sv Typhimurium is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1027523R
P356DOI10.1371/JOURNAL.PONE.0127523
P8608Fatcat IDrelease_ondlarumunarlp5c4lqh3ym3xi
P932PMC publication ID4454661
P698PubMed publication ID26039089
P5875ResearchGate publication ID277709789

P2093author name stringArthur Thompson
Neil Shearer
Christopher J Rice
Vinoy K Ramachandran
P2860cites workRpoS controls the Vibrio cholerae mucosal escape responseQ21559520
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(p)ppGpp: still magical?Q28278758
The stringent response of Mycobacterium tuberculosis is required for long-term survivalQ28486427
Pseudomonas aeruginosa relA contributes to virulence in Drosophila melanogasterQ28493313
Involvement of quorum sensing and RpoS in rice seedling blight caused by Burkholderia plantarii.Q51206782
ppGpp with DksA controls gene expression in the locus of enterocyte effacement (LEE) pathogenicity island of enterohaemorrhagic Escherichia coli through activation of two virulence regulatory genes.Q53613130
Use of the tetracycline promoter for the tightly regulated production of a murine antibody fragment in Escherichia coliQ57260264
DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTPQ80417641
Signal pathway in salt-activated expression of the Salmonella pathogenicity island 1 type III secretion system in Salmonella enterica serovar TyphimuriumQ39759687
During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systemsQ40046693
Induction of expression of hfq by DksA is essential for Shigella flexneri virulenceQ40223748
HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar Typhimurium.Q40402350
ppGpp-dependent stationary phase induction of genes on Salmonella pathogenicity island 1.Q40552048
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes.Q41481361
Identical, independent, and opposing roles of ppGpp and DksA in Escherichia coliQ41790469
A proximal promoter element required for positive transcriptional control by guanosine tetraphosphate and DksA protein during the stringent response.Q41960551
Similar and divergent effects of ppGpp and DksA deficiencies on transcription in Escherichia coliQ43121907
ppGpp-mediated stationary phase induction of the genes encoded by horizontally acquired pathogenicity islands and cob/pdu locus in Salmonella enterica serovar TyphimuriumQ43134134
A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila.Q43967545
The bacterial signal molecule, ppGpp, regulates Salmonella virulence gene expressionQ44928503
ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor sigmaE in Escherichia coli by both direct and indirect mechanisms.Q46845845
Increased distal gene transcription by the elongation factor RfaH, a specialized homologue of NusG.Q48058210
Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytesQ50032899
The bacterial signal molecule, ppGpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of SalmonellaQ50077977
RpoS and RpoN are involved in the growth-dependent regulation of rfaH transcription and O antigen expression in Salmonella enterica serovar TyphiQ50102133
AraC/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimurium.Q50105717
Effects of DksA and ClpP protease on sigma S production and virulence in Salmonella typhimuriumQ50123216
Role of rpoS in stress survival and virulence of Vibrio choleraeQ32115865
The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stressQ33739903
DksA potentiates direct activation of amino acid promoters by ppGppQ33841173
ppGpp conjures bacterial virulenceQ33909091
dksA is required for intercellular spread of Shigella flexneri via an RpoS-independent mechanism.Q34009042
The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium during invasion gene expressionQ34129364
The Stringent Response Is Required for Full Virulence ofMycobacterium tuberculosisin Guinea PigsQ34172559
The RpoS-mediated general stress response in Escherichia coliQ34189650
Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulationQ34336985
ppGpp: a global regulator in Escherichia coli.Q34415352
Listeria monocytogenes relA and hpt mutants are impaired in surface-attached growth and virulenceQ34434579
A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genomeQ34707860
Posttranscriptional control of quorum-sensing-dependent virulence genes by DksA in Pseudomonas aeruginosaQ35021121
Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilDQ35049823
Down-regulation of key virulence factors makes the Salmonella enterica serovar Typhimurium rfaH mutant a promising live-attenuated vaccine candidateQ35073942
The primary transcriptome of Salmonella enterica Serovar Typhimurium and its dependence on ppGpp during late stationary phaseQ35130307
Mutation in the relA gene of Vibrio cholerae affects in vitro and in vivo expression of virulence factorsQ35171833
Characterization of the RpoS status of clinical isolates of Salmonella entericaQ35210751
DksA-dependent resistance of Salmonella enterica serovar Typhimurium against the antimicrobial activity of inducible nitric oxide synthaseQ35867530
Growth versus maintenance: a trade-off dictated by RNA polymerase availability and sigma factor competition?Q35937169
rRNA transcription in Escherichia coliQ35965873
The Salmonella typhimurium katF (rpoS) gene: cloning, nucleotide sequence, and regulation of spvR and spvABCD virulence plasmid genesQ35980209
Synthesis of the stationary-phase sigma factor sigma s is positively regulated by ppGppQ36124805
Identification and characterization of a new Escherichia coli gene that is a dosage-dependent suppressor of a dnaK deletion mutationQ36160158
General pathway for turning on promoters transcribed by RNA polymerases containing alternative sigma factorsQ36513675
Role of the DksA-like protein in the pathogenesis and diverse metabolic activity of Campylobacter jejuniQ36747360
Salmonellae interplay with host cellsQ37008201
The alternative sigma factor katF (rpoS) regulates Salmonella virulenceQ37346357
Role of RpoS in virulence of pathogens.Q37641571
ppGpp: magic beyond RNA polymeraseQ37984220
Salmonella T3SSs: successful mission of the secret(ion) agents.Q38072180
The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS.Q39332980
Expression of the antifeeding gene anfA1 in Serratia entomophila requires rpoS.Q39485954
Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression.Q39678018
Integrating global regulatory input into the Salmonella pathogenicity island 1 type III secretion systemQ39694438
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectSalmonella entericaQ2264864
P304page(s)e0127523
P577publication date2015-06-03
P1433published inPLOS OneQ564954
P1476titleTranscriptional and Post-Transcriptional Modulation of SPI1 and SPI2 Expression by ppGpp, RpoS and DksA in Salmonella enterica sv Typhimurium
P478volume10

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cites work (P2860)
Q53704376Conversion of RpoS- Attenuated Salmonella enterica Serovar Typhi Vaccine Strains to RpoS+ Improves Their Resistance to Host Defense Barriers.
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Q55347977Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region.
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Q90398268Salmonella Virulence and Immune Escape
Q89881639SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome
Q36411013The Stringent Response Regulator DksA Is Required for Salmonella enterica Serovar Typhimurium Growth in Minimal Medium, Motility, Biofilm Formation, and Intestinal Colonization

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