A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media

scientific article published on 20 November 2006

A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media is …
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scholarly articleQ13442814

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P356DOI10.1016/J.MOLIMM.2006.10.008
P932PMC publication ID1817667
P698PubMed publication ID17113647
P5875ResearchGate publication ID6683546

P50authorRobert S. MunsonQ68296620
Lauren O BakaletzQ78772868
P2093author name stringCharles L Bevins
Glen McGillivary
William C Ray
P2860cites workAcute respiratory illness in an American community. The Tecumseh studyQ68672836
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Processing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vaginaQ24302168
FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testisQ24306578
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursorQ24569680
LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cellsQ24675869
The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surfaceQ24680172
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The solution structure of the active domain of CAP18 — a lipopolysaccharide binding protein from rabbit leukocytesQ27729827
Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3Q28117302
The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populationsQ28142106
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Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft modelQ33849677
The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxinQ33863111
The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6.Q33867656
Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillasQ33910465
The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infectionQ33981270
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Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challengeQ34004339
Innate antimicrobial peptide protects the skin from invasive bacterial infectionQ34102960
Defensins of vertebrate animalsQ34109303
Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factorsQ34198845
The microbiologic and immunologic basis for recurrent otitis media in childrenQ34320861
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Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitisQ37623570
Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract.Q38315085
Adenovirus serotype 1 does not act synergistically with Moraxella (Branhamella) catarrhalis to induce otitis media in the chinchillaQ39823299
Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis mediaQ39860067
Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37.Q40410408
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.Q40425524
Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domainQ40432691
Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivoQ40575765
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.Q42161372
Adherence of type I Streptococcus pneumoniae to tracheal epithelium of mice infected with influenza A/PR8 virusQ42525988
Phylogeny, processing and expression of the rat cathelicidin rCRAMP: a model for innate antimicrobial peptidesQ42598823
Effect of Endotoxin on Cultured Chinchilla Middle Ear EpitheliumQ43410550
Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A StreptococcusQ43566314
Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.Q43639842
Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptorQ44074391
Overall cost in the treatment of otitis mediaQ45103023
Measuring the indirect and direct costs of acute otitis mediaQ45116242
Eustachian tube histopathology during experimental influenza A virus infection in the chinchillaQ45830707
Primary culture of chinchilla middle ear epithelium.Q46031697
Isolation of cDNA encoding guinea pig neutrophil cationic antibacterial polypeptide of 11 kDa (CAP11) and evaluation of CAP11 mRNA expression during neutrophil maturationQ46190482
Cathelicidin antimicrobial peptides are expressed in salivary glands and salivaQ46204499
Expression and activity of beta-defensins and LL-37 in the developing human lungQ47862114
The antimicrobial peptide rCRAMP is present in the central nervous system of the rat.Q48871467
Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.Q51660498
Multinational study of pneumococcal serotypes causing acute otitis media in children.Q53949873
Expression of bioactive recombinant GSLL-39, a variant of human antimicrobial peptide LL-37, in Escherichia coli.Q53961856
Antimicrobial peptide LL-37 is upregulated in chronic nasal inflammatory disease.Q54785355
Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulatorQ57940216
P433issue9
P921main subjectChinchillaQ192930
antimicrobial peptideQ1201508
P304page(s)2446-2458
P577publication date2006-11-20
P1433published inMolecular ImmunologyQ6895954
P1476titleA member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media
P478volume44

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cites work (P2860)
Q41911574A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin
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Q41193264Host Antimicrobial Peptides in Bacterial Homeostasis and Pathogenesis of Disease
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Q36976255Use of the Chinchilla model to evaluate the vaccinogenic potential of the Moraxella catarrhalis filamentous hemagglutinin-like proteins MhaB1 and MhaB2.

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