| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2012PNAS..109.1239A |
| P356 | DOI | 10.1073/PNAS.1120385109 |
| P932 | PMC publication ID | 3268303 |
| P698 | PubMed publication ID | 22232678 |
| P5875 | ResearchGate publication ID | 221736131 |
| P50 | author | Gregg L. Semenza | Q1545025 |
| P2093 | author name string | J T Sylvester | |
| Larissa A Shimoda | |||
| Allen C Myers | |||
| Ari L Zaiman | |||
| Clark Undem | |||
| Edsel M Abud | |||
| Julie Maylor | |||
| Arjun Punjabi | |||
| P2860 | cites work | HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing | Q24291102 |
| Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension | Q24307473 | ||
| A new mathematical model for relative quantification in real-time RT-PCR | Q27860781 | ||
| Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation | Q27860876 | ||
| Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells | Q28257426 | ||
| Hypoxia-inducible factors in the kidney | Q28303287 | ||
| Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha | Q28508120 | ||
| Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes | Q28566041 | ||
| Sodium-hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes | Q28568918 | ||
| An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension | Q28576675 | ||
| Purification and characterization of hypoxia-inducible factor 1 | Q28678375 | ||
| Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth | Q33385608 | ||
| Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. | Q33471430 | ||
| Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization | Q33868764 | ||
| Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization | Q35006577 | ||
| Cellular and molecular pathobiology of pulmonary arterial hypertension | Q35803229 | ||
| Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia | Q36808053 | ||
| Hypoxia and chronic lung disease. | Q37015304 | ||
| The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. | Q37403106 | ||
| Cellular and molecular basis of pulmonary arterial hypertension | Q37465320 | ||
| HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease | Q37829597 | ||
| Some aspects of pharmacokinetic and biotransformation differences in humans and mammal animals | Q39618312 | ||
| The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin | Q40851439 | ||
| The use of digitalis in patients with pulmonary disease | Q41386466 | ||
| Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells | Q42495592 | ||
| Hypoxic pulmonary vasoconstriction in intact rat intrapulmonary arteries is not initiated by inhibition of Na+-Ca2+ exchange | Q42515420 | ||
| The effect of digoxin on cardiovascular responses to hypoxia and reoxygenation in anesthetized dogs. | Q51861189 | ||
| Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes. | Q52201951 | ||
| HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. | Q53618498 | ||
| Stimulation of vascular smooth muscle sodium, potassium--adenosinetriphosphatase by vasodilators. | Q53752982 | ||
| Cellular Mechanisms that Control Pulmonary Vascular Tone during Hypoxia and Normoxia: Possible Role of Ca2+ATPases | Q54269957 | ||
| Calcium-induced pulmonary vasodilation: modification by meclofenamate and ouabain | Q70391511 | ||
| Hypoxia impairs nitrovasodilator-induced pulmonary vasodilation: role of Na-K-ATPase activity | Q71404735 | ||
| Digitalis intoxication. A prospective clinical study with serum level correlations | Q71780262 | ||
| Mechanisms of hypoxic vasoconstriction in the canine isolated pulmonary artery: role of endothelium and sodium pump | Q72158643 | ||
| L-type Ca(2+) channels, resting [Ca(2+)](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes | Q73127465 | ||
| Role of Na(+)-K(+)-ATPase in sodium nitroprusside-induced relaxation of pulmonary artery under hypoxia | Q73712393 | ||
| Differential regulation of Na/K-ATPase alpha-subunit isoform gene expressions in cardiac myocytes by ouabain and other hypertrophic stimuli | Q73955503 | ||
| Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia | Q74014913 | ||
| Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis | Q74845878 | ||
| The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension | Q77318711 | ||
| Pulmonary hypertension | Q80884934 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hypoxia | Q105688 |
| digoxin | Q422222 | ||
| pulmonary hypertension | Q1128595 | ||
| P304 | page(s) | 1239-1244 | |
| P577 | publication date | 2012-01-09 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Digoxin inhibits development of hypoxic pulmonary hypertension in mice | |
| P478 | volume | 109 |
| Q42413284 | "A small leak will sink a great ship": hypoxia-inducible factor and group III pulmonary hypertension |
| Q26741122 | "Oxygen Sensing" by Na,K-ATPase: These Miraculous Thiols |
| Q42415178 | 55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. |
| Q46280881 | A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension |
| Q27026643 | A comprehensive review: the evolution of animal models in pulmonary hypertension research; are we there yet? |
| Q36764714 | Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. |
| Q37487004 | Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. |
| Q37054481 | Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. |
| Q94560908 | Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway |
| Q91997820 | Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages |
| Q28397747 | Digoxin downregulates NDRG1 and VEGF through the inhibition of HIF-1α under hypoxic conditions in human lung adenocarcinoma A549 cells |
| Q36041722 | Digoxin inhibits PDGF-BB-induced VSMC proliferation and migration through an increase in ILK signaling and attenuates neointima formation following carotid injury |
| Q33723858 | Effects of 17β-estradiol and 2-methoxyestradiol on the oxidative stress-hypoxia inducible factor-1 pathway in hypoxic pulmonary hypertensive rats |
| Q35887239 | Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling |
| Q37679350 | HIF and pulmonary vascular responses to hypoxia |
| Q36810837 | Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development |
| Q33920050 | Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension |
| Q36178060 | Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1 |
| Q47292596 | Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease |
| Q36068993 | Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning |
| Q37057231 | Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases |
| Q92984589 | Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension |
| Q36717280 | Low ambient oxygen prevents atherosclerosis |
| Q38804579 | Lung Circulation |
| Q89344744 | Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension |
| Q38558147 | Molecular mechanisms of hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension |
| Q49203906 | Murine Models of Heart Failure with Preserved Ejection Fraction: a "Fishing Expedition". |
| Q35665720 | Na(+)/H(+) exchange and hypoxic pulmonary hypertension |
| Q38128383 | Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology |
| Q36902375 | Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension |
| Q90963815 | Pharmacologic Targeting of Hypoxia-Inducible Factors |
| Q90625006 | Potential Contribution of Carotid Body-Induced Sympathetic and Renin-Angiotensin System Overflow to Pulmonary Hypertension in Intermittent Hypoxia |
| Q40374764 | Protective effects of heat shock protein 70 against hypoxic pulmonary hypertension in neonatal rats |
| Q37555431 | Pulmonary vascular and ventricular dysfunction in the susceptible patient (2015 Grover Conference series). |
| Q37688525 | Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α. |
| Q39710763 | Role of Rho kinase and Na+/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration |
| Q35115789 | The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes |
| Q89167704 | Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in Pulmonary Arterial Hypertension with a HIF-2α Inhibitor |
| Q35686329 | Upregulation of canonical transient receptor potential channel in the pulmonary arterial smooth muscle of a chronic thromboembolic pulmonary hypertension rat model. |
| Q36644607 | Vascular remodeling in pulmonary hypertension |
| Q47602826 | Withania somnifera shows a protective effect in monocrotaline-induced pulmonary hypertension |
| Q37556377 | miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation |
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