"A small leak will sink a great ship": hypoxia-inducible factor and group III pulmonary hypertension

scientific article published on 14 March 2016

"A small leak will sink a great ship": hypoxia-inducible factor and group III pulmonary hypertension is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.14800/RCI.1213
P932PMC publication ID4950984
P698PubMed publication ID27446973

P2093author name stringEdward W Scott
Andrew J Bryant
P2860cites workHypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cellsQ37374378
CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line, HCS-2/8, under hypoxic conditionQ37384251
Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblastQ39726511
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxiaQ39752665
A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leakQ43119194
β-Catenin and CCNs in lung epithelial repairQ43165591
In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic ratsQ45861620
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic ratsQ46697023
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leakQ46726814
Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.Q54083831
Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity.Q54441527
Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungsQ67432246
Acute hypoxia increases cytosolic calcium in cultured pulmonary arterial myocytesQ72961208
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosisQ24650922
CCN3 and calcium signalingQ24806123
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targetsQ28254386
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alphaQ28508120
Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytesQ28571584
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertensionQ28576675
Incidence and prevalence of idiopathic pulmonary fibrosisQ33997249
A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosisQ34619709
Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasionQ35676352
Digoxin inhibits development of hypoxic pulmonary hypertension in miceQ35709083
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1Q36178060
Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosisQ36352101
Ca2+ channels and pulmonary endothelial permeability: insights from study of intact lung and chronic pulmonary hypertension.Q36645353
Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertensionQ36817403
Pulmonary hypertension in idiopathic pulmonary fibrosis.Q36943245
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in ratsQ37170742
A novel channelopathy in pulmonary arterial hypertensionQ37219463
P433issue1
P407language of work or nameEnglishQ1860
P577publication date2016-03-14
P1433published inReceptors & clinical investigationQ27725368
P1476title"A small leak will sink a great ship": hypoxia-inducible factor and group III pulmonary hypertension
P478volume3

Reverse relations

cites work (P2860)
Q89344744Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension
Q92589761RhoGTPase in Vascular Disease

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