Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries

scientific article published on 10 August 2006

Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2006.08.022
P932PMC publication ID1850147
P698PubMed publication ID16959235
P5875ResearchGate publication ID6831559

P50authorSteffen ScholppQ37829813
Michael BrandQ50583632
Cecilia B. MoensQ55692076
Timothy EricksonQ59110153
P2093author name stringAndrew Jan Waskiewicz
P2860cites workStructure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formationQ22008845
The transcription factor Engrailed-2 guides retinal axonsQ24293543
Pbx3 deficiency results in central hypoventilationQ24670007
Proteomics of early zebrafish embryosQ25255768
Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complexQ27617465
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posteriorQ27641842
Compartments and their boundaries in vertebrate brain developmentQ28256915
Segmentation in the chick embryo hindbrain is defined by cell lineage restrictionsQ28280395
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteinsQ28300459
Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogsQ28508521
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiationQ28512034
Pbx1 is essential for adrenal development and urogenital differentiationQ28513226
The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomainQ28574370
PDX:PBX complexes are required for normal proliferation of pancreatic cells during developmentQ28578151
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expressionQ28585137
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brainQ28586297
The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liverQ28586454
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitusQ28588048
Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mappingQ28768597
The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteinsQ33889933
Neural plate patterning: upstream and downstream of the isthmic organizerQ34185965
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternumQ34323246
Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizerQ34337070
Rostral optic tectum acquires caudal characteristics following ectopic engrailed expressionQ34396938
Hox cofactors in vertebrate developmentQ34499501
Polarity and laminar formation of the optic tectum in relation to retinal projectionQ35685279
An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motifQ35850266
Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx.Q35900314
Divide et Impera--the midbrain-hindbrain boundary and its organizerQ35947525
Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2Q36683631
Engrailed cooperates with extradenticle and homothorax to repress target genes in DrosophilaQ37215807
Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain--hindbrain boundary developmentQ38298389
FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain.Q38364037
Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.Q39716685
Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent mannerQ40500223
The EphA4 receptor tyrosine kinase is necessary for the guidance of nasal retinal ganglion cell axons in vitroQ40841430
Molecular mechanism of polyhomeotic activation by EngrailedQ41029200
The roles of engrailedQ41064626
Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteinsQ41078307
The Eph family in retinal axon guidanceQ41353205
Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity.Q42453883
A short region of its homeodomain is necessary for engrailed nuclear export and secretionQ42814221
Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potentialQ42828894
Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain.Q43633060
Otx2andGbx2are required for refinement and not induction of mid-hindbrain gene expressionQ43826745
Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identityQ44066543
Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axonsQ44790745
The zebrafish buttonhead-like factor Bts1 is an early regulator ofpax2.1expression during mid-hindbrain developmentQ44902326
vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish.Q45040929
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.Q45944197
Midbrain development induced by FGF8 in the chick embryo.Q46013905
extradenticle raises the DNA binding specificity of homeotic selector gene productsQ46446845
Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain proteinQ47072708
Integrity of the midbrain region is required to maintain the diencephalic–mesencephalic boundary in zebrafishno isthmus/pax2.1mutantsQ47073181
lazarus is a novel pbx gene that globally mediates hox gene function in zebrafishQ47073219
Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalonQ47073461
Eliminating zebrafish pbx proteins reveals a hindbrain ground state.Q47073477
Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signalingQ47073539
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisQ47073664
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundaryQ47073721
Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrainQ47073829
Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiationQ47074133
Homeodomain to hexapeptide or PBC-interaction-domain distance: size apparently matters.Q47430717
Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentinoQ48041265
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression.Q48282491
A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary.Q48307151
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitumQ48480210
Establishment of hindbrain segmental identity requires signaling by FGF3 and FGF8.Q48546899
Establishment of rostrocaudal polarity in tectal primordium: engrailed expression and subsequent tectal polarityQ48615069
The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesisQ48680174
Lineage restriction maintains a stable organizer cell population at the zebrafish midbrain-hindbrain boundaryQ48852939
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain regionQ49141522
Requirements for transcriptional repression and activation by Engrailed in Drosophila embryosQ52110663
Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate.Q52173701
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbxQ52537224
Über Entwickelungsgeschichte der Thiere. Beobachtung und Reflexion ..Q56656641
A Role for Gradient en Expression in Positional Specification on the Optic TectumQ63987363
Pluripotentiality of the 2-day-old avian germinative neuroepitheliumQ68759905
Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and Engrailed proteinsQ73124224
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)504-517
P577publication date2006-08-10
P1433published inDevelopmental BiologyQ3025402
P1476titlePbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries
P478volume301

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cites work (P2860)
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Q30451387Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation
Q100385901H2O2 and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum
Q50696862HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia
Q34128072Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system.
Q47131806Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.
Q38073140Novel mechanisms that pattern and shape the midbrain-hindbrain boundary
Q33290989Pbx homeodomain proteins pattern both the zebrafish retina and tectum.
Q51847771Pbx-dependent regulation oflbxgene expression in developing zebrafish embryos
Q47074113Pbx1 is essential for growth of zebrafish swim bladder
Q28585025Pbx3 is required for normal locomotion and dorsal horn development
Q89864872Pbx4 limits heart size and fosters arch artery formation by partitioning second heart field progenitors and restricting proliferation
Q52602912Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock.
Q37596069TALE factors poise promoters for activation by Hox proteins
Q55514652TALE factors use two distinct functional modes to control an essential zebrafish gene expression program.
Q26825693TALE transcription factors during early development of the vertebrate brain and eye
Q48985796TALE-class homeodomain transcription factors, homothorax and extradenticle, control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain
Q43177966The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis.
Q36125301The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons
Q28607311The origin and evolution of chordate nervous systems
Q27021998The role of homeobox genes in retinal development and disease
Q49114792Zebrafish Tshz3b negatively regulates Hox function in the developing hindbrain.
Q42590691Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression

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