Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer

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Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/DEV.01898
P932PMC publication ID1361118
P698PubMed publication ID15944182
P5875ResearchGate publication ID7798577

P50authorRobert D. RiddleQ107437194
P2093author name stringDaniel S Kessler
Lily L Wong
F Patrick O'Hara
Ernestine Beck
Lauren K Barr
P2860cites workStructures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitorsQ27737008
Stages of embryonic development of the zebrafishQ27860947
Identification of a Human LMX1 (LMX1.1)-Related Gene, LMX1.2: Tissue-Specific Expression and Linkage Mapping on Chromosome 9Q28259819
Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limbQ28291179
Localization of the Genes Encoding Two Transcription Factors, LMX1 and CDX3, Regulating Insulin Gene Expression to Human Chromosomes 1 and 13Q28298918
The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic graftsQ28302345
The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryoQ28302373
Pax2 contributes to inner ear patterning and optic nerve trajectoryQ28511597
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brainQ28586297
Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain regionQ28592616
Induction of ectopic engrailed expression and fate change in avian rhombomeres: intersegmental boundaries as barriers.Q52208236
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrateQ52218193
Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryoQ63487544
Pluripotentiality of the 2-day-old avian germinative neuroepitheliumQ68759905
Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous systemQ72106566
A mitogen gradient of dorsal midline Wnts organizes growth in the CNSQ77960718
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar developmentQ28593581
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombinationQ29615355
fork head domain genes in zebrafishQ32048619
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complexQ34244863
Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system.Q34319673
Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternumQ34323246
Early anterior/posterior patterning of the midbrain and cerebellumQ34345487
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene functionQ34434576
The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidneyQ35934032
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b.Q38314171
Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundaryQ38521067
Involvement of Wnt1 and Pax2 in the formation of the midbrain‐hindbrain boundary in the zebrafish gastrulaQ38532050
Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer.Q40783129
Engrailed, Wnt and Pax genes regulate midbrain--hindbrain developmentQ41064646
The cellular environment controls the expression of engrailed-like protein in the cranial neuroepithelium of quail-chick chimeric embryosQ41136089
Early mesencephalon/metencephalon patterning and development of the cerebellumQ41724283
Otx2andGbx2are required for refinement and not induction of mid-hindbrain gene expressionQ43826745
Lmx1b, Pet-1, andNkx2.2Coordinately Specify Serotonergic Neurotransmitter PhenotypeQ44645621
Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formationQ44899280
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.Q45944197
Midbrain development induced by FGF8 in the chick embryo.Q46013905
Dorsal cell fate specified by chick Lmx1 during vertebrate limb developmentQ46565708
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) functionQ47073232
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisQ47073664
A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundaryQ47073721
Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrainQ47073829
Role of Pax-5 in the regulation of a mid-hindbrain organizer's activityQ47938578
Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome.Q48038093
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genesQ48077000
Patterning of the embryonic avian midbrain after experimental inversions: a polarizing activity from the isthmusQ48127024
Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.Q48169771
Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projectionQ48193012
Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain.Q48208878
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression.Q48282491
Plasticity and rigidity of differentiation of brain vesicles studied in quail-chick chimerasQ48290171
Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain.Q48295357
Expression of Gbx-2 during early development of the chick embryoQ48378620
Expression of the homeobox gene GBX2 during chicken developmentQ48378641
Nested expression domains of four homeobox genes in developing rostral brainQ48444447
Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalonQ48451883
Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development.Q48460099
Establishment of rostrocaudal polarity in tectal primordium: engrailed expression and subsequent tectal polarityQ48615069
Induction of a mesencephalic phenotype in the 2-day-old chick prosencephalon is preceded by the early expression of the homeobox gene en.Q48717668
Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrainQ48791624
Cell death in the CNS of the Wnt-1 mutant mouseQ48881359
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer.Q52169436
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectDanio rerioQ169444
P1104number of pages11
P304page(s)3163-3173
P577publication date2005-06-08
P1433published inDevelopmentQ3025404
P1476titleZebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer
P478volume132

Reverse relations

cites work (P2860)
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Q41866526Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis

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