A novel role for FOXA2 and SHH in organizing midbrain signaling centers

scientific article published on June 27, 2012

A novel role for FOXA2 and SHH in organizing midbrain signaling centers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2012.06.018
P953full work available online athttps://api.elsevier.com/content/article/PII:S0012160612003478?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0012160612003478?httpAccept=text/xml
https://doi.org/10.1016/j.ydbio.2012.06.018
https://europepmc.org/articles/PMC3423079
https://europepmc.org/articles/PMC3423079?pdf=render
P932PMC publication ID3423079
P698PubMed publication ID22750257
P5875ResearchGate publication ID228101932

P2093author name stringSeema Agarwala
Charmaine Y. Brown
Roy D. Bayly
P2860cites workThe foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old ageQ21090191
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitroQ24315704
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionQ28291924
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1Q28296269
Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouseQ28505446
Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb budQ28508374
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain regionQ28511592
Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signalingQ28571762
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plateQ28573016
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cordQ28586729
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidanceQ28587510
Identification of intrinsic determinants of midbrain dopamine neuronsQ46913434
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafishQ47073417
Two distinct cell populations in the floor plate of the zebrafish are induced by different pathwaysQ47074194
Sonic hedgehog control of size and shape in midbrain pattern formationQ47216846
Control of roof plate development and signaling by Lmx1b in the caudal vertebrate CNS.Q47296401
Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plateQ48090165
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate.Q48092092
Regulation of ventral midbrain patterning by Hedgehog signalingQ48165671
The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structuresQ48190003
A role for midbrain arcs in nucleogenesisQ48451290
Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development.Q48460099
The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous systemQ48766492
Lmx1a and Lmx1b Function Cooperatively to Regulate Proliferation, Specification, and Differentiation of Midbrain Dopaminergic ProgenitorsQ48924532
Dual origin of the floor plate in the avian embryoQ52114151
Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis.Q52125407
A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tubeQ52133266
The developmental potentials of the caudalmost part of the neural crest are restricted to melanocytes and gliaQ52166655
The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer.Q52169436
Efficient targeting of gene expression in chick embryos by microelectroporation.Q52175897
Developmental biology. Straight and wiggly affinitiesQ52192465
Control of compartmental affinity boundaries by hedgehogQ52559480
Fate mapping the avian epiblast with focal injections of a fluorescent-histochemical marker: ectodermal derivativesQ68538682
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryoQ72051511
Classification scheme for genes expressed during formation and progression of the avian primitive streakQ73421672
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesisQ28588303
Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cellsQ28591758
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent mannerQ28594838
Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning systemQ28750271
A series of normal stages in the development of the chick embryoQ29037347
HNF-3 beta is essential for node and notochord formation in mouse developmentQ29616180
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarityQ29616632
A series of normal stages in the development of the chick embryo. 1951Q29618726
FoxA transcription factors are essential for the development of dorsal axial structuresQ30452527
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tubeQ33885703
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transductionQ34067275
Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizerQ34337070
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron developmentQ34658837
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterningQ34749893
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nucleiQ35102671
Vertebrate floor-plate specification: variations on common themesQ35704419
The floor plate: multiple cells, multiple signalsQ36058430
A simple technique for early in vivo electroporation of E1 chick embryosQ36175823
Classical embryological studies and modern genetic analysis of midbrain and cerebellum developmentQ36294296
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryoQ36769855
Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.Q36914380
Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signalingQ36982676
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor poolsQ37419156
Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneuronesQ37465584
Regulation of limb bud initiation and limb‐type morphologyQ37848308
Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cordQ38302705
HNF-3 beta as a regulator of floor plate developmentQ38312151
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b.Q38314171
A floor plate enhancer of the zebrafish netrin1 gene requires Cyclops (Nodal) signalling and the winged helix transcription factor FoxA2.Q38360484
Regulation of the development of tectal neurons and their projections by transcription factors Brn3a and Pax7.Q38619768
A revised model of Xenopus dorsal midline development: Differential and separable requirements for Notch and Shh signalingQ39788553
Distinct modes of floor plate induction in the chick embryoQ40568568
The spatial and temporal pattern of C-Lmx1 expression in the neuroectoderm during chick neurulationQ40792453
The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell typesQ41710059
Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord.Q41964871
Shh dependent and independent maintenance of basal midbrainQ42451110
Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathwayQ42491392
PAR3 acts as a molecular organizer to define the apical domain of chick neuroepithelial cellsQ42501863
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.Q42734295
Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalonQ43207403
P433issue1
P407language of work or nameEnglishQ1860
P1104number of pages11
P304page(s)32-42
P577publication date2012-06-27
P1433published inDevelopmental BiologyQ3025402
P1476titleA novel role for FOXA2 and SHH in organizing midbrain signaling centers
P478volume369

Reverse relations

cites work (P2860)
Q30612948Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF
Q55090121Cell-cycle-dependent TGFβ-BMP antagonism regulates neural tube closure by modulating tight junctions.
Q33835242Embryonic development of selectively vulnerable neurons in Parkinson's disease.
Q38695143Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line
Q35065419Glycoconjugates distribution during developing mouse spinal cord motor organizers.
Q38100525Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.
Q39223325Nato3 Integrates with the Shh-Foxa2 Transcriptional Network Regulating the Differentiation of Midbrain Dopaminergic Neurons
Q34109406Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells
Q35902185Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion

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