Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

scientific article

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YDBIO.2009.07.006
P698PubMed publication ID19607821
P5875ResearchGate publication ID26675653

P50authorJames BriscoeQ50042910
Martyn GouldingQ94526670
P2093author name stringJeffrey A Whitsett
Nan Gao
Hiroshi Sasaki
Siew-Lan Ang
Klaus H Kaestner
Wei Lin
Nikolaos Balaskas
Emmanouil Metzakopian
Yannis E Mavromatakis
P2860cites workThe foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old ageQ21090191
Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tubeQ24301422
Requirement for Lim1 in head-organizer functionQ24312737
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrainQ28258157
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionQ28291924
Otx2 regulates subtype specification and neurogenesis in the midbrainQ28505456
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterningQ28507384
Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculusQ28508983
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1Q28509262
Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous systemQ28509629
Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2Q28510301
Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neuronsQ28510842
Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain regionQ28511592
A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoterQ28575401
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neuronsQ28587011
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivoQ28588290
Dopamine neuron agenesis in Nurr1-deficient miceQ28589034
Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cellsQ28591758
Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesisQ28593593
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissuesQ28593613
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent mannerQ28594838
Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding siteQ28594955
Cell therapy in Parkinson's diseaseQ33212017
Specification of neuronal identities by feedforward combinatorial codingQ33273615
Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific mannerQ34190470
Sparking new frontiers: using in vivo electroporation for genetic manipulationsQ34229786
Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell developmentQ34382360
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Q34657904
Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanismQ34719625
Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus siteQ36777847
Recent advances in cell-based therapy for Parkinson disease.Q37110252
Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinasesQ39729499
Parkinson's disease. Second of two partsQ40840040
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's diseaseQ41346993
Shh dependent and independent maintenance of basal midbrainQ42451110
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalonQ46344386
Ontogeny of tyrosine hydroxylase mRNA expression in mid- and forebrain: neuromeric pattern and novel positive regions.Q46562616
Identification of intrinsic determinants of midbrain dopamine neuronsQ46913434
Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalonQ48115930
Analysis of the anatomical distribution of GAD67 mRNA encoding truncated glutamic acid decarboxylase proteins in the embryonic rat brainQ48190168
Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants.Q48687878
Gene transfer into cultured mammalian embryos by electroporationQ73816971
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
dopaminergic neuronQ66591220
P304page(s)386-396
P577publication date2009-07-14
P1433published inDevelopmental BiologyQ3025402
P1476titleFoxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development
P478volume333

Reverse relations

cites work (P2860)
Q48265173A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons
Q42283424A novel role for FOXA2 and SHH in organizing midbrain signaling centers
Q35069200An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool
Q38710630BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells
Q97516561Brainstem Organoids From Human Pluripotent Stem Cells
Q38248131Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize
Q38224066Causes and Consequences of MicroRNA Dysregulation in Neurodegenerative Diseases
Q38622890Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b
Q38044388Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy.
Q64232403Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells
Q38256878DICE, an efficient system for iterative genomic editing in human pluripotent stem cells
Q37200879Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells
Q34156273Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.
Q58612523Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons
Q34224069Direct lineage conversions: unnatural but useful?
Q28585909Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate
Q33835242Embryonic development of selectively vulnerable neurons in Parkinson's disease.
Q41769703Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons.
Q37960622FOXA1: a transcription factor with parallel functions in development and cancer.
Q35617128FOXA2 regulates a network of genes involved in critical functions of human intestinal epithelial cells
Q34132210Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell
Q50746233Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
Q37488064Foxa1 is essential for development and functional integrity of the subthalamic nucleus
Q41962839GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons
Q38309820Genetic control of midbrain dopaminergic neuron development.
Q41169511Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells
Q28509973Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors
Q34378485Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells
Q91496388Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors
Q39299435Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L).
Q54397274Hypermethylation-mediated reduction of LMX1A expression in gastric cancer.
Q37739466In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns.
Q26823333Induced pluripotent stem cell technology and direct conversion: new possibilities to study and treat Parkinson's disease
Q41889814Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
Q30665216LMX1B is part of a transcriptional complex with PSPC1 and PSF.
Q37064644Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons
Q39365728Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells
Q48924532Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
Q36170171Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development
Q35674697MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease?
Q37728116MicroRNAs and deregulated gene expression networks in neurodegeneration
Q38100525Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.
Q38234170Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives.
Q39223325Nato3 integrates with the Shh-Foxa2 transcriptional network regulating the differentiation of midbrain dopaminergic neurons
Q36806087Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA
Q34597703Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.
Q94552422Plastrum Testudinis Extracts Promote NSC Differentiation into Dopaminergic Neuron by Regulating the Interaction of TET1 and FoxA2
Q50550801Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.
Q36736908Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain.
Q34109406Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells
Q35902185Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion
Q35078409Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture.
Q50658399Telencephalic neural precursor cells show transient competence to interpret the dopaminergic niche of the embryonic midbrain.
Q38536402Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells
Q93025892The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism
Q37768983The FoxA factors in organogenesis and differentiation
Q28505535The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells
Q37815867The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene
Q34758213The evolution of dopamine systems in chordates
Q55283965The expression of KATP channel subunits in alpha-synuclein-transfected MES23.5 cells.
Q39627175The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide
Q38050536The signaling pathways of LMX1B and its role in glomerulosclerosis
Q36055535Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice
Q34153906Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance
Q47311551Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration
Q92512249Using transcription factors for direct reprogramming of neurons in vitro
Q27692055Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis
Q46296340Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans

Search more.