Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy.

scientific article published on 04 September 2012

Cellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/412040
P932PMC publication ID3441013
P698PubMed publication ID22988464
P5875ResearchGate publication ID230872176

P50authorRosario Sanchez-PernauteQ59677277
Eva HedlundQ39697453
P2093author name stringJulio C Aguila
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A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivoQ28588290
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Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.Q37014769
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Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.Q52223119
Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.Q52249431
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Cell reprogramming gets directQ58951621
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The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathwayQ80418542
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Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalonQ46344386
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.Q46586692
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Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in cultureQ46926584
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisQ47073664
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate.Q48092092
Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease.Q48095855
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Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency.Q48126278
The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's diseaseQ48147372
The substantia nigra of the human brain. I. Nigrosomes and the nigral matrix, a compartmental organization based on calbindin D(28K) immunohistochemistryQ48147383
FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptorsQ48152543
Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetusesQ48165800
Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants.Q48169771
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LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal.Q48472909
The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum.Q48480210
Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon.Q48513133
GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area.Q48709665
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A cytoarchitectonic and chemoarchitectonic analysis of the dopamine cell groups in the substantia nigra, ventral tegmental area, and retrorubral field in the mouse.Q48887515
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.Q48924532
Cell therapeutics in Parkinson's diseaseQ37929026
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Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cellsQ38536402
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.Q39477781
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Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cellsQ39744737
Direct conversion of C. elegans germ cells into specific neuron types.Q40146571
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.Q40216832
Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells.Q40381244
The Role of the Floor Plate in Axon GuidanceQ40441128
The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.Q40462051
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantationQ40493282
TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicityQ40805796
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.Q40876310
Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.Q40942115
Bone morphogenetic proteins: neurotrophic roles for midbrain dopaminergic neurons and implications of astroglial cellsQ41096397
Diversity and pattern in the developing spinal cordQ41191457
Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brainQ41252832
Trophic and protective effects of growth/differentiation factor 5, a member of the transforming growth factor-beta superfamily, on midbrain dopaminergic neuronsQ41264189
TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neuronsQ41431348
Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesisQ41434731
Efficient derivation of functional floor plate tissue from human embryonic stem cellsQ41828883
Midbrain dopaminergic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cellsQ41843416
Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.Q41897447
A critical evaluation of the Braak staging scheme for Parkinson's disease.Q42260364
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Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insultsQ42727069
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.Q42832693
Graft-induced dyskinesias in Parkinson's disease: what is it all about?Q42947830
Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplantsQ42997555
Stem cells and cell replacement therapy for Parkinson's disease.Q43089181
Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalonQ43207403
Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantationQ43218046
Nurr1 is required for maintenance of maturing and adult midbrain dopamine neuronsQ43218195
Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in miceQ43277194
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.Q44037381
Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neuronsQ44408466
Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.Q44451987
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia miceQ44493207
Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo.Q44495486
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Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neuronsQ44796512
Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cellsQ44906339
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriersQ45039594
Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian ratsQ45173532
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.Q45944197
Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis.Q45952942
Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model.Q45981005
Midbrain development induced by FGF8 in the chick embryo.Q46013905
FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F.Q46064927
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degenerationQ33387798
A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cellsQ33492749
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.Q33565361
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.Q33925878
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.Q34010256
Small molecules enable highly efficient neuronal conversion of human fibroblastsQ34031414
Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survivalQ34091038
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian ratsQ34115609
Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson diseaseQ34118080
Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plateQ34140439
Direct conversion of human fibroblasts to dopaminergic neuronsQ34190302
Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression.Q34202895
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factorQ34280164
Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system.Q34319673
Dopaminergic neurons from embryonic mouse mesencephalon are enriched in culture through immunoreaction with monoclonal antibody to neural specific protein 4 and flow cytometryQ34355921
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.Q34416128
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron developmentQ34658837
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine systemQ34761835
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 yearsQ34768147
Anatomical basis of glial cell line-derived neurotrophic factor expression in the striatum and related basal ganglia during postnatal development of the rat.Q34974241
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitorsQ35002960
ES cell-derived renewable and functional midbrain dopaminergic progenitors.Q35034938
Neural transplantation for the treatment of Parkinson's diseaseQ35172255
Functional integration of dopaminergic neurons directly converted from mouse fibroblastsQ35534141
Vertebrate floor-plate specification: variations on common themesQ35704419
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.Q35732928
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.Q35764504
Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigraQ35858546
Visualization, direct isolation, and transplantation of midbrain dopaminergic neuronsQ35947054
Neurotrophic regulation of retinal ganglion cell synaptic connectivity: from axons and dendrites to synapsesQ35959776
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury.Q36243098
Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populationsQ36453736
Calcium, ageing, and neuronal vulnerability in Parkinson's diseaseQ36947731
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P304page(s)412040
P577publication date2012-09-04
P1433published inStem Cells InternationalQ26842114
P1476titleCellular programming and reprogramming: sculpting cell fate for the production of dopamine neurons for cell therapy
P478volume2012

Reverse relations

cites work (P2860)
Q28117378Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons
Q38411899Direct lineage conversion of astrocytes to induced neural stem cells or neurons
Q38218082Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish
Q38129058Nanoparticles based stem cell tracking in regenerative medicine
Q34109406Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells
Q36914272The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson's Disease

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