Three differentiation states risk-stratify bladder cancer into distinct subtypes

scientific article published on 19 January 2012

Three differentiation states risk-stratify bladder cancer into distinct subtypes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PNAS..109.2078V
P8978DBLP publication IDjournals/pnas/VolkmerSCHTKWPC12
P356DOI10.1073/PNAS.1120605109
P932PMC publication ID3277552
P698PubMed publication ID22308455
P5875ResearchGate publication ID221808957

P50authorIrving WeissmanQ884581
Yair LotanQ61862568
A AlizadehQ73440211
Matt van de RijnQ73902580
Theresa A StormQ89520909
Debashis SahooQ89636466
Chad TangQ90237469
Robert Chin-Yao TingQ112066753
Jens-Peter VolkmerQ117277104
Humberto Contreras-TrujilloQ117277105
Linda D ShortliffeQ117277106
P2093author name stringStephen B Willingham
Andrew H Beck
Seth P Lerner
Antonina V Kurtova
Philip Levy Ho
Keith S Chan
Guilherme Godoy
Benjamin I Chung
Senthil K Pazhanisamy
P2860cites workIdentification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cellsQ24657020
Cancer statistics, 2010Q27860525
Stem cells, cancer, and cancer stem cellsQ27860878
Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell developmentQ28513360
Purification and unique properties of mammary epithelial stem cellsQ29616497
A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessmentQ30421675
Gene expression profiling of progressive papillary noninvasive carcinomas of the urinary bladderQ33217204
Bladder cancer initiating cells (BCICs) are among EMA-CD44v6+ subset: novel methods for isolating undetermined cancer stem (initiating) cellsQ33349898
Identification of side population cells from bladder cancer cells by DyeCycle Violet stainingQ33369037
Generation of a concise gene panel for outcome prediction in urinary bladder cancerQ33561596
Cancer stem cells in bladder cancer: a revisited and evolving conceptQ33639897
Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancerQ33650639
MiDReG: a method of mining developmentally regulated genes using Boolean implicationsQ33778561
Everything you wanted to know about the bladder epithelium but were afraid to ask.Q33932620
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like stateQ34178901
Stem cell research: paths to cancer therapies and regenerative medicineQ34452462
Keratin expression in human tissues and neoplasmsQ34636832
Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma.Q34698294
Distinct expression profiles of p63 variants during urothelial development and bladder cancer progressionQ34755858
A four-gene signature predicts disease progression in muscle invasive bladder cancer.Q35017006
Urothelial tumorigenesis: a tale of divergent pathwaysQ36234720
Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancerQ36529700
Boolean implication networks derived from large scale, whole genome microarray datasetsQ37384974
Regional copy number-independent deregulation of transcription in cancerQ40209266
Epidermal differentiation and keratin gene expressionQ40387479
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersQ42457867
Changing patterns of keratin expression could be associated with functional maturation of the developing human bladderQ42523966
Immediate gene expression changes after the first course of neoadjuvant chemotherapy in patients with primary breast cancer diseaseQ45099291
Combined gene expression and genomic profiling define two intrinsic molecular subtypes of urothelial carcinoma and gene signatures for molecular grading and outcome.Q51703160
Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays.Q51955372
Gene Expression Signatures Predict Outcome in Non-Muscle-Invasive Bladder Carcinoma: A Multicenter Validation StudyQ59468822
Epidemiology and etiology of bladder cancerQ73591458
Multicenter validation of a 1,550-gene expression profile for identification of tumor tissue of originQ83583616
P2507corrigendum / erratumCorrection for Volkmer et al., Three differentiation states risk-stratify bladder cancer into distinct subtypesQ93549363
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbladder cancerQ504775
P304page(s)2078-2083
P577publication date2012-01-19
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThree differentiation states risk-stratify bladder cancer into distinct subtypes
P478volume109

Reverse relations

cites work (P2860)
Q90345895A Consensus Molecular Classification of Muscle-invasive Bladder Cancer
Q35072270A cell of origin gene signature indicates human bladder cancer has distinct cellular progenitors
Q34708383ARID1A alterations are associated with FGFR3-wild type, poor-prognosis, urothelial bladder tumors.
Q103836778Advances in bladder cancer biology and therapy
Q42484380Altered expression of CKs 14/20 is an early event in a rat model of multistep bladder carcinogenesis.
Q36878683Androgen receptor expands the population of cancer stem cells in upper urinary tract urothelial cell carcinoma cells
Q90441536Associations between Peripheral Thromboembolic Vascular Disease and Androgen Deprivation Therapy in Asian Prostate Cancer Patients
Q37360092Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers
Q34448168Biomarkers for bladder cancer management: present and future.
Q37053995Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting
Q26771263Bladder Cancer Stem-Like Cells: Their Origin and Therapeutic Perspectives
Q52810295Bladder cancer.
Q42465565Bladder cancers arise from distinct urothelial sub-populations.
Q35735937Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
Q49787389Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer
Q35485418CD14-expressing cancer cells establish the inflammatory and proliferative tumor microenvironment in bladder cancer
Q57452829CD24 regulates cancer stem cell (CSC)-like traits and a panel of CSC-related molecules serves as a non-invasive urinary biomarker for the detection of bladder cancer
Q94547018CK14 Expression Identifies a Basal/Squamous-Like Type of Papillary Non-Muscle-Invasive Upper Tract Urothelial Carcinoma
Q38713728Cancer stem cells in prostate cancer
Q38943219Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy
Q97074381Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A-GATA3-STAT3 Circuit
Q41160701Claudin-low bladder tumors are immune infiltrated and actively immune suppressed
Q89997628Clinical outcomes of muscle invasive bladder Cancer according to the BASQ classification
Q47777684Clinicopathologic and Immunohistochemical Study of Combined Small Cell Carcinoma and Urothelial Carcinoma Molecular Subtype
Q37215956Constitutive β-catenin activation induces male-specific tumorigenesis in the bladder urothelium
Q47551371Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis
Q92812554Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer
Q95321930Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers
Q93039546Evaluation of PD-L1 and other immune markers in bladder urothelial carcinoma stratified by histologic variants and molecular subtypes
Q36882005FGFR3b Extracellular Loop Mutation Lacks Tumorigenicity In Vivo but Collaborates with p53/pRB Deficiency to Induce High-grade Papillary Urothelial Carcinoma
Q36546605Functional and molecular characterization of cancer stem-like cells in bladder cancer: a potential signature for muscle-invasive tumors.
Q40835446Genome-Wide Scan for Methylation Profiles in Keloids
Q92783364Hyper-Activation of STAT3 Sustains Progression of Non-Papillary Basal-Type Bladder Cancer via FOSL1 Regulome
Q93068067Identification of gene expression logical invariants in Arabidopsis
Q49473929Immune Responses to Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer.
Q33817493Immunohistochemiocal subtyping using CK20 and CK5 can identify urothelial carcinomas of the upper urinary tract with a poor prognosis
Q39028041In stage pT1 non-muscle-invasive bladder cancer (NMIBC), high KRT20 and low KRT5 mRNA expression identify the luminal subtype and predict recurrence and survival
Q92135391Increased expression of TRIP13 drives the tumorigenesis of bladder cancer in association with the EGFR signaling pathway
Q41339763Insights from animal models of bladder cancer: recent advances, challenges, and opportunities
Q104495363Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy
Q28088334Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise
Q37024540KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis
Q92826166Keratin-14 (KRT14) Positive Leader Cells Mediate Mesothelial Clearance and Invasion by Ovarian Cancer Cells
Q34433060LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types
Q35568071Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer
Q92659257Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells
Q37317523Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis
Q35285703Modelling bladder cancer in mice: opportunities and challenges
Q57175925Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy
Q38297729Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
Q26744343Molecular substratification of bladder cancer: moving towards individualized patient management
Q35640830Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems
Q36217643Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin
Q37358942Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.
Q26825948Normal and neoplastic urothelial stem cells: getting to the root of the problem
Q34670535Novel neoadjuvant therapy paradigms for bladder cancer: results from the National Cancer Center Institute Forum
Q35612218Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas
Q39459198Pharmacogenomic considerations in the treatment of muscle-invasive bladder cancer
Q38816754Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines
Q37696186Positive association of collagen type I with non-muscle invasive bladder cancer progression
Q38424919Potential role for targeted therapy in muscle-invasive bladder cancer: lessons from the cancer genome atlas and beyond.
Q90617471Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
Q47406496Precision medicine for urothelial bladder cancer: update on tumour genomics and immunotherapy
Q92046407Predictive value of phenotypic signatures of bladder cancer response to cisplatin-based neoadjuvant chemotherapy
Q47727562Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas
Q35730347Quantitative Analysis of Differential Proteome Expression in Bladder Cancer vs. Normal Bladder Cells Using SILAC Method
Q38693644Role of Sonic Hedgehog (Shh) Signaling in Bladder Cancer Stemness and Tumorigenesis
Q28080330Role of angiogenesis in urothelial bladder carcinoma
Q90469821SIU-ICUD consultation on bladder cancer: basic science
Q41233576Sequencing of cancer cell subpopulations identifies micrometastases in a bladder cancer patient
Q42515074Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases
Q34505763Side population in human non-muscle invasive bladder cancer enriches for cancer stem cells that are maintained by MAPK signalling
Q42503789Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration
Q42275760Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer
Q57171093Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4
Q50000734Subtyping Bladder Cancers: Biology vs Bioinformatics
Q38902594Synergy of Histone-Deacetylase Inhibitor AR-42 with Cisplatin in Bladder Cancer.
Q95785557The Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer
Q91653506The functional potency of natural killer cells in response to IL-2/IL-15/IL-21 stimulation is limited by a concurrent upregulation of Tim-3 in bladder cancer
Q35683471The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells
Q36579525The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205.
Q36193716The power of boolean implication networks
Q38202644The relationship of cancer stem cells in urological cancers
Q99233211The value and limitations of urothelial bladder carcinoma molecular classifications to predict oncological outcomes and cancer treatment response: A systematic review and meta-analysis
Q64062159Therapeutic Targeting of Collective Invasion in Ovarian Cancer
Q64274457Transcriptional Analysis of Immunohistochemically Defined Subgroups of Non-Muscle-Invasive Papillary High-Grade Upper Tract Urothelial Carcinoma
Q95661266Transcriptional profiling of lung macrophages identifies a predictive signature for inflammatory lung disease in preterm infants
Q55126311Understanding the biology of urothelial cancer metastasis.
Q36150692Update on The Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer
Q89639841UroSEEK gene panel for bladder cancer surveillance
Q42514824Urothelial Carcinoma Stem Cells: Current Concepts, Controversies, and Methods.
Q39097235Urothelial generation and regeneration in development, injury, and cancer.
Q90339620Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
Q97518464lncRNA SNHG1 Promotes Basal Bladder Cancer Invasion via Interaction with PP2A Catalytic Subunit and Induction of Autophagy
Q91761018β-Arrestins Regulate Stem Cell-Like Phenotype and Response to Chemotherapy in Bladder Cancer

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