COX-2 inhibition in cancer therapeutics: a field of controversy or a magic bullet?

scientific article published on April 2004

COX-2 inhibition in cancer therapeutics: a field of controversy or a magic bullet? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/13543784.13.4.359
P698PubMed publication ID15102586

P2093author name stringAthanasios G Papavassiliou
Michalis V Karamouzis
P2860cites workCyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?Q24536027
Gleevec (STI-571) inhibits lung cancer cell growth (A549) and potentiates the cisplatin effect in vitroQ24799983
Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study GroupQ28138338
Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemopreventionQ28193249
Induction of the CBP transcriptional co-activator early during laryngeal carcinogenesis.Q53391057
Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients.Q53961800
A randomized trial of aspirin to prevent colorectal adenomasQ28195296
Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junctionQ28215716
Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2Q28573372
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposisQ29616121
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety StudyQ29620671
Carcinogen substrate specificity of human COX-1 and COX-2.Q31835278
Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II studyQ33348167
Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesisQ33834295
Rofecoxib reduces polyp recurrence in familial polyposisQ33974041
The coxibs, selective inhibitors of cyclooxygenase-2.Q34086325
Redefining the target: chemotherapeutics as antiangiogenicsQ34142103
Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesisQ34156486
Many actions of cyclooxygenase-2 in cellular dynamics and in cancerQ34539982
COX-2 inhibitors in cancer treatment and prevention, a recent developmentQ34568813
The role of cyclooxygenase inhibitors in cancer preventionQ34595366
A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposisQ34637596
Angiogenic markers, neovascularization and malignant deformation of Barrett's esophagus.Q34680750
Linkage between retinoid and fatty acid receptors: implications for breast cancer preventionQ34796087
Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancerQ34804039
Current concepts in cyclooxygenase inhibition in breast cancerQ34969789
Cyclooxygenase 2 selective inhibitors in cancer treatment and preventionQ35011895
Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapyQ35033434
Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatmentQ35043366
Cyclooxygenase 2: a molecular target for cancer prevention and treatmentQ35057356
Prostate cancer: horizons in the development of novel anti-cancer strategiesQ35100605
Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: a reviewQ35138602
Valdecoxib: a reviewQ35174224
COX-2 selective inhibitors: analysis of the renal effectsQ35194538
Hepatocellular carcinoma: is there a potential for chemoprevention using cyclooxygenase-2 inhibitors?Q35196709
Cyclo-oxygenase 2 inhibition in colorectal cancer therapyQ35208078
Channelling bias and the incidence of gastrointestinal haemorrhage in users of meloxicam, coxibs, and older, non-specific non-steroidal anti-inflammatory drugs.Q35595971
Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathwaysQ40880153
The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activityQ44300952
Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activationQ44327392
Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gammaQ44392696
Celecoxib, a selective cyclo-oxygenase-2 inhibitor, enhances the response to preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancerQ44513206
Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibitionQ44582774
Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer: preliminary reportQ44659442
Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus.Q53376153
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)359-372
P577publication date2004-04-01
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleCOX-2 inhibition in cancer therapeutics: a field of controversy or a magic bullet?
P478volume13

Reverse relations

cites work (P2860)
Q91974677COX-2 as a potential biomarker and therapeutic target in melanoma
Q40233446Expression of cyclooxygenase-2 mRNA in peripheral blood of head and neck cancer patients and in healthy controls. A pilot study.
Q36764481Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis
Q39640869Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production
Q34234484The long-acting COX-2 inhibitor mavacoxib (Trocoxilâ„¢) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro
Q57703131Therapeutic use of HMG-CoA reductase inhibitors: current practice and future perspectives
Q90542917siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease
Q94076162siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease

Search more.