The weight of leptin in immunity

scientific article published on May 2004

The weight of leptin in immunity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1033571944
P356DOI10.1038/NRI1350
P698PubMed publication ID15122202

P2093author name stringGiuseppe Matarese
Antonio La Cava
P2860cites workPositional cloning of the mouse obese gene and its human homologueQ22251285
Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathwayQ24291751
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob miceQ24563099
Crystal structure of the obese protein leptin-E100Q27737094
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptinQ28115346
Expression of leptin receptors and response to leptin stimulation of human natural killer cell linesQ28115570
Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitroQ28115650
PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestineQ28364469
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone massQ28505908
The leptin receptorQ28509967
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppressionQ28594263
Leptin and the regulation of body weight in mammalsQ29615976
Identification and expression cloning of a leptin receptor, OB-RQ29620255
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitisQ29620481
Calorie restriction prevents the occlusive coronary vascular disease of autoimmune (NZW x BXSB)F1 miceQ33492697
A role for leptin and its cognate receptor in hematopoiesisQ34396970
Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of actionQ34489760
The CD28 signaling pathway regulates glucose metabolismQ34525357
Nutrition and diet in the clinical management of multiple sclerosisQ34572682
Leptin signallingQ34646543
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.Q34785785
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responsesQ34830426
Lymphocide: cytokines and the control of lymphoid homeostasisQ34988349
Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axisQ35006423
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.Q35056090
Leptin-deficient mice are protected from accelerated nephrotoxic nephritisQ35083473
Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of actionQ35161166
Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposityQ35223081
Leptin consumption in the inflamed joints of patients with rheumatoid arthritisQ35552048
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expressionQ36266492
Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexiaQ36376685
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamstersQ37354703
Calories versus protein in onset of renal disease in NZB x NZW miceQ37392952
Leptin: a pivotal mediator of intestinal inflammation in miceQ38288331
Leptin deficiency, not obesity, protects mice from Con A-induced hepatitisQ38292343
Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritisQ38293245
High-dose leptin activates human leukocytes via receptor expression on monocytes.Q38295956
Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.Q38301009
Thyroid hormones influence serum leptin levels in patients with Graves' disease during suppression of beta-adrenergic receptorsQ38307959
Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis.Q38323455
Biological action of leptin as an angiogenic factorQ38333557
Leptin indirectly activates human neutrophils via induction of TNF-alphaQ38345760
The intricate interplay among body weight, stress, and the immune response to friend or foe.Q39741042
Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE.Q40729024
Activation of downstream signals by the long form of the leptin receptorQ40881831
Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2.Q40908774
Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activationQ42527523
Divergent roles of SHP-2 in ERK activation by leptin receptorsQ43510196
Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis.Q43587345
Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: possible role of Sam68.Q43827252
Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumoniaQ43950679
Leptin inhibits stress-induced apoptosis of T lymphocytesQ43975329
Endotoxin stimulates leptin in the human and nonhuman primate.Q44357262
Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathwayQ44376057
Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanismQ44582397
Leptin Regulates Functional Capacities of Polymorphonuclear NeutrophilsQ44623929
Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinemia in ratsQ45889032
Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock.Q46356276
Anti-TNF-α Antibody Normalizes Serum Leptin in IL-2 Deficient MiceQ48576491
Immunology: Fast and feel good?Q48603483
Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro.Q48612749
Serum leptin in children and young adults with inflammatory bowel disease.Q50888980
Serum leptin levels in patients with nonalcoholic steatohepatitis.Q51551654
Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation.Q51560361
Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans.Q52184774
The bioenergetics of the immune system.Q52588037
Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression.Q53934175
Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males.Q54001341
Serum leptin levels and their relationship to tumor necrosis factor-alpha and interleukin-6 in neonatal sepsis.Q54512549
Chemokines control fat accumulation and leptin secretion by cultured human adipocytesQ57076426
Leptin Signaling in Human Peripheral Blood Mononuclear Cells, Activation of p38 and p42/44 Mitogen-Activated Protein (MAP) Kinase and p70 S6 KinaseQ63916243
Effects of calorie restriction on transforming growth factor beta 1 and proinflammatory cytokines in murine Sjogren's syndromeQ71731047
Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary diseaseQ73047125
Nutrition in inflammatory bowel diseaseQ73252653
Leptin as a marker of multiple sclerosis activity in patients treated with interferon-betaQ73508033
Elevated leptin levels are associated with excess gains in fat mass in girls, but not boys, with type 1 diabetes: longitudinal study during adolescenceQ73586750
Serum leptin levels in neonatal bacterial septicemiaQ73706289
Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activityQ74601114
High leptin levels in women developing postpartum thyroiditisQ75270289
Circulating leptin in patients with chronic obstructive pulmonary diseaseQ77293107
Balancing susceptibility to infection and autoimmunity: a role for leptin?Q77846188
Leptin accelerates autoimmune diabetes in female NOD miceQ78014683
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)371-379
P577publication date2004-05-01
P1433published inNature Reviews ImmunologyQ43355
P1476titleThe weight of leptin in immunity
P478volume4

Reverse relations

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Q35495099Role of transcription factor modifications in the pathogenesis of insulin resistance.
Q26991808SOCS, inflammation, and cancer
Q51758245Salivary and serum leptin concentrations in patients with chronic periodontitis.
Q38265681Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?
Q38827186Sebocytes differentially express and secrete adipokines
Q48944298Selection of non-competitive leptin antagonists using a random nanobody-based approach
Q36653699Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia
Q90694520Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model
Q38331523Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions
Q33990765Short-term re-feeding of previously energy-restricted C57BL/6 male mice restores body weight and body fat and attenuates the decline in natural killer cell function after primary influenza infection
Q24816719Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1
Q40142299Significantly enhanced lung metastasis and reduced organ NK cell functions in diet-induced obese rats.
Q24301625Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity
Q22337448Sleep and immune function
Q33695185Soluble Factors on Stage to Direct Mesenchymal Stem Cells Fate.
Q51356360Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity.
Q82570577Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury
Q34920980T regulatory lymphocytes and endothelial function in pediatric obstructive sleep apnea
Q49958603Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.
Q38074174Targeting IL-1 in Sjögren's syndrome.
Q26798273The "Big Bang" in obese fat: Events initiating obesity-induced adipose tissue inflammation
Q57287918The 10,000 Immunomes Project: Building a Resource for Human Immunology
Q37389738The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women
Q90072442The Gut Microbiota in Multiple Sclerosis: An Overview of Clinical Trials
Q33653828The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease
Q37815355The burden of obesity on infectious disease
Q36177659The effect of enteral nutrition on adipokines in patients with acute pancreatitis
Q43053740The effects of dexketoprofen on endogenous leptin and lipid peroxidation during liver ischemia reperfusion injury.
Q46859434The effects of obesity and fatty acids on the feline immune system
Q50937920The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index.
Q37439386The emerging role of the endocannabinoid system in cardiovascular disease
Q30414240The impact of obesity on the immune response to infection
Q45202664The influence of reproductive physiology and nutrient supply on the periparturient relaxation of immunity to the gastrointestinal nematode Trichostrongylus colubriformis in Merino ewes.
Q24646258The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling
Q37915059The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes
Q37190733The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?
Q37004969The methylation of the LEPR/LEPROT genotype at the promoter and body regions influence concentrations of leptin in girls and BMI at age 18 years if their mother smoked during pregnancy
Q28392224The potential interplay of adipokines with toll-like receptors in the development of hepatocellular carcinoma
Q26852901The role of adipokines in chronic inflammation
Q35940078The role of immune tolerance in preventing and treating arthritis
Q38637700The role of infiltrating immune cells in dysfunctional adipose tissue.
Q49087290The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease
Q47967427The role of leptin as a biomarker in the relationship between periodontitis and chronic migraine.
Q37625593The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury.
Q37143578The role of the endocannabinoid system in atherosclerosis.
Q33847366The vagus nerve and the inflammatory reflex--linking immunity and metabolism
Q36234687Time Course of Leptin in Patients with Anorexia Nervosa during Inpatient Treatment: Longitudinal Relationships to BMI and Psychological Factors
Q55009518Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology.
Q36510376Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines
Q52659223Upregulated Leptin in Periodontitis Promotes Inflammatory Cytokine Expression in Periodontal Ligament Cells.
Q98205091Using proximity extension proteomics assay to discover novel biomarkers associated with circulating leptin levels in patients with type 2 diabetes
Q45979569Variation in plasma leptin-like immunoreactivity in free-living European starlings (Sturnus vulgaris).
Q39148616Visceral Adiposity, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.
Q24597924What are We Learning and What Can We Learn from the Human Oral Microbiome Project?
Q34983471What does irritable bowel syndrome share with non-alcoholic fatty liver disease?
Q37405131What have we really learned about macrophage recruitment to adipose tissue?
Q58698517What is the role of adipokines in myasthenia gravis?
Q36926274Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet

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