Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease

scientific article published on December 2014

Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3109/09273948.2014.986581
P8608Fatcat IDrelease_ogy7fq4uibhjje5gunf3mwv5fe
P932PMC publication ID4478284
P698PubMed publication ID25535823

P2093author name stringMarjan Farid
Anthony B Nesburn
Lbachir BenMohamed
Anshu Agrawal
Jeremiah Tao
Daniel Fremgen
He Chuyi
P2860cites workImpact of ocular surface symptoms on quality of life in a United States Veterans Affairs populationQ24169749
Depression, post-traumatic stress disorder, and dry eye syndrome: a study utilizing the national United States Veterans Affairs administrative databaseQ24169750
Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitisQ24814121
The role of caspase cascade on the development of primary Sjögren's syndromeQ28182370
Prevalence of dry eye syndrome among US womenQ28196875
Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eyeQ28214408
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseasesQ28241769
Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10Q28247155
Hormonal regulatory influence in tear filmQ28293797
Review: systemic absorption of topically applied ocular drugs in humansQ28332826
Altered distribution of aquaporin 5 and its C-terminal binding protein in the lacrimal glands of a mouse model for Sjögren's syndromeQ28505174
NK cells promote Th-17 mediated corneal barrier disruption in dry eyeQ28730069
Influence des hormones sur le film lacrymalQ29999898
Effect of desiccating stress on mouse meibomian gland function.Q30422074
Ocular biocompatibility of novel Cyclosporin A formulations based on methoxy poly(ethylene glycol)-hexylsubstituted poly(lactide) micelle carriersQ30995647
Lacrimal drainage-associated lymphoid tissue (LDALT): a part of the human mucosal immune system.Q32061864
M cells in the follicle-associated epithelium of the rabbit conjunctiva preferentially bind and translocate latex beadsQ33225980
A new model of experimental autoimmune keratoconjunctivitis sicca (KCS) induced in Lewis rat by the autoantigen Klk1b22.Q33390308
Prevalence of dry eye disease among US men: estimates from the Physicians' Health StudiesQ33720070
Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunizationQ33725145
Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis.Q33727906
Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammationQ33769533
Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3.Q33771577
An autoimmune response to odorant binding protein 1a is associated with dry eye in the Aire-deficient mouseQ33776473
Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbitsQ33784381
Neurologic evaluation of acute lacrimomimetic effect of cyclosporine in an experimental rabbit dry eye modelQ33793715
IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjögren's syndrome-like disease of the nonobese diabetic mouseQ33795156
Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: the Beaver Dam Eye StudyQ33824902
M cell-targeted ocular immunization: effect on immunoglobulins in tears, feces, and serum.Q33845253
Reducing peak corneal haze after photorefractive keratectomy in rabbits: prednisolone acetate 1.00% versus cyclosporine A 0.05%Q33846813
[Eye-associated lymphoid tissue (EALT) is continuously spread throughout the ocular surface from the lacrimal gland to the lacrimal drainage system]Q79359962
Corneal antigen presentation: molecular regulation and functional implicationsQ79537130
Protective effect of uridine on cornea in a rabbit dry eye modelQ79837302
Evaluation of ocular surface changes in a rabbit dry eye model using a modified impression cytology techniqueQ80204638
The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Q80347907
The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)Q80347909
Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007)Q80347912
Design and conduct of clinical trials: report of the Clinical Trials Subcommittee of the International Dry Eye WorkShop (2007)Q80347916
Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007)Q80347919
Research in dry eye: report of the Research Subcommittee of the International Dry Eye WorkShop (2007)Q80347923
Abnormal keratocytes and stromal inflammation in chronic phase of severe ocular surface diseases with stem cell deficiencyQ80530977
The economic burden of dry eye: a conceptual framework and preliminary assessmentQ80902614
FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides to enhance T-cell and natural killer cell functionQ81213577
Ultrastructural anatomy of CALT follicles in the rabbit reveals characteristics of M-cells, germinal centres and high endothelial venulesQ81277517
[Lacrimal gland-associated mucins. Age related production and their role in the pathophysiology of dry eye]Q81335105
Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyesQ81357274
Nasal-associated lymphoid tissue is not an absolute requirement for the induction of rat tear IgA antibody responsesQ82289708
Factors affecting evaporation rates of tear film components measured in vitroQ83150549
A novel cyclosporin a aqueous formulation for dry eye treatment: in vitro and in vivo evaluationQ83684549
Novel micelle carriers for cyclosporin A topical ocular delivery: in vivo cornea penetration, ocular distribution and efficacy studiesQ83738252
Elevated nerve growth factor in dry eye associated with established contact lens wearQ84388777
[Inflammaging. Aging inflammatory origin]Q84765696
CD3 mAb treatment ameliorated the severity of the cGVHD-induced lupus nephritis in mice by up-regulation of Foxp3+ regulatory T cells in the target tissue: kidneyQ85046829
New insight into dry eye inflammationQ85715473
Expansion of CD4+CD25-GITR+ regulatory T-cell subset in the peripheral blood of patients with primary Sjögren's syndrome: correlation with disease activityQ85749208
Regulatory T cells in the prevention of mucosal inflammatory diseases: patrolling the borderQ36949181
The influence of sex steroids on Sjögren's syndromeQ36951058
Spdef null mice lack conjunctival goblet cells and provide a model of dry eye.Q36986476
Elevation of conjunctival epithelial CD45INTCD11b⁺CD16⁺CD14⁻ neutrophils in ocular Stevens-Johnson syndrome and toxic epidermal necrolysis.Q37012774
Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye diseaseQ37013881
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppressionQ37071969
A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpesQ37118262
Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathyQ37129577
Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye.Q37139290
Functional anatomy and immunological interactions of ocular surface and adnexaQ37153414
Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease.Q37195776
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cellsQ37216199
Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sjögren's syndrome-associated dry eye.Q37238671
The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca.Q37257746
Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbitQ37258314
Corneal epithelial proliferation and thickness in a mouse model of dry eye.Q37269968
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient miceQ37316518
The interaction between gut microbiota and age-related changes in immune function and inflammation.Q37359975
T helper cytokines in dry eye diseaseQ37374838
New concepts in herpes simplex virus vaccine development: notes from the battlefieldQ37384857
CD8⁺ cells regulate the T helper-17 response in an experimental murine model of Sjögren syndromeQ37407580
Rationale for anti-inflammatory therapy in dry eye syndromeQ37410903
Type III IFNs: new layers of complexity in innate antiviral immunityQ37423226
New horizon of mucosal immunity and vaccinesQ37506786
Identifying an appropriate animal model for the nasolacrimal drainage systemQ37645940
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?Q37682005
Dry eye in the beaver dam offspring study: prevalence, risk factors, and health-related quality of lifeQ37715859
Toll-like receptors in ocular surface diseaseQ37719810
Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches.Q37730124
Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT).Q37760696
Impact of aging on dendritic cell functions in humansQ37771485
A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human.Q37780303
Colloidal systems for the delivery of cyclosporin A to the anterior segment of the eye.Q37858088
Sex steroids in Sjögren's syndrome.Q37980936
Postherpetic lacrimal obstructionQ33860062
Age-related differences in heat loss capacity occur under both dry and humid heat stress conditionsQ33912854
Prevalence and risk factors of dry eye syndrome in a United States veterans affairs populationQ33964406
Immune response to chlamydial 60-kilodalton heat shock protein in tears from Nepali trachoma patientsQ34008628
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO miceQ34019278
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseasesQ34040980
Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis siccaQ34110644
The economic burden of dry eye disease in the United States: a decision tree analysisQ34147677
Review of the diagnosis and management of acquired nasolacrimal duct obstructionQ34177553
Research on the stability of a rabbit dry eye model induced by topical application of the preservative benzalkonium chlorideQ34206447
Aging and dry eye diseaseQ34273593
Effect of inflammation on lacrimal gland function.Q34338027
Dry Eye Disease: Impact on Quality of Life and VisionQ34346990
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady stateQ34381360
c-Jun NH2-terminal kinase mediates interleukin-1beta-induced inhibition of lacrimal gland secretion.Q34481014
Effectiveness of artificial tears in the management of evaporative dry eye.Q34632803
Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical studyQ34646906
CD3-specific antibodies: a portal to the treatment of autoimmunityQ34654024
Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitisQ34735468
The conjunctival lymphoid follicle in mucosal immunologyQ34776561
Effects of age and dysfunction on human meibomian glands.Q34919583
Evidence of corneal lymphangiogenesis in dry eye disease: a potential link to adaptive immunity?Q34952967
Establishment of the mild, moderate and severe dry eye models using three methods in rabbitsQ35008077
Effect of subconjunctival lacrimal gland transplantation in a rabbit dry eye modelQ35012030
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responsesQ35027578
Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye diseaseQ35040958
Role of immunity and inflammation in corneal and ocular surface disease associated with dry eye.Q35076462
The human nasolacrimal ductsQ35088446
Apoptosis and Sjögren syndromeQ35200715
Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunityQ35201154
GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in miceQ35484886
Molecular mechanisms of immunity in corneal allotransplantation and xenotransplantationQ35571083
Mechanisms involved in injury and repair of the murine lacrimal gland: role of programmed cell death and mesenchymal stem cellsQ35575645
CD3 antibody treatment stimulates the functional capability of regulatory T cellsQ35580439
A single injection of interleukin-1 induces reversible aqueous-tear deficiency, lacrimal gland inflammation, and acinar and ductal cell proliferationQ35602641
Exposure to a controlled adverse environment impairs the ocular surface of subjects with minimally symptomatic dry eye.Q50681036
Mycobacterium bovis bacillus Calmette-Guérin killed by extended freeze-drying targets plasmacytoid dendritic cells to regulate lung inflammation.Q50716084
Establishment of a rabbit short-term dry eye model.Q50765301
Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis.Q50994458
TEARS AND THE LACRIMAL GLAND.Q51269954
Tear film evaporation--effect of age and gender.Q51775156
In vivo adjuvant effect of interleukins 5 and 6 on rat tear IgA antibody responses.Q52098735
Tear evaporation from the ocular surface.Q52414577
Influence of the eye-associated lymphoid tissue (EALT) on inflammatory ocular surface disease.Q52928043
Dry-eye--is inflammation just the tip of the iceberg?Q53119440
Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice.Q53362260
Effect of flurbiprofen on herpes simplex keratitis in rabbits.Q53995597
Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing.Q54297363
Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease.Q54301170
Analysis of inflammatory cytokines in the tears of dry eye patients.Q54467014
Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyesQ57693415
Dry Eye–Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-γQ61851323
Desiccating Stress Induces T Cell-Mediated Sjogren's Syndrome-Like Lacrimal KeratoconjunctivitisQ61851332
Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival diseaseQ62116773
Two-way traffic on the bridge from innate to adaptive immunity.Q64974171
Antibody production in rats following ocular-topical or gastrointestinal immunization: kinetics of local and systemic antibody productionQ68096932
Effects of eyelid closure and nasolacrimal duct occlusion on the systemic absorption of ocular timolol in human subjectsQ68840566
Effect of punctal occlusion by Freeman silicone plug insertion on tear osmolarity in dry eye disordersQ69098768
Studies on the origin and composition of IgA in rat tearsQ69446283
Comparative effects of scopolamine and atropine in preventing cholinesterase inhibitor induced lethalityQ69976127
Ocular surface upregulation of intercellular adhesive molecule-1 (ICAM-1) by local interferon-gamma (IFN-gamma) in the ratQ71160997
The effect of immunization route and sequence of stimulation on the induction of IgA antibodies in tearsQ71389488
Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry/wet combination autoinjectors containing HI 6 or HLö 7Q71644000
Effect of age on human tear film evaporation in normalsQ72058955
Secretory component of IgA: a marker for differentiation of ocular epitheliumQ72625011
Preservation of corneal integrity by the mucin secretagogue 15(S)-HETE in a rabbit model of desiccation-induced dry eyeQ73071779
Localization and characterization of immunocompetent cells in the human retinaQ73306166
Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified miceQ73336126
Dissociation of allergen-specific IgE and IgA responses in sera and tears of pollen-allergic patients: a study performed with purified recombinant pollen allergensQ73651183
Closed chamber thermometry and humidity measurements in normal and dry eye patients: a pilot studyQ73693564
Conjunctiva-associated lymphoid tissue in the human eyeQ73751782
IgA antibodies to Toxoplasma gondii in human tearsQ74150883
Demonstration and organization of duct-associated lymphoid tissue (DALT) of the main excretory duct in the monkey parotid glandQ74226323
Inductive pathways leading to rat tear IgA antibody responsesQ74525500
Enhancement of rat tear IgA antibody responses following intranasal immunization with antigen and CpG ODNQ74765096
Inflammation: a unifying theory for the origin of dry eye syndromeQ75260274
The acinar and ductal organisation of the tarsal accessory lacrimal gland of Wolfring in rabbit eyelidQ77229489
Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutesQ77389467
Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency?Q77425439
Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjögren's syndromeQ77459072
Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitisQ78720584
Role of the gut microbiota in age-related chronic inflammation.Q38047065
New agents for treating dry eye syndrome.Q38058002
Allergic disorders at a venerable age: a mini-review.Q38170986
Tumor necrosis factor alpha induces Warburg-like metabolism and is reversed by anti-inflammatory curcumin in breast epithelial cellsQ39153893
Characterization of a new regulatory CD4+ T cell subset in primary Sjögren's syndromeQ39418862
Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbitsQ39540942
Duct-associated lymphoid tissue (DALT) of minor salivary glands and mucosal immunity.Q39728088
Live conjunctiva-associated lymphoid tissue analysis in rabbit under inflammatory stimuli using in vivo confocal microscopy.Q39936429
Movement of internal canalicular orifice in association with blinking: direct observation after dacryocystorhinostomyQ40132778
Conjunctival cytokine expression in symptomatic moderate dry eye subjectsQ40275692
Measurement of IgG, IgM and IgA concentrations in canine serum, saliva, tears and bile.Q40851681
Unique characteristics of lacrimal glands as a part of mucosal immune network: high frequency of IgA-committed B-1 cells and NK1.1+ alphabeta T cells.Q40906380
Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells.Q41113233
Differential diagnosis of dry eye conditionsQ41231731
Airway epithelium as an effector of inflammation: molecular regulation of secondary mediatorsQ41602396
Prolactin and prolactin receptors in the lacrimal glandQ41683469
Proliferation of lacrimal gland acinar cells in primary culture. Stimulation by extracellular matrix, EGF, and DHT.Q41743744
Deletion of the chemokine receptor CCR1 prolongs corneal allograft survivalQ41765008
Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditisQ42103691
Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD).Q42160497
A rabbit dry eye model induced by topical medication of a preservative benzalkonium chlorideQ42435289
Secretion of proinflammatory cytokines by human conjunctival epithelial cellsQ42441794
Cytopathology and exocrine dysfunction induced in ex vivo rabbit lacrimal gland acinar cell models by chronic exposure to histamine or serotoninQ42451469
Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation.Q42469533
Interacting influences of pregnancy and corneal injury on rabbit lacrimal gland immunoarchitecture and functionQ42492611
Apical and basal-lateral Na/K-ATPase in rat lacrimal gland acinar cellsQ42508718
Comparative effects of topical ocular anti-allergy drugs on human conjunctival mast cellsQ42545586
Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivoQ42821897
Synthesis and anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophagesQ42863514
Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndromeQ42940964
Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumoniaQ42948319
Mesenchymal cells from limbal stroma of human eye.Q43078003
The antiviral resistance and replication of cidofovir-resistant adenovirus variants in the New Zealand White rabbit ocular model.Q43657411
Effect of humidity variations in a controlled environment chamber on tear evaporation after dry eye therapyQ43716454
Analysis of tear cytokines and clinical correlations in Sjögren syndrome dry eye patients and non-Sjögren syndrome dry eye patientsQ43805073
INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye modelQ44131963
Androgen control of gene expression in the rabbit meibomian gland.Q44339203
Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction.Q44339260
Intragraft mechanisms associated with the immunosuppressive versus the tolerogenic effect of CD3 antibodies in a mouse model of islet allografts.Q44465299
Systematic variations in immune response-related gene transcript abundance suggest new questions about environmental influences on lacrimal gland immunoregulationQ44492211
Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microgliaQ44666530
ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr miceQ44809776
CD4(+) CD25(low) GITR(+) cells: a novel human CD4(+) T-cell population with regulatory activity.Q45127836
Clinical and cytologic characteristics of allergic rhinitis in elderly patientsQ45368516
Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvantQ45534569
Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus-1 infectionQ45730979
Therapeutic periocular vaccination with a subunit vaccine induces higher levels of herpes simplex virus-specific tear secretory immunoglobulin A than systemic vaccination and provides protection against recurrent spontaneous ocular shedding of virusQ45752045
A therapeutic vaccine that reduces recurrent herpes simplex virus type 1 corneal disease.Q45755659
Mucosal immunity and self-tolerance in the ocular surface systemQ46074525
Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions.Q46080871
Immunogold localization of prolactin in acinar cells of lacrimal glandQ46080937
Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccinesQ46184452
Adenovirus infection of the cornea causes histopathologic changes in the lacrimal glandQ46336785
Inflammation in dry eye.Q46372528
Preservation of tear film integrity and inhibition of corneal injury by dexamethasone in a rabbit model of lacrimal gland inflammation-induced dry eye.Q46460231
In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammationQ46460388
The controlled-environment chamber: a new mouse model of dry eye.Q46618772
Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cellsQ46904608
Assessment of vision-related quality of life in dry eye patients.Q47335465
Tear film aberration dynamics and vision-related quality of life in patients with dry eye diseaseQ47755532
Effect of tear secretory IgA on chemotaxis of polymorphonuclear leucocytesQ47763267
Intestinal microflora and diversification of the rabbit antibody repertoireQ47840264
Pharmacological prevention of radiation-induced dry eye-an experimental study in a rabbit model.Q48619166
Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome.Q48883243
Nasal-associated lymphoid tissue is an inductive site for rat tear IgA antibody responses.Q50194063
Lactoferrin suppresses loss of corneal epithelial integrity in a rabbit short-term dry eye model.Q50524496
Regulatory pathways in lacrimal gland epitheliumQ35624258
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatmentQ35748567
Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cellsQ35791588
Developing an asymptomatic mucosal herpes vaccine: the present and the futureQ35881975
Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye diseaseQ35907009
Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.Q35914558
Tear film and ocular surface tests in animal models of dry eye: uses and limitationsQ35925823
The role of eye-associated lymphoid tissue in corneal immune protectionQ36055621
Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiencyQ36120878
Toll-like receptor expression and activation in mice with experimental dry eye.Q36159551
Ocular safety of cationic emulsion of cyclosporine in an in vitro corneal wound-healing model and an acute in vivo rabbit modelQ36182937
The role of nasopharyngeal lymphoid tissueQ36307154
Efficacy of retinol palmitate eye drops for dry eye in rabbits with lacrimal gland resectionQ36308741
Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndromeQ36318183
Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activityQ36423494
The dominant human conjunctival epithelial CD8αβ+ T cell population is maintained with age but the number of CD4+ T cells increasesQ36483107
Antigen-specific CD4(+) regulatory T cells in the intestineQ36570475
Innate immunity in the mucosal immune systemQ36651939
Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune systemQ36673995
IL-17 disrupts corneal barrier following desiccating stress.Q36676135
Ocular surface parameters in older male veteransQ36683576
Dendritic cells in human agingQ36689442
Corneal antigen-presenting cellsQ36722795
Dry eye syndromesQ36722830
Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesisQ36758312
Inflammation in dry age-related macular degenerationQ36794192
Role of host-defence peptides in eye diseasesQ36799596
Dry eye disease and microbial keratitis: is there a connection?Q36799601
Dry eye disease: an immune-mediated ocular surface disorderQ36916372
The CCR6/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye diseaseQ36926074
P433issue3
P921main subjecteye diseaseQ3041498
mucosal immune systemQ6931261
P304page(s)327-347
P577publication date2014-12-01
P1433published inOcular Immunology and InflammationQ15760486
P1476titleAge-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease
P478volume24

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Q49487998The improvement of dry eye after cataract surgery by intraoperative using ophthalmic viscosurgical devices on the surface of cornea: The results of a consort-compliant randomized controlled trial.cites workP2860

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