Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila.

scientific article published on 28 December 2011

Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2011.12.044
P932PMC publication ID3288177
P698PubMed publication ID22226837
P5875ResearchGate publication ID221730747

P50authorSanford BernsteinQ42880156
P2093author name stringAnju Melkani
Girish C Melkani
William A Kronert
P2860cites workAlternative relay domains of Drosophila melanogaster myosin differentially affect ATPase activity, in vitro motility, myofibril structure and muscle functionQ36861134
Alternative versions of the myosin relay domain differentially respond to load to influence Drosophila muscle kineticsQ36981755
Vectors for P-mediated transformation in DrosophilaQ39303518
Mutations in the relay loop region result in dominant-negative inhibition of myosin II function in DictyosteliumQ40398998
Ultrastructural and molecular analyses of homozygous-viable Drosophila melanogaster muscle mutants indicate there is a complex pattern of myosin heavy-chain isoform distributionQ41832980
Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.Q41929173
Analysis of Drosophila paramyosin: identification of a novel isoform which is restricted to a subset of adult musclesQ42126012
The myosin relay helix to converter interface remains intact throughout the actomyosin ATPase cycleQ43559880
The myosin converter domain modulates muscle performanceQ43922164
Dictyostelium myosin II mutations that uncouple the converter swing and ATP hydrolysis cycleQ44270903
Variable N-terminal regions of muscle myosin heavy chain modulate ATPase rate and actin sliding velocityQ44329034
Requirement of domain-domain interaction for conformational change and functional ATP hydrolysis in myosinQ44447210
Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical couplingQ44594103
Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speedQ45267700
An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kineticsQ46696477
The mechanism of the reverse recovery step, phosphate release, and actin activation of Dictyostelium myosin II.Q46796814
Site directed mutagenesis of Drosophila flightin disrupts phosphorylation and impairs flight muscle structure and mechanicsQ46969681
Defects in the Drosophila myosin rod permit sarcomere assembly but cause flight muscle degenerationQ48073563
Drosophila muscle myosin heavy chain encoded by a single gene in a cluster of muscle mutationsQ48399570
Insights into the chemomechanical coupling of the myosin motor from simulation of its ATP hydrolysis mechanism.Q51630522
Characterisation of missense mutations in the Act88F gene of Drosophila melanogasterQ52446671
Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts.Q52519868
Impairment of muscle function caused by mutations of phosphorylation sites in myosin regulatory light chain.Q52538689
Fine tuning a molecular motor: the location of alternative domains in the Drosophila myosin head.Q52558743
Functional Characterisation of Dictyostelium Myosin II with Conserved Tryptophanyl Residue 501 Mutated to TyrosineQ58491131
Tryptophan 512 is sensitive to conformational changes in the rigid relay loop of smooth muscle myosin during the MgATPase cycleQ73825754
Isolating and localizing ATP-sensitive tryptophan emission in skeletal myosin subfragment 1Q74337269
The principal motions involved in the coupling mechanism of the recovery stroke of the myosin motorQ79714990
Simulations of the myosin II motor reveal a nucleotide-state sensing element that controls the recovery strokeQ79961224
The structural coupling between ATPase activation and recovery stroke in the myosin II motorQ80631486
Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke stateQ27765344
Genetic Transformation of Drosophila with Transposable Element VectorsQ29618208
Kinetics of structural changes in the relay loop and SH3 domain of myosinQ30160305
Functional domains of the Drosophila melanogaster muscle myosin heavy-chain gene are encoded by alternatively spliced exonsQ30450397
Myosin functional domains encoded by alternative exons are expressed in specific thoracic muscles of DrosophilaQ30451591
Structural mechanism of the recovery stroke in the myosin molecular motorQ30475847
Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac musclesQ30481206
Alternative exon-encoded regions of Drosophila myosin heavy chain modulate ATPase rates and actin sliding velocity.Q31778397
Spatially and temporally regulated expression of myosin heavy chain alternative exons during Drosophila embryogenesis.Q32079160
The converter domain modulates kinetic properties of Drosophila myosinQ33185427
The structural basis of muscle contractionQ33932430
Mutating the converter-relay interface of Drosophila myosin perturbs ATPase activity, actin motility, myofibril stability and flight abilityQ33987018
Mutation of the myosin converter domain alters cross-bridge elasticityQ34019053
The influence of myosin converter and relay domains on cross-bridge kinetics of Drosophila indirect flight muscleQ34099091
Suppression of muscle hypercontraction by mutations in the myosin heavy chain gene of Drosophila melanogaster.Q34617529
Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin headQ35059426
Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinitiesQ35150221
Disrupting the myosin converter-relay interface impairs Drosophila indirect flight muscle performanceQ35187530
Myosin heavy chain isoforms regulate muscle function but not myofibril assemblyQ35907333
Molecular and ultrastructural defects in a Drosophila myosin heavy chain mutant: differential effects on muscle function produced by similar thick filament abnormalitiesQ36221171
Predicting allosteric communication in myosin via a pathway of conserved residuesQ36247779
A tropomyosin-2 mutation suppresses a troponin I myopathy in DrosophilaQ36285684
Characterization of a hypercontraction-induced myopathy in Drosophila caused by mutations in Mhc.Q36321914
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
P304page(s)543-557
P577publication date2011-12-28
P1433published inJournal of Molecular BiologyQ925779
P1476titleAlternative relay and converter domains tune native muscle myosin isoform function in Drosophila
P478volume416

Reverse relations

cites work (P2860)
Q36444036A Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION.
Q51627904Alternative exon-encoding regions of Locusta migratoria muscle myosin modulate the pH dependence of ATPase activity.
Q30838224Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy
Q58695874Molecular parallelism in fast-twitch muscle proteins in echolocating mammals
Q41909842Shared gene structures and clusters of mutually exclusive spliced exons within the metazoan muscle myosin heavy chain genes
Q37629911To understand muscle you must take it apart
Q33693614Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals

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