Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death

scientific article published on 19 September 2015

Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BCP.2015.09.004
P932PMC publication ID4610366
P698PubMed publication ID26394026

P50authorConcetta DiRussoQ25324859
Paul N. BlackQ56155401
Craig W. LindsleyQ67215429
Constance AhowessoQ117207104
David MontefuscoQ117207105
P2093author name stringShaun R Stauffer
Nipun Saini
Chrysa Malosh
Jessica Chekal
P2860cites workHuman very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport proteinQ22010504
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Targeted deletion of fatty acid transport protein-4 results in early embryonic lethalityQ28511574
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CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related to cell lipid and insulin responsivenessQ28578805
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscleQ28586493
Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissueQ28587877
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Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesityQ28594092
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Expression cloning and characterization of a novel adipocyte long chain fatty acid transport proteinQ34325172
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Triglyceride accumulation protects against fatty acid-induced lipotoxicityQ34866329
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Cardiac lipotoxicity: molecular pathways and therapeutic implicationsQ36824112
Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB.Q36846424
Initiation and execution of lipotoxic ER stress in pancreatic beta-cellsQ36910693
Lipotoxic heart disease in obese rats: implications for human obesityQ37117677
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Saturated with fat: new perspectives on lipotoxicityQ37388367
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver diseaseQ37405640
Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equalQ37578517
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytesQ37625425
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicityQ37707665
Oxidative stress and lipid peroxidation by-products at the crossroad between adipose organ dysregulation and obesity-linked insulin resistanceQ38070281
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Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosisQ39731721
Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cellsQ39764118
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Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytesQ39885259
Design, synthesis, and characterization of new iron chelators with anti-proliferative activity: structure-activity relationships of novel thiohydrazone analogues.Q40061650
Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4.Q40286683
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycleQ40334538
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.Q40452210
Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cells.Q40752284
Chronic effects of different fatty acids and leptin in INS-1 cellsQ40834794
Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolismQ42462866
Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.Q42712305
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Fatty acid transport and activation and the expression patterns of genes involved in fatty acid traffickingQ42810966
CD36 as a target to prevent cardiac lipotoxicity and insulin resistanceQ43500625
Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spilloverQ43555581
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Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesityQ64377000
Effect of the lipase inhibitor orlistat and of dietary lipid on the absorption of radiolabelled triolein, tri-γ-linolenin and tripalmitin in miceQ71951883
Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of LangerhansQ72223826
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Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitorsQ84504455
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
cell deathQ2383867
P304page(s)167-181
P577publication date2015-09-19
P1433published inBiochemical PharmacologyQ864229
P1476titleChemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death
P478volume98

Reverse relations

cites work (P2860)
Q89107815Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins
Q90437105Deletion of Fatty Acid Transport Protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes
Q50420689Developmental origins of non-alcoholic fatty liver disease as a risk factor for exaggerated metabolic and cardiovascular-renal disease.
Q37102291Fatty Acid Transport Proteins: Targeting FATP2 as a Gatekeeper Involved in the Transport of Exogenous Fatty Acids
Q93163644Fatty acid transport protein 2 reprograms neutrophils in cancer
Q60044667Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease
Q57297096Intestinal Saturated Long-Chain Fatty Acid, Glucose and Fructose Transporters and Their Inhibition by Natural Plant Extracts in Caco-2 Cells
Q102220205Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis
Q92502767Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis
Q58548697Rosiglitazone ameliorates palmitic acid-induced cytotoxicity in TM4 Sertoli cells
Q42374211Sodium fluorocitrate having protective effect on palmitate-induced beta cell death improves hyperglycemia in diabetic db/db mice

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